antibiotic 1233A
- Product Name
- antibiotic 1233A
- CAS No.
- 29066-42-0
- Chemical Name
- antibiotic 1233A
- Synonyms
- 699;F-244;1233A;L-659699;Hymeglusin;Antibiotic F-244;antibiotic 1233A;(R,R)-HyMeglusin;(2E,4E,7R)-11-[(2R,3R)-3-Hydroxymethyl-4-oxooxetan-2-yl]-3,5,7-trimethyl-2,4-undecadienoic acid;(2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-2,4-undecadienoic acid
- CBNumber
- CB41355000
- Molecular Formula
- C18H28O5
- Formula Weight
- 324.41
- MOL File
- 29066-42-0.mol
antibiotic 1233A Property
- Boiling point:
- 516.6±15.0 °C(Predicted)
- Density
- 1.101±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble
- form
- powder
- pka
- 4.98±0.33(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety
- WGK Germany
- 3
- RTECS
- YQ1170000
N-Bromosuccinimide Price
- Product number
- SML0301
- Product name
- Hymeglusin
- Purity
- ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $377
- Updated
- 2024/03/01
- Product number
- 11899
- Product name
- Hymeglusin
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $124
- Updated
- 2024/03/01
- Product number
- 11899
- Product name
- Hymeglusin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $211
- Updated
- 2024/03/01
- Product number
- 11899
- Product name
- Hymeglusin
- Purity
- ≥95%
- Packaging
- 2.5mg
- Price
- $496
- Updated
- 2024/03/01
- Product number
- H998033
- Product name
- Hymeglusin
- Packaging
- 0.5mg
- Price
- $580
- Updated
- 2021/12/16
antibiotic 1233A Chemical Properties,Usage,Production
Description
Hymeglusin (29066-42-0) is an inhibitor of eukaryotic mevalonate biosynthesis via inhibition of HMG-CoA synthase, IC50=0.12 μM.1 Acts via covalent modification of the active site Cys129.1,2 Inhibits cholesterol biosynthesis in rats (45% at 25 mg/Kg).1 Also inhibits bacterial HMG-CoA synthase.3 Inhibits dengue virus replication.4
Uses
Hymeglusin is an irreversible HMG-CoA synthase inhibitor.
Definition
ChEBI: Hymeglusin is a long-chain fatty acid.
storage
+4°C
References
1) Greenspan et al. (1987), Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699; Proc. Natl. Acad. Sci. USA, 84 7488 2) Tomoda et al. (2004), Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase; Biochem. Biophys. Acta, 1636 22 3) Skaff et al. (2012), Biochemical and structural basis for inhibition of Enterococcis faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin; Biochemistry, 51 4713 4) Rothwell et al. (2009), Cholesterol biosynthesis modulation regulates dengue viral replication; Virology, 389 8
antibiotic 1233A Preparation Products And Raw materials
Raw materials
Preparation Products
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