ChemicalBook > CAS DataBase List > T0901317

T0901317

Product Name
T0901317
CAS No.
293754-55-9
Chemical Name
T0901317
Synonyms
CS-721;T 1317;T0901317;TO091317;TO-91317;TO-901317;TO 091317;TO-091317;T0901317 (T-1317);T0901317 293754-55-9
CBNumber
CB0368768
Molecular Formula
C17H12F9NO3S
Formula Weight
481.33
MOL File
293754-55-9.mol
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T0901317 Property

Melting point:
116-118°C
Boiling point:
470.5±55.0 °C(Predicted)
Density 
1.550±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Light beige solid
pka
9.00±0.15(Predicted)
color 
Off-White
InChIKey
SGIWFELWJPNFDH-UHFFFAOYSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T2320
Product name
T0901317
Purity
≥98%
Packaging
5mg
Price
$88.4
Updated
2024/03/01
Sigma-Aldrich
Product number
T2320
Product name
T0901317
Purity
≥98%
Packaging
10MG
Price
$140
Updated
2024/03/01
Sigma-Aldrich
Product number
575310
Product name
T0901317
Packaging
10mg
Price
$182
Updated
2024/03/01
Cayman Chemical
Product number
71810
Product name
T0901317
Purity
≥98%
Packaging
10mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
71810
Product name
T0901317
Purity
≥98%
Packaging
50mg
Price
$119
Updated
2024/03/01
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T0901317 Chemical Properties,Usage,Production

Uses

The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.

Uses

T0901317 is a potent and selective agonist for both liver x receptor (LXR) and farnesoid X receptor (FXR).

General Description

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.

Biological Activity

Potent, high affinity liver X receptor (LXR) agonist (EC 50 ~ 50 nM, Kd values are 7 and 22 nM for LXR- α and LRXR- β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid- β production in primary neurons in vitro . Displays an EC 50 of ~ 5 μ M for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

References

[1]. schultz j r, tu h, luk a, et al. role of lxrs in control of lipogenesis[j]. genes & development, 2000, 14(22): 2831-2838.
[2]. kumar n, solt l a, conkright j j, et al. the benzenesulfoamide t0901317 [n-(2, 2, 2-trifluoroethyl)-n-[4-[2, 2, 2-trifluoro-1-hydroxy-1-(trifluoromethyl) ethyl] phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-α/γ inverse agonist[j]. molecular pharmacology, 2010, 77(2): 228-236.
[3]. houck k a, borchert k m, hepler c d, et al. t0901317 is a dual lxr/fxr agonist[j]. molecular genetics and metabolism, 2004, 83(1): 184-187.
[4]. liu y, yan c, wang y, et al. liver x receptor agonist t0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice[j]. endocrinology, 2006, 147(11): 5061-5068.

T0901317 Preparation Products And Raw materials

Raw materials

Preparation Products

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T0901317 Suppliers

Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
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58
Shanghai Hekang Biotechnology Co., Ltd.
Tel
18939837085
Fax
2880152141(QQ)
Email
youchemicals@gmail.com
Country
China
ProdList
1830
Advantage
55
ShangHai KenEn Chemical Technology Co., Ltd.
Tel
13120367189
Fax
021-50315529
Email
mychess007@163.com
Country
China
ProdList
1994
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11578
Advantage
59
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View Lastest Price from T0901317 manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
T0901317 293754-55-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-28

293754-55-9, T0901317Related Search:


  • N-(2,2,2-TRIFLUOROETHYL)-N-[4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL]BENZENESULFONAMIDE
  • T0901317
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  • BenzenesulfonaMide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoroMethyl)ethyl]phenyl]-
  • T 1317
  • T0901317;T 0901317; T-0901317
  • N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]
  • T0901317 - CAS 293754-55-9 - Calbiochem
  • CS-721
  • T0901317 (T-1317)
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  • N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide
  • T0901317 293754-55-9
  • N-(2,2,2-Trifluoroethyl)-N-4-2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethylphenylbenzenesulfonamide
  • TO 091317
  • TO091317
  • TO-091317
  • TO-91317
  • 293754-55-9
  • C17H12NSO3F9
  • C17H12F9NO3S
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • PPAR and RXR Regulators
  • Gene Regulation and Expression
  • PPAR and RXR Regulators
  • Cell Signaling and Neuroscience
  • Gene Regulation and Expression
  • Inhibitors