ChemicalBook > CAS DataBase List > N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

Product Name
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
CAS No.
381168-77-0
Chemical Name
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
Synonyms
ML367;ML367, 10 mM in DMSO;ML-367,ML367,inhibit,ML 367,Inhibitor;N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine;4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-
CBNumber
CB04248334
Molecular Formula
C19H12F2N4
Formula Weight
334.32
MOL File
381168-77-0.mol
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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Property

storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 125 mg/mL (373.89 mM)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon2995
Product name
ML367-CID921541
Purity
99%
Packaging
10mg
Price
$137.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0275430
Product name
N-(3,4-DIFLUOROPHENYL)-2-PYRIDIN-4-YLQUINAZOLIN-4-AMINE
Purity
95.00%
Packaging
5MG
Price
$503.57
Updated
2021/12/16
DC Chemicals
Product number
DC26162
Product name
ML367
Purity
>98%
Packaging
100mg
Price
$650
Updated
2021/12/16
DC Chemicals
Product number
DC26162
Product name
ML367
Purity
>98%
Packaging
1g
Price
$2200
Updated
2021/12/16
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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Chemical Properties,Usage,Production

Biological Activity

ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.

in vitro

ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.

Western Blot Analysis

< table class="zh_use_1"> Cell Line: HEK293T cells Concentration: 0-40 μM in the presence or absence of 20 μM 5-Furd Incubation Time: 16 hours Result: Inhibited the increased ATAD5 protein levels induced by 5-Furd.

target

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Suppliers

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381168-77-0, N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amineRelated Search:

ML346 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098 ML277 ML 204 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 ML-327 PTP1B-IN-2 ML264

  • N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
  • ML367
  • 4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-
  • ML-367,ML367,inhibit,ML 367,Inhibitor
  • ML367, 10 mM in DMSO
  • 381168-77-0
  • C19H12F2N4
    • TargetValue
    ATAD5
    ()