ChemicalBook > CAS DataBase List > O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine

Product Name
O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
CAS No.
4604-41-5
Chemical Name
O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
Synonyms
3,3'-L-Diiodothyronine;L-3,3'-Diiodothyronine;Levothyroxine EP Imp J;3,3'-Diiodo-L-thyronine;Levothyroxine Impurity J;Levothyroxine EP Impurity J;3,5-Diiodo-L-tyrosinedihydrae;3,3’-Diiodo-L-thyronine (>97%);3,3'-Diiodo-L-thyronine - [D72021];O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
CBNumber
CB6930097
Molecular Formula
C15H13I2NO4
Formula Weight
525.08
MOL File
4604-41-5.mol
More
Less

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Property

Melting point:
178-180°C
Boiling point:
520.7±50.0 °C(Predicted)
Density 
2.095±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Aqueous Base (Slightly)
form 
Solid
pka
2.17±0.20(Predicted)
color 
Off-White to Beige
Stability:
Light Sensitive
InChI
InChI=1S/C15H13I2NO4/c16-10-7-9(2-3-13(10)19)22-14-4-1-8(5-11(14)17)6-12(18)15(20)21/h1-5,7,12,19H,6,18H2,(H,20,21)/t12-/m0/s1
InChIKey
CPCJBZABTUOGNM-LBPRGKRZSA-N
SMILES
C(O)(=O)[C@H](CC1=CC=C(OC2=CC=C(O)C(I)=C2)C(I)=C1)N
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
719536
Product name
3,3′-Diiodo-L-thyronine (T2)
Purity
98% (CP)
Packaging
1mg
Price
$177.21
Updated
2025/07/31
Sigma-Aldrich
Product number
719536
Product name
3,3′-Diiodo-L-thyronine (T2)
Purity
98% (CP)
Packaging
5mg
Price
$892
Updated
2025/07/31
Cayman Chemical
Product number
16748
Product name
3,3'-Diiodo-L-thyronine
Purity
≥95%
Packaging
500μg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
16748
Product name
3,3'-Diiodo-L-thyronine
Purity
≥95%
Packaging
1mg
Price
$121
Updated
2024/03/01
Sigma-Aldrich
Product number
719536
Product name
3,3′-Diiodo-L-thyronine (T2)
Purity
98% (CP)
Packaging
10mg
Price
$1680
Updated
2025/07/31
More
Less

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Chemical Properties,Usage,Production

Description

3,3''-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3’-T2. It is derived enzymatically from triiodothyronine isoforms T3 and reverse T3. T2 and its analog 3,5-T2 stimulate the activity of cytochrome c oxidase by blocking inhibition by ATP.

Chemical Properties

Off-White Powder

Uses

Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.

Definition

ChEBI: 3,3'-diiodo-L-thyronine is a 3,3'-diiodothyronine. It has a role as a human metabolite.

IC 50

Human Endogenous Metabolite; COX

References

[1] G PINNA. 3,3’-Diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors and of healthy subjects during acute stress.[J]. Journal of Clinical Endocrinology & Metabolism, 1998, 83 9: 3071-3077. DOI: 10.1210/jcem.83.9.5080
[2] F. GOGLIA . Interaction of diiodothyronines with isolated cytochromec oxidase[J]. FEBS Letters, 1994, 346 2: Pages 295-298. DOI: 10.1016/0014-5793(94)00476-5
[3] S ARNOLD  B K  F Goglia. 3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP.[J]. European journal of biochemistry, 1998, 252 2: 325-330. DOI: 10.1046/j.1432-1327.1998.2520325.x

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Suppliers

Canada 1 China 129 Germany 1 India 5 United Kingdom 1 United States 21 Global 158
Suzhou Zehou Biotechnology Co. , Ltd.
Tel
0512-68716880 19984816880
Fax
18075373931
Email
sales@growingchem.com
Country
China
ProdList
212
Advantage
64
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Suzhou Ryan Pharmaceutical Technology Co., Ltd.
Tel
0512-68780025 18962125825
Email
sales@ryanchem.com
Country
China
ProdList
167
Advantage
62
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7471
Advantage
65
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5158
Advantage
50
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
Suzhou Ryan Pharmachem Technology Co.,Ltd
Tel
0512-66585217 13962137180
Fax
0512-82177549
Email
sales@ryanchem.com
Country
China
ProdList
384
Advantage
55
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1955
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shifang ShengYuan Technology Co., Ltd.
Tel
0838-6510595 13402890778 15102836436
Email
1120021438@qq.com
Country
China
ProdList
132
Advantage
56
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
6295
Advantage
60
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-58362220 0086-15250997978
Fax
025-58362220
Email
sale@njxizebio.com
Country
China
ProdList
4855
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Cck Pharmchem Co.,Ltd
Tel
0512-68131995 13862051930
Fax
0512-68131995
Country
China
ProdList
360
Advantage
55
Wuhan HongxinKang Fine Chemical Co., Ltd.
Tel
027-59362599 18674037007
Fax
027-84802889
Email
zhuoxingwc@163.com
Country
China
ProdList
950
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
10063
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
13316949107 13316968096
Email
1979313431@qq.com
Country
China
ProdList
9564
Advantage
58
TOSUN PHARM
Tel
020-61855200 13326451905
Email
260366801@qq.com
Country
China
ProdList
7924
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
sgtlifesciences pvt ltd
Tel
+8617013299288
Email
dj@sgtlifesciences.com
Country
China
ProdList
12373
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Shanxi Xuanran Import and Export Trade Co., Ltd.
Tel
+8617735180244
Email
mike_yan@xuanranglobal.com
Country
CHINA
ProdList
4017
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
sales@afinechem.com
Country
China
ProdList
15109
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
20284
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 19925672674
Fax
QQ 3008233717
Email
3008233746@qq.com
Country
China
ProdList
9883
Advantage
12
SIMAGCHEM CORP
Tel
+86-5922680277 +86-13806087780
Email
sale@simagchem.com
Country
China
ProdList
17346
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23912
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Anqing Runke Biomedical Technology Co., Ltd.
Tel
0512-68716880 19984816880
Fax
0556-5282330
Email
sales@growingchem.com
Country
China
ProdList
307
Advantage
58
Shanghai Jiange Chemical Co., Ltd.
Tel
15921040873
Email
1434142450@qq.com
Country
CHINA
ProdList
7649
Advantage
58
Shochem(Shanghai) Co.,Ltd
Tel
86-21-50800795
Email
info@shochem.com
Country
CHINA
ProdList
288
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Nanjing wangzhixing Pharmaceutical Technology Co., Ltd
Tel
18569809817
Fax
025-85722793
Email
2208093734@qq.com
Country
China
ProdList
3978
Advantage
58
Nanjing shengyilai Chemical Co., Ltd
Tel
19951936396
Email
3158688292@qq.com
Country
China
ProdList
4856
Advantage
58
Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
Email
sales@mitachieve.com
Country
China
ProdList
8860
Advantage
58
More
Less

View Lastest Price from O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine manufacturers

Career Henan Chemical Co
Product
O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine 4604-41-5
Price
US $3.00/KG
Min. Order
1KG
Purity
90%-99.9%
Supply Ability
500kg
Release date
2019-07-04

4604-41-5, O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosineRelated Search:

REVERSE T3 3,5-Diiodo-L-thyronine Levothyroxine EP Impurity B 4-(4-Hydroxyphenoxy)-3,5-diiodo-benzaldehyde 3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED Levothyroxine Impurity 16 N-ForMyl Thyroxine 3,5,3',5'-Tetraiodo Thyroaldehyde 3,5-Diiodo-4-(p-Methoxyphenoxy)-benzaldehyde 3-IODO-L-TYROSINE 3,3',5-TRIIODOTHYROACETIC ACID Liothyronine IMpurity E Levothyroxine impurity E 3,3',5-TRIIODOTHYROPROPIONIC ACID Levothyroxine Impurity 14 Levothyroxine Levothyroxine O-Methyl Amine Impurity

  • O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
  • 3,5-Diiodo-L-tyrosinedihydrae
  • (S)-α-Amino-4-[(4-hydroxy-3-iodophenyl)oxy]-3-iodobenzenepropanoic acid
  • 3-Iodo-O-(4-hydroxy-3-iodophenyl)-L-tyrosine
  • O-(3-Iodo-4-hydroxyphenyl)-3-iodo-L-tyrosine
  • 3,3'-Diiodo-L-thyronine
  • (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid
  • (2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3-iodo-phenyl]propionic acid
  • (2S)-2-azanyl-3-[4-(4-hydroxy-3-iodo-phenoxy)-3-iodo-phenyl]propanoic acid
  • 3-[4-(4-Hydroxy-3-iodophenoxy)-3-iodophenyl]-L-alanine
  • L-Tyrosine,O-(4-hydroxy-3-iodophenyl)-3-iodo-
  • 3,3'-L-Diiodothyronine
  • Levothyroxine EP Impurity J
  • L-3,3'-Diiodothyronine
  • Levothyroxine Impurity 9（Levothyroxine EP Impurity J）
  • 3,3'-L-Diiodothyronine (Levothyroxine Impurity J)
  • Levothyroxine Impurity J
  • Levothyroxine EP Imp J
  • 3'-L-Diiodothyronine (Levothyroxine Impurity J)
  • O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine USP/EP/BP
  • Alanine,3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]-, L- (8CI)
  • 3,3'-Diiodo-L-thyronine (Levothyroxine Impurity)
  • LEVOTHYROXINE EP IMPURITY J | 3,3-DIIODO-L-THYRONINE
  • 3,3'-Diiodo-L-thyronine - [D72021]
  • 3,3’-Diiodo-L-thyronine (>97%)
  • 4604-41-5
  • Amino Acids & Derivatives
  • Labeling and Diagnostics Reagents