ML418

Product Name: ML418
CAS No.: 1928763-08-9
Chemical Name: ML418
Synonyms: ML418;inhibit,ML-418,ML418,KcsA,ML 418,Inhibitor,Potassium Channel;Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate;Carbamic acid, N-[1-[(5-chloro-8-hydroxy-7-quinolinyl)methyl]-4-piperidinyl]-, 1-methylethyl ester
CBNumber: CB14668207
Molecular Formula: C19H24ClN3O3
Formula Weight: 377.87
MOL File: 1928763-08-9.mol

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ML418 Property

Boiling point:: 545.5±50.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO
pka: 12.43±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 6889
Product name: ML418
Purity: ≥98%(HPLC)
Packaging: 10
Price: $149
Updated: 2021/12/16

ChemScene

Product number: CS-0088425
Product name: ML418
Purity: 99.19%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0088425
Product name: ML418
Purity: 99.19%
Packaging: 5mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0088425
Product name: ML418
Purity: 99.19%
Packaging: 250mg
Price: $1500
Updated: 2021/12/16

Ambeed

Product number: A1251852
Product name: Isopropyl(1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate
Purity: 98%
Packaging: 250mg
Price: $1400
Updated: 2021/12/16

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ML418 Chemical Properties,Usage,Production

Uses

ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker. ML418 inhibits Kir7.1 with an IC50 value of 0.31 μM. ML418 can be used for the research of neurological, cardiovascular, endocrine and muscle disorders.

in vivo

ML418 (i.p.; 30 mg/kg) has good PK effect, excellent CNS penetration and favorable CNS distribution^[1].

Animal Model:	Rats and Mice^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal
Result:	Showed a suitable PK profile (Cmax = 0.20 μM and Tmax = 3 h), excellent CNS penetration with a mouse brain: Kp of 10.9, brain (323.9 ng/g): plasma (29.5 ng/mL).

storage

Store at -20°C

References

[1] ML418, et al. ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23. DOI:10.1021/acschemneuro.6b00111

ML418 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML418 Suppliers

China 35 United States 3 Global 38

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9697
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29661
Advantage: 68

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 1141
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10343
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ML418

Carbamic acid, N-[1-[(5-chloro-8-hydroxy-7-quinolinyl)methyl]-4-piperidinyl]-, 1-methylethyl ester

Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate

inhibit,ML-418,ML418,KcsA,ML 418,Inhibitor,Potassium Channel

1928763-08-9