ML335
- Product Name
- ML335
- CAS No.
- 825658-06-8
- Chemical Name
- ML335
- Synonyms
- TREK-1/2 Activator;ML335; ML-335; ML 335; TREK-1/2 ACTIVATOR;N-(2,4-Dichlorobenzyl)-4-(methylsulfonamido)benzamide;Potassium Channel,ML-335,ML 335,ML335,KcsA,Inhibitor,inhibit;Benzamide, N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]-
- CBNumber
- CB53373069
- Molecular Formula
- C15H14Cl2N2O3S
- Formula Weight
- 373.25
- MOL File
- 825658-06-8.mol
ML335 Property
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming).
- form
- solid
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 27635
- Product name
- ML335
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 27635
- Product name
- ML335
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 27635
- Product name
- ML335
- Packaging
- 25mg
- Price
- $254
- Updated
- 2024/03/01
- Product number
- 27635
- Product name
- ML335
- Packaging
- 50mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- M425225
- Product name
- ML335
- Packaging
- 5mg
- Price
- $185
- Updated
- 2021/12/16
ML335 Chemical Properties,Usage,Production
Description
Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1?It represents an important new pharmacological tool for studying the physiology of TREK channels.
Uses
ML335, is a selective activator of both TREK-1 and TREK-2.
storage
Store at +4°C
References
1) Lolicato?et al.?(2017),?K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature,?547?364
ML335 Preparation Products And Raw materials
Raw materials
Preparation Products
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