T0901317

ChemicalBook > CAS DataBase List > T0901317

Product Name: T0901317
CAS No.: 293754-55-9
Chemical Name: T0901317
Synonyms: CS-721;T 1317;T0901317;TO091317;TO-91317;TO-901317;TO 091317;TO-091317;T0901317 (T-1317);T0901317 293754-55-9
CBNumber: CB0368768
Molecular Formula: C17H12F9NO3S
Formula Weight: 481.33
MOL File: 293754-55-9.mol

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T0901317 Property

Melting point:: 116-118°C
Boiling point:: 470.5±55.0 °C(Predicted)
Density: 1.550±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Light beige solid
pka: 9.00±0.15(Predicted)
color: Off-White
InChIKey: SGIWFELWJPNFDH-UHFFFAOYSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T2320
Product name: T0901317
Purity: ≥98%
Packaging: 5mg
Price: $88.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: T2320
Product name: T0901317
Purity: ≥98%
Packaging: 10MG
Price: $140
Updated: 2024/03/01

Sigma-Aldrich

Product number: 575310
Product name: T0901317
Packaging: 10mg
Price: $182
Updated: 2024/03/01

Cayman Chemical

Product number: 71810
Product name: T0901317
Purity: ≥98%
Packaging: 10mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 71810
Product name: T0901317
Purity: ≥98%
Packaging: 50mg
Price: $119
Updated: 2024/03/01

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T0901317 Chemical Properties,Usage,Production

Uses

The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.

Uses

T0901317 is a potent and selective agonist for both liver x receptor (LXR) and farnesoid X receptor (FXR).

General Description

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.

Biological Activity

Potent, high affinity liver X receptor (LXR) agonist (EC 50 ~ 50 nM, Kd values are 7 and 22 nM for LXR- α and LRXR- β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid- β production in primary neurons in vitro . Displays an EC 50 of ~ 5 μ M for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

References

[1]. schultz j r, tu h, luk a, et al. role of lxrs in control of lipogenesis[j]. genes & development, 2000, 14(22): 2831-2838.
[2]. kumar n, solt l a, conkright j j, et al. the benzenesulfoamide t0901317 [n-(2, 2, 2-trifluoroethyl)-n-[4-[2, 2, 2-trifluoro-1-hydroxy-1-(trifluoromethyl) ethyl] phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-α/γ inverse agonist[j]. molecular pharmacology, 2010, 77(2): 228-236.
[3]. houck k a, borchert k m, hepler c d, et al. t0901317 is a dual lxr/fxr agonist[j]. molecular genetics and metabolism, 2004, 83(1): 184-187.
[4]. liu y, yan c, wang y, et al. liver x receptor agonist t0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice[j]. endocrinology, 2006, 147(11): 5061-5068.

T0901317 Preparation Products And Raw materials

Raw materials

Preparation Products

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T0901317 Suppliers

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View Lastest Price from T0901317 manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: T0901317 293754-55-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-28

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N-(2,2,2-TRIFLUOROETHYL)-N-[4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL]BENZENESULFONAMIDE

T0901317

TO-901317

BenzenesulfonaMide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoroMethyl)ethyl]phenyl]-

T 1317

T0901317;T 0901317; T-0901317

N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]

T0901317 - CAS 293754-55-9 - Calbiochem

CS-721

T0901317 (T-1317)

N-(2,2,2-trifluoroethyl)

N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide

T0901317 293754-55-9

N-(2,2,2-Trifluoroethyl)-N-4-2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethylphenylbenzenesulfonamide

TO 091317

TO091317

TO-091317

TO-91317

293754-55-9

C17H12NSO3F9

C17H12F9NO3S

Cell Signaling and Neuroscience

Cell Biology

BioChemical

PPAR and RXR Regulators

Gene Regulation and Expression

PPAR and RXR Regulators

Cell Signaling and Neuroscience

Gene Regulation and Expression

Inhibitors