3-IODO-L-TYROSINE

Product Name: 3-IODO-L-TYROSINE
CAS No.: 70-78-0
Chemical Name: 3-IODO-L-TYROSINE
Synonyms: H-Tyr;NSC210787;3-I-L-Tyr-OH;H-3-I-TYR-OH;Iodotyrosine;H-TYR(M-I)-OH;H-TYR(3-I)-OH;3-Iodo-Tyr-OH;3-IODO-TYROSINE;H-L-TYR(3-I)-OH
CBNumber: CB5721061
Molecular Formula: C9H10INO3
Formula Weight: 307.09
MOL File: 70-78-0.mol

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3-IODO-L-TYROSINE Property

Melting point:: 210 °C (dec.)(lit.)
Density: 1.7280 (estimate)
storage temp.: -20°C
solubility: dilute aqueous acid: soluble
form: Solid
Boiling point:: 391.0±42.0 °C(Predicted)
pka: 2.21±0.20(Predicted)
color: White to off-white
Sensitive: Light Sensitive
Merck: 14,5047
BRN: 2941266
Stability:: Hygroscopic
InChIKey: UQTZMGFTRHFAAM-ZETCQYMHSA-N
CAS DataBase Reference: 70-78-0(CAS DataBase Reference)
EPA Substance Registry System: L-Tyrosine, 3-iodo- (70-78-0)

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Safety

Safety Statements: 24/25
WGK Germany: 3
F: 8-10-23
HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I8250
Product name: 3-Iodo-L-tyrosine
Packaging: 1g
Price: $68.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: I8250
Product name: 3-Iodo-L-tyrosine
Packaging: 5g
Price: $249
Updated: 2024/03/01

TCI Chemical

Product number: I0075
Product name: 3-Iodo-L-tyrosine
Purity: >98.0%(T)
Packaging: 1g
Price: $83
Updated: 2024/03/01

TCI Chemical

Product number: I0075
Product name: 3-Iodo-L-tyrosine
Purity: >98.0%(T)
Packaging: 5g
Price: $329
Updated: 2024/03/01

Alfa Aesar

Product number: H63789
Product name: 3-Iodo-L-tyrosine, 98%
Packaging: 1g
Price: $33.65
Updated: 2024/03/01

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3-IODO-L-TYROSINE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A novel flavoprotein responsible for iodide salvage in thyroid glands. A tyrosine hydroxylase inhibitor.

Uses

3-iodo-l-tyrosine is used in the inhibition of tyrosine hydroxylase. 3-iodo-L-tyrosine is used in the rapid induction of prolactin secretion.

Uses

3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.

Definition

ChEBI: The monoiodotyrosine that is L-tyrosine carrying an iodo-substituent at position C-3 of the benzyl group.

General Description

Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3).

Biochem/physiol Actions

3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.

Purification Methods

Likely impurities are tyrosine, diiodotyrosine and iodide. Crystallise it by dissolving it in concentrated ammonia (~200mg in ~20mL), evaporate to ~5mL and NH4Cl is added to pH4.5—5.0. After a few hours at 0o, the amino acid crystallises in needles. It is filtered off, washed with a little ice-cold H2O and dried in a vacuum. Alternatively dissolve it in dilute ammonia at room temperature, then add dilute acetic acid to pH 6. Store it at 0o. Recrystallisation of ~250mg from H2O (~5mL) removes any diiodotyrosine. It is an inhibitor of tyrosine hydroxylase with a Ki of ~500nM. [Harrington & Rivers Biochem J 38 320 1944, Rivers Chem & Ind (London) 21 1956, Beilstein 14 III 1562, 14 IV 1562.]

3-IODO-L-TYROSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-IODO-L-TYROSINE Suppliers

Americas 1 Belgium 1 Canada 1 China 184 Europe 3 France 1 Germany 4 India 6 Japan 4 Switzerland 3 United Kingdom 9 United States 32 USA 1 Global 250

Shifang ShengYuan Technology Co., Ltd.

Tel: 0838-6510595 13402890778 18881099744
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Wuxi maimo topp biotechnology co., LTD

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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future industrial shanghai co., ltd

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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GL Biochem (Shanghai) Ltd

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View Lastest Price from 3-IODO-L-TYROSINE manufacturers

Suzhou Ryan Pharmachem Technology Co.,Ltd.

Product: 3-iodo-L -tyrosine 70-78-0
Price: US $0.00-0.00/kg
Min. Order: 5kg
Purity: 98%
Supply Ability: kg grade
Release date: 2023-05-10

Honest Joy Holdings Limited

Product: 3-Iodo-l-tyrosine 70-78-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.5%
Supply Ability: 100 tons
Release date: 2022-02-18

Career Henan Chemical Co

Product: 3-IODO-L-TYROSINE 70-78-0
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 98%
Supply Ability: 1kg,2kg,100kg
Release date: 2019-07-09

70-78-0, 3-IODO-L-TYROSINERelated Search:

REVERSE T3 3,5-Diiodo-L-thyronine 3,3',5-Triiodo-L-thyronine 3,3',5-TRIIODOTHYROPROPIONIC ACID Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED 3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID N-ForMyl Thyroxine 3,5,3',5'-Tetraiodo Thyroaldehyde 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetaMide 3,5,3',5'-Tetraiodo Thyrolactic Acid 3,3',5-TRIIODOTHYROACETIC ACID O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Liothyronine IMpurity E Levothyroxine impurity E Sodium levothyroxine Levothyroxine sodium N-Acetyl-3,5-diiodo-L-tyrosine

3-Iodo-4-hydroxyphenylalanine

4-Hydroxy-3-iodophenylalanine

(S)-2-AMino-3-(4-hydroxy-3-iodophenyl)propanoic acid

(2S)-2-ammonio-3-(4-hydroxy-3-iodophenyl)propanoate

L-TYROSINE, 3-IODO-

3-I-L-Tyr-OH

3-Iodo-L-tyrosine≥ 98% (HPLC)

H-L-Phe(3-I,4-OH)-OH

3-IODO-TYROSINE

3-IODO-L-TYROSINE

3-MONOIODO-L-TYROSINE

S(-)-3-IODO-4-HYDROXY-PHENYLAMINE

M-IODO-L-TYROSINE

3-iodine-L- tyrosine

H-TYR(M-I)-OH

H-TYR(3-I)-OH

H-L-TYR(3-I)-OH

H-3-IODO-TYR-OH

H-3-I-PHE(4-OH)-OH

H-3-I-TYR-OH

3-Monoiodo-L-tyrosine 3-Iodo-L-tyrosine

Iodotyrosine

(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid

3-IODO-L -TYROSINE 97%

3-Iodo-L-tyrosine,97%

3-Iodo-Tyr-OH

3-Iodo-L-tyrosine,3-Monoiodo-L-tyrosine

3-Iodo-L-tyrosine, 97% 1GR

3-Iodo-L-tyrosine&gt

3-1odo-L-tyrosine

3-IODO-L-TYROSINE USP/EP/BP

Liothyronine Impurity 1

MIT (amino acid)

NSC210787

Tyrosine,3-iodo-, L- (8CI)

Liothyronine Impurity 2

H-Tyr

Metoprolol Impurity 35

70-78-0

IC6H34OHCH2CHNH2CO2H

C9H10INO3

Tyrosine Derivatives

Unnatural Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

amino

Unusual Amino Acids

Amino Acids 13C, 2H, 15N

Amino Acids

Biochemistry

Biological-modified Amino Acids

Amino Acids & Derivatives

Inhibitors

Aromatics

Chiral Reagents