O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine

Product Name: O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
CAS No.: 4604-41-5
Chemical Name: O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
Synonyms: 3,3'-L-Diiodothyronine;L-3,3'-Diiodothyronine;Levothyroxine EP Imp J;3,3'-Diiodo-L-thyronine;Levothyroxine Impurity J;Levothyroxine EP Impurity J;3,5-Diiodo-L-tyrosinedihydrae;3,3’-Diiodo-L-thyronine (>97%);3,3'-Diiodo-L-thyronine - [D72021];O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
CBNumber: CB6930097
Molecular Formula: C15H13I2NO4
Formula Weight: 525.08
MOL File: 4604-41-5.mol

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O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Property

Melting point:: 178-180°C
Boiling point:: 520.7±50.0 °C(Predicted)
Density: 2.095±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Aqueous Base (Slightly)
form: Solid
pka: 2.17±0.20(Predicted)
color: Off-White to Beige
Stability:: Light Sensitive
InChI: InChI=1S/C15H13I2NO4/c16-10-7-9(2-3-13(10)19)22-14-4-1-8(5-11(14)17)6-12(18)15(20)21/h1-5,7,12,19H,6,18H2,(H,20,21)/t12-/m0/s1
InChIKey: CPCJBZABTUOGNM-LBPRGKRZSA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C(OC2=CC=C(O)C(I)=C2)C(I)=C1)N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 719536
Product name: 3,3′-Diiodo-L-thyronine (T2)
Purity: 98% (CP)
Packaging: 1mg
Price: $177.21
Updated: 2025/07/31

Sigma-Aldrich

Product number: 719536
Product name: 3,3′-Diiodo-L-thyronine (T2)
Purity: 98% (CP)
Packaging: 5mg
Price: $892
Updated: 2025/07/31

Cayman Chemical

Product number: 16748
Product name: 3,3'-Diiodo-L-thyronine
Purity: ≥95%
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 16748
Product name: 3,3'-Diiodo-L-thyronine
Purity: ≥95%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Sigma-Aldrich

Product number: 719536
Product name: 3,3′-Diiodo-L-thyronine (T2)
Purity: 98% (CP)
Packaging: 10mg
Price: $1680
Updated: 2025/07/31

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O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Chemical Properties,Usage,Production

Description

3,3''-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3’-T2. It is derived enzymatically from triiodothyronine isoforms T3 and reverse T3. T2 and its analog 3,5-T2 stimulate the activity of cytochrome c oxidase by blocking inhibition by ATP.

Chemical Properties

Off-White Powder

Uses

Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.

Definition

ChEBI: 3,3'-diiodo-L-thyronine is a 3,3'-diiodothyronine. It has a role as a human metabolite.

IC 50

Human Endogenous Metabolite; COX

References

[1] G PINNA. 3,3’-Diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors and of healthy subjects during acute stress.[J]. Journal of Clinical Endocrinology & Metabolism, 1998, 83 9: 3071-3077. DOI: 10.1210/jcem.83.9.5080
[2] F. GOGLIA . Interaction of diiodothyronines with isolated cytochromec oxidase[J]. FEBS Letters, 1994, 346 2: Pages 295-298. DOI: 10.1016/0014-5793(94)00476-5
[3] S ARNOLD B K F Goglia. 3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP.[J]. European journal of biochemistry, 1998, 252 2: 325-330. DOI: 10.1046/j.1432-1327.1998.2520325.x

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Preparation Products And Raw materials

Raw materials

Preparation Products

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O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Suppliers

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View Lastest Price from O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine manufacturers

Career Henan Chemical Co

Product: O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine 4604-41-5
Price: US $3.00/KG
Min. Order: 1KG
Purity: 90%-99.9%
Supply Ability: 500kg
Release date: 2019-07-04

4604-41-5, O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosineRelated Search:

REVERSE T3 3,5-Diiodo-L-thyronine Levothyroxine EP Impurity B 4-(4-Hydroxyphenoxy)-3,5-diiodo-benzaldehyde 3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED Levothyroxine Impurity 16 N-ForMyl Thyroxine 3,5,3',5'-Tetraiodo Thyroaldehyde 3,5-Diiodo-4-(p-Methoxyphenoxy)-benzaldehyde 3-IODO-L-TYROSINE 3,3',5-TRIIODOTHYROACETIC ACID Liothyronine IMpurity E Levothyroxine impurity E 3,3',5-TRIIODOTHYROPROPIONIC ACID Levothyroxine Impurity 14 Levothyroxine Levothyroxine O-Methyl Amine Impurity

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine

3,5-Diiodo-L-tyrosinedihydrae

(S)-α-Amino-4-[(4-hydroxy-3-iodophenyl)oxy]-3-iodobenzenepropanoic acid

3-Iodo-O-(4-hydroxy-3-iodophenyl)-L-tyrosine

O-(3-Iodo-4-hydroxyphenyl)-3-iodo-L-tyrosine

3,3'-Diiodo-L-thyronine

(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid

(2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3-iodo-phenyl]propionic acid

(2S)-2-azanyl-3-[4-(4-hydroxy-3-iodo-phenoxy)-3-iodo-phenyl]propanoic acid

3-[4-(4-Hydroxy-3-iodophenoxy)-3-iodophenyl]-L-alanine

L-Tyrosine,O-(4-hydroxy-3-iodophenyl)-3-iodo-

3,3'-L-Diiodothyronine

Levothyroxine EP Impurity J

L-3,3'-Diiodothyronine

Levothyroxine Impurity 9（Levothyroxine EP Impurity J）

3,3'-L-Diiodothyronine (Levothyroxine Impurity J)

Levothyroxine Impurity J

Levothyroxine EP Imp J

3'-L-Diiodothyronine (Levothyroxine Impurity J)

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine USP/EP/BP

Alanine,3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]-, L- (8CI)

3,3'-Diiodo-L-thyronine (Levothyroxine Impurity)

LEVOTHYROXINE EP IMPURITY J | 3,3-DIIODO-L-THYRONINE

3,3'-Diiodo-L-thyronine - [D72021]

3,3’-Diiodo-L-thyronine (>97%)

4604-41-5

Amino Acids & Derivatives

Labeling and Diagnostics Reagents