3-IODO-L-TYROSINE
- Product Name
- 3-IODO-L-TYROSINE
- CAS No.
- 70-78-0
- Chemical Name
- 3-IODO-L-TYROSINE
- Synonyms
- H-Tyr;NSC210787;3-I-L-Tyr-OH;H-3-I-TYR-OH;Iodotyrosine;H-TYR(M-I)-OH;H-TYR(3-I)-OH;3-Iodo-Tyr-OH;3-IODO-TYROSINE;H-L-TYR(3-I)-OH
- CBNumber
- CB5721061
- Molecular Formula
- C9H10INO3
- Formula Weight
- 307.09
- MOL File
- 70-78-0.mol
3-IODO-L-TYROSINE Property
- Melting point:
- 210 °C (dec.)(lit.)
- Density
- 1.7280 (estimate)
- storage temp.
- -20°C
- solubility
- dilute aqueous acid: soluble
- form
- Solid
- Boiling point:
- 391.0±42.0 °C(Predicted)
- pka
- 2.21±0.20(Predicted)
- color
- White to off-white
- Sensitive
- Light Sensitive
- Merck
- 14,5047
- BRN
- 2941266
- Stability:
- Hygroscopic
- InChIKey
- UQTZMGFTRHFAAM-ZETCQYMHSA-N
- CAS DataBase Reference
- 70-78-0(CAS DataBase Reference)
- EPA Substance Registry System
- L-Tyrosine, 3-iodo- (70-78-0)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- I8250
- Product name
- 3-Iodo-L-tyrosine
- Packaging
- 1g
- Price
- $68.4
- Updated
- 2024/03/01
- Product number
- I8250
- Product name
- 3-Iodo-L-tyrosine
- Packaging
- 5g
- Price
- $249
- Updated
- 2024/03/01
- Product number
- I0075
- Product name
- 3-Iodo-L-tyrosine
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $83
- Updated
- 2024/03/01
- Product number
- I0075
- Product name
- 3-Iodo-L-tyrosine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $329
- Updated
- 2024/03/01
- Product number
- H63789
- Product name
- 3-Iodo-L-tyrosine, 98%
- Packaging
- 1g
- Price
- $33.65
- Updated
- 2024/03/01
3-IODO-L-TYROSINE Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
A novel flavoprotein responsible for iodide salvage in thyroid glands. A tyrosine hydroxylase inhibitor.
Uses
3-iodo-l-tyrosine is used in the inhibition of tyrosine hydroxylase. 3-iodo-L-tyrosine is used in the rapid induction of prolactin secretion.
Uses
3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.
Definition
ChEBI: The monoiodotyrosine that is L-tyrosine carrying an iodo-substituent at position C-3 of the benzyl group.
General Description
Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3).
Biochem/physiol Actions
3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.
Purification Methods
Likely impurities are tyrosine, diiodotyrosine and iodide. Crystallise it by dissolving it in concentrated ammonia (~200mg in ~20mL), evaporate to ~5mL and NH4Cl is added to pH4.5—5.0. After a few hours at 0o, the amino acid crystallises in needles. It is filtered off, washed with a little ice-cold H2O and dried in a vacuum. Alternatively dissolve it in dilute ammonia at room temperature, then add dilute acetic acid to pH 6. Store it at 0o. Recrystallisation of ~250mg from H2O (~5mL) removes any diiodotyrosine. It is an inhibitor of tyrosine hydroxylase with a Ki of ~500nM. [Harrington & Rivers Biochem J 38 320 1944, Rivers Chem & Ind (London) 21 1956, Beilstein 14 III 1562, 14 IV 1562.]
3-IODO-L-TYROSINE Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-IODO-L-TYROSINE manufacturers
- Product
- 3-iodo-L -tyrosine 70-78-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 5kg
- Purity
- 98%
- Supply Ability
- kg grade
- Release date
- 2023-05-10
- Product
- 3-Iodo-l-tyrosine 70-78-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 3-IODO-L-TYROSINE 70-78-0
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 98%
- Supply Ability
- 1kg,2kg,100kg
- Release date
- 2019-07-09