ChemicalBook > CAS DataBase List > N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- Product Name
- N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- CAS No.
- 381168-77-0
- Chemical Name
- N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- Synonyms
- ML367;ML367 ，S0161;ML367, 10 mM in DMSO;ML-367,ML367,inhibit,ML 367,Inhibitor;N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine;4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-
- CBNumber
- CB04248334
- Molecular Formula
- C19H12F2N4
- Formula Weight
- 334.32
- MOL File
- 381168-77-0.mol
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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 125 mg/mL (373.89 mM)
- form
- Solid
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
Axon Medchem
- Product number
- Axon2995
- Product name
- ML 367
- Packaging
- 10mg
- Price
- $137.5
- Updated
- 2026/05/19
Axon Medchem
- Product number
- Axon2995
- Product name
- ML 367
- Packaging
- 50mg
- Price
- $467.5
- Updated
- 2026/05/19
ACHEMBLOCK
- Product number
- AD265089
- Product name
- ML367
- Purity
- 98%
- Packaging
- 100MG
- Price
- $390
- Updated
- 2026/05/27
ACHEMBLOCK
- Product number
- AD265089
- Product name
- ML367
- Purity
- 98%
- Packaging
- 250MG
- Price
- $780
- Updated
- 2026/05/27
Arctom
- Product number
- HY-122198
- Product name
- ML367
- Purity
- 99.84%
- Packaging
- 5mg
- Price
- $48
- Updated
- 2026/05/26
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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Chemical Properties,Usage,Production
Uses
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1].
Biological Activity
ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.
in vitro
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.
Western Blot Analysis
< table class="zh_use_1">target
| Target | Value |
| ATAD5 () |