ML346
- Product Name
- ML346
- CAS No.
- 100872-83-1
- Chemical Name
- ML346
- Synonyms
- ML346;CS-2056;ML346;ML 346;ML346 - CID 767276;ML346, 10 mM in DMSO;5-(3-(4-Methoxyphenyl)allylidene)pyrimidine-2,4,6(1H,3H,5H)-trione;2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-;response,inhibit,probe,protein,Heat shock proteins,Inhibitor,ML346,ML 346,HSP,shock,conformational,cytotoxicity,ML-346,heat,chaperones
- CBNumber
- CB43041431
- Molecular Formula
- C14H12N2O4
- Formula Weight
- 272.26
- MOL File
- 100872-83-1.mol
ML346 Property
- Melting point:
- 266-268 °C(Solv: ethyl acetate (141-78-6))
- Density
- 1.374±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO:8.0(Max Conc. mg/mL);29.38(Max Conc. mM)
- form
- A crystalline solid
- pka
- 7.42±0.20(Predicted)
- color
- Pink to red
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23844
- Product name
- ML-346
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 23844
- Product name
- ML-346
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- 23844
- Product name
- ML-346
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 23844
- Product name
- ML-346
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $266
- Updated
- 2024/03/01
- Product number
- Axon2703
- Product name
- ML346-CID767276
- Purity
- 100%
- Packaging
- 10mg
- Price
- $137.5
- Updated
- 2021/12/16
ML346 Chemical Properties,Usage,Production
Description
ML-346 is an activator of the heat shock response that induces the expression of the heat shock proteins HSP70, HSP40, and HSP27. It induces the expression of the oxidative stress response genes HO1, GCLM, and BiP in mouse embryonic fibroblasts (MEFs) and pretreatment protects cells from severe heat shock-induced death and H2O2-induced apoptosis. It promotes folding of metastable proteins in models of conformational disease, including cellular models of Huntingtin aggregation and cystic fibrosis. It reduces aggregate formation in PC12 cells expressing human Huntingtin exon 1 containing a 74 glutamine expansion when used at a concentration of 10 μM. It also corrects trafficking of cystic fibrosis transmembrane conductance regulator proteins bearing the F508 deletion (ΔF508-CFTR) mutation carried by the majority of cystic fibrosis patients, leading to increased cell surface expression.
Uses
ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27[1].
in vivo
ML346 suppress the aggregation of polyQ35 in a C. elegans model, suggesting the probe has efficacy in modifying protein aggregation and associated toxicity[1].
IC 50
HSP70: 4.6 μM (EC50, HeLa cells)
References
[1] Calamini B, et al. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases.Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 17. PMID:23833797
[2] Calamini B, et al. Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2011 Dec 25;8(2):185-96. DOI:10.1038/nchembio.763
ML346 Preparation Products And Raw materials
Raw materials
Preparation Products
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