ChemicalBook > CAS DataBase List > 3-IODO-L-TYROSINE

3-IODO-L-TYROSINE

Product Name
3-IODO-L-TYROSINE
CAS No.
70-78-0
Chemical Name
3-IODO-L-TYROSINE
Synonyms
H-Tyr;NSC210787;3-I-L-Tyr-OH;H-3-I-TYR-OH;Iodotyrosine;H-TYR(M-I)-OH;H-TYR(3-I)-OH;3-Iodo-Tyr-OH;3-IODO-TYROSINE;H-L-TYR(3-I)-OH
CBNumber
CB5721061
Molecular Formula
C9H10INO3
Formula Weight
307.09
MOL File
70-78-0.mol
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3-IODO-L-TYROSINE Property

Melting point:
210 °C (dec.)(lit.)
Density 
1.7280 (estimate)
storage temp. 
-20°C
solubility 
dilute aqueous acid: soluble
form 
Solid
Boiling point:
391.0±42.0 °C(Predicted)
pka
2.21±0.20(Predicted)
color 
White to off-white
Sensitive 
Light Sensitive
Merck 
14,5047
BRN 
2941266
Stability:
Hygroscopic
InChIKey
UQTZMGFTRHFAAM-ZETCQYMHSA-N
CAS DataBase Reference
70-78-0(CAS DataBase Reference)
EPA Substance Registry System
L-Tyrosine, 3-iodo- (70-78-0)
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Safety

Safety Statements 
24/25
WGK Germany 
3
F 
8-10-23
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I8250
Product name
3-Iodo-L-tyrosine
Packaging
1g
Price
$68.4
Updated
2024/03/01
Sigma-Aldrich
Product number
I8250
Product name
3-Iodo-L-tyrosine
Packaging
5g
Price
$249
Updated
2024/03/01
TCI Chemical
Product number
I0075
Product name
3-Iodo-L-tyrosine
Purity
>98.0%(T)
Packaging
1g
Price
$83
Updated
2024/03/01
TCI Chemical
Product number
I0075
Product name
3-Iodo-L-tyrosine
Purity
>98.0%(T)
Packaging
5g
Price
$329
Updated
2024/03/01
Alfa Aesar
Product number
H63789
Product name
3-Iodo-L-tyrosine, 98%
Packaging
1g
Price
$33.65
Updated
2024/03/01
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3-IODO-L-TYROSINE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A novel flavoprotein responsible for iodide salvage in thyroid glands. A tyrosine hydroxylase inhibitor.

Uses

3-iodo-l-tyrosine is used in the inhibition of tyrosine hydroxylase. 3-iodo-L-tyrosine is used in the rapid induction of prolactin secretion.

Uses

3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.

Definition

ChEBI: The monoiodotyrosine that is L-tyrosine carrying an iodo-substituent at position C-3 of the benzyl group.

General Description

Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3).

Biochem/physiol Actions

3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.

Purification Methods

Likely impurities are tyrosine, diiodotyrosine and iodide. Crystallise it by dissolving it in concentrated ammonia (~200mg in ~20mL), evaporate to ~5mL and NH4Cl is added to pH4.5—5.0. After a few hours at 0o, the amino acid crystallises in needles. It is filtered off, washed with a little ice-cold H2O and dried in a vacuum. Alternatively dissolve it in dilute ammonia at room temperature, then add dilute acetic acid to pH 6. Store it at 0o. Recrystallisation of ~250mg from H2O (~5mL) removes any diiodotyrosine. It is an inhibitor of tyrosine hydroxylase with a Ki of ~500nM. [Harrington & Rivers Biochem J 38 320 1944, Rivers Chem & Ind (London) 21 1956, Beilstein 14 III 1562, 14 IV 1562.]

3-IODO-L-TYROSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-IODO-L-TYROSINE Suppliers

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View Lastest Price from 3-IODO-L-TYROSINE manufacturers

Suzhou Ryan Pharmachem Technology Co.,Ltd.
Product
3-iodo-L -tyrosine 70-78-0
Price
US $0.00-0.00/kg
Min. Order
5kg
Purity
98%
Supply Ability
kg grade
Release date
2023-05-10
Honest Joy Holdings Limited
Product
3-Iodo-l-tyrosine 70-78-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98.5%
Supply Ability
100 tons
Release date
2022-02-18
Career Henan Chemical Co
Product
3-IODO-L-TYROSINE 70-78-0
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
98%
Supply Ability
1kg,2kg,100kg
Release date
2019-07-09

70-78-0, 3-IODO-L-TYROSINERelated Search:

REVERSE T3 3,5-Diiodo-L-thyronine 3,3',5-Triiodo-L-thyronine 3,3',5-TRIIODOTHYROPROPIONIC ACID Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED 3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID N-ForMyl Thyroxine 3,5,3',5'-Tetraiodo Thyroaldehyde 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetaMide 3,5,3',5'-Tetraiodo Thyrolactic Acid 3,3',5-TRIIODOTHYROACETIC ACID O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Liothyronine IMpurity E Levothyroxine impurity E Sodium levothyroxine Levothyroxine sodium N-Acetyl-3,5-diiodo-L-tyrosine

  • 3-Iodo-4-hydroxyphenylalanine
  • 4-Hydroxy-3-iodophenylalanine
  • (S)-2-AMino-3-(4-hydroxy-3-iodophenyl)propanoic acid
  • (2S)-2-ammonio-3-(4-hydroxy-3-iodophenyl)propanoate
  • L-TYROSINE, 3-IODO-
  • 3-I-L-Tyr-OH
  • 3-Iodo-L-tyrosine≥ 98% (HPLC)
  • H-L-Phe(3-I,4-OH)-OH
  • 3-IODO-TYROSINE
  • 3-IODO-L-TYROSINE
  • 3-MONOIODO-L-TYROSINE
  • S(-)-3-IODO-4-HYDROXY-PHENYLAMINE
  • M-IODO-L-TYROSINE
  • 3-iodine-L- tyrosine
  • H-TYR(M-I)-OH
  • H-TYR(3-I)-OH
  • H-L-TYR(3-I)-OH
  • H-3-IODO-TYR-OH
  • H-3-I-PHE(4-OH)-OH
  • H-3-I-TYR-OH
  • 3-Monoiodo-L-tyrosine 3-Iodo-L-tyrosine
  • Iodotyrosine
  • (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid
  • 3-IODO-L -TYROSINE 97%
  • 3-Iodo-L-tyrosine,97%
  • 3-Iodo-Tyr-OH
  • 3-Iodo-L-tyrosine,3-Monoiodo-L-tyrosine
  • 3-Iodo-L-tyrosine, 97% 1GR
  • 3-Iodo-L-tyrosine&gt
  • 3-1odo-L-tyrosine
  • 3-IODO-L-TYROSINE USP/EP/BP
  • Liothyronine Impurity 1
  • MIT (amino acid)
  • NSC210787
  • Tyrosine,3-iodo-, L- (8CI)
  • Liothyronine Impurity 2
  • H-Tyr
  • Metoprolol Impurity 35
  • 70-78-0
  • IC6H34OHCH2CHNH2CO2H
  • C9H10INO3
  • Tyrosine Derivatives
  • Unnatural Amino Acid Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • amino
  • Unusual Amino Acids
  • Amino Acids 13C, 2H, 15N
  • Amino Acids
  • Biochemistry
  • Biological-modified Amino Acids
  • Amino Acids & Derivatives
  • Inhibitors
  • Aromatics
  • Chiral Reagents