ChemicalBook > CAS DataBase List > N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

Product Name
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
CAS No.
381168-77-0
Chemical Name
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
Synonyms
ML367;ML367 ，S0161;ML367, 10 mM in DMSO;ML-367,ML367,inhibit,ML 367,Inhibitor;N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine;4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-
CBNumber
CB04248334
Molecular Formula
C19H12F2N4
Formula Weight
334.32
MOL File
381168-77-0.mol
More
Less

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Property

storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 125 mg/mL (373.89 mM)
form 
Solid
color 
Light yellow to yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Axon Medchem
Product number
Axon2995
Product name
ML367-CID921541
Purity
99%
Packaging
10mg
Price
$137.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0275430
Product name
N-(3,4-DIFLUOROPHENYL)-2-PYRIDIN-4-YLQUINAZOLIN-4-AMINE
Purity
95.00%
Packaging
5MG
Price
$503.57
Updated
2021/12/16
DC Chemicals
Product number
DC26162
Product name
ML367
Purity
>98%
Packaging
100mg
Price
$650
Updated
2021/12/16
DC Chemicals
Product number
DC26162
Product name
ML367
Purity
>98%
Packaging
1g
Price
$2200
Updated
2021/12/16
More
Less

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Chemical Properties,Usage,Production

Uses

ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1].

Biological Activity

ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.

in vitro

ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.

Western Blot Analysis

< table class="zh_use_1"> Cell Line: HEK293T cells Concentration: 0-40 μM in the presence or absence of 20 μM 5-Furd Incubation Time: 16 hours Result: Inhibited the increased ATAD5 protein levels induced by 5-Furd.

target

References

[1] Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program. PMID:24479200

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Suppliers

China 29 Finland 2 United States 5 Global 36
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4769
Advantage
55
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4810
Advantage
58
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
Advantage
58
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Tel
400-668-6834
Email
info@selleck.cn
Country
China
ProdList
6071
Advantage
58
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
33024
Advantage
60
Tel
18689410811
Country
CHINA
ProdList
178
Advantage
58
Tel
13760798286
Country
CHINA
ProdList
188
Advantage
58
Tel
13822277471
Country
CHINA
ProdList
187
Advantage
58
Tel
13032137268
Email
171198252@qq.com
Country
China
ProdList
130
Advantage
58
Tel
18818417021
Country
CHINA
ProdList
127
Advantage
58
Tel
13580337740
Country
CHINA
ProdList
129
Advantage
58
Tel
--
Fax
--
Email
info@biorbyt.com
Country
CHINA
ProdList
6482
Advantage
58
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

381168-77-0, N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amineRelated Search:

ML346 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098 ML277 ML 204 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 ML-327 PTP1B-IN-2 ML264

  • N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
  • ML367
  • 4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-
  • ML-367,ML367,inhibit,ML 367,Inhibitor
  • ML367, 10 mM in DMSO
  • ML367 ，S0161
  • 381168-77-0
  • C19H12F2N4
    • TargetValue
    ATAD5
    ()