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24(S),25-Epoxycholesterol (not deuterated)

Product Name
24(S),25-Epoxycholesterol (not deuterated)
CAS No.
77058-74-3
Chemical Name
24(S),25-Epoxycholesterol (not deuterated)
Synonyms
24(S);24S,25-EpoxyC;25-epoxycholesterol;(24S)-24,25-Epoxycholestero;(24S)-24,25-Epoxycholesterol;5-CHOLESTEN-24(S), 25-EPOXY-3β-OL;(24S)-24,25-Epoxycholest-5-en-3β-ol;Cholest-5-en-3-ol, 24,25-epoxy-, (3β,24S)-;Cholest-5-en-3-ol, 24,25-epoxy-, (3β,24S)-;24(S),25-Epoxycholesterol (not deuterated)
CBNumber
CB11121024
Molecular Formula
C27H44O2
Formula Weight
400.64
MOL File
77058-74-3.mol
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24(S),25-Epoxycholesterol (not deuterated) Property

Melting point:
156-157 °C
Boiling point:
496.4±18.0 °C(predicted)
Density 
1.05
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 30 mg/ml).
pka
15.03±0.70(predicted)
form 
White solid.
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10131
Product name
24(S),25-epoxy Cholesterol
Packaging
1mg
Price
$202
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
LIP0002748
Product name
(24S)-24,25-EPOXYCHOLESTEROL
Purity
95.00%
Packaging
5MG
Price
$502.54
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
222
Product name
24(S),25-Epoxycholesterol
Purity
98%
Packaging
1mg
Price
$890
Updated
2021/12/16
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24(S),25-Epoxycholesterol (not deuterated) Chemical Properties,Usage,Production

Description

24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain. It activates liver X receptors (LXRs) in the developing ventral midbrain to induce stem cell differentiation into dopaminergic neurons. 24(S),25-epoxy Cholesterol inhibits IL-6 production and degranulation of bone marrow-derived murine mast cells that express LXRβ. It inhibits the conversion of desmosterol to cholesterol by 3β-hydroxysterol Δ24-reductase (DHCR24/Seladin-1) in CHO-7 and SRD-1 cells when used at a concentration of 2.5 μM.

Uses

(24S)-24,25-Epoxycholesterol is a derivative of 4β-Hydroxy Cholesterol (H917980), a metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.

Definition

ChEBI: A 3beta-hydroxy steroid that is desmosterol in which the double bond at position 24-25 has been oxidised to the corresponding epoxide (the 24S diastereoisomer). It is an oxysterol agonist of the liver X receptor.

References

1) Chawla et al. (2001), Nuclear receptors and lipid physiology: opening the X-files; Science, 294 1866 2) Brown et al. (2009), 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis; Int. J. Biochem. Cell Biol., 41 744 3) Theofilopoulos et al. (2013), Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis; Nature Chem. Biol., 9 126

24(S),25-Epoxycholesterol (not deuterated) Preparation Products And Raw materials

Raw materials

Preparation Products

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24(S),25-Epoxycholesterol (not deuterated) Suppliers

Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-85370565-229 18080489829
Email
3004654993@qq.com
Country
China
ProdList
8861
Advantage
60
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9353
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58

77058-74-3, 24(S),25-Epoxycholesterol (not deuterated)Related Search:


  • 24(S),25-Epoxycholesterol (not deuterated)
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  • 24(S)
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  • 5-CHOLESTEN-24(S), 25-EPOXY-3β-OL
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  • 77058-74-3