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S3I-201

Product Name
S3I-201
CAS No.
501919-59-1
Chemical Name
S3I-201
Synonyms
CS-450;106202;S2I-201;S31-201;S3I-201;NSC 74859;S3I-201, >98%;NSC 74859, >=98%;S3I-201 USP/EP/BP;NSC 74859(S31-201)
CBNumber
CB22452397
Molecular Formula
C16H15NO7S
Formula Weight
365.36
MOL File
501919-59-1.mol
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S3I-201 Property

Melting point:
>185oC (dec.)
Boiling point:
654.7±55.0 °C(Predicted)
Density 
1.507
storage temp. 
-20°C
solubility 
DMSO: >10mg/mL
pka
2.98±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
573102
Product name
STAT3 Inhibitor VI, S3I-201
Packaging
10mg
Price
$245
Updated
2024/03/01
Sigma-Aldrich
Product number
573102
Product name
STAT3 Inhibitor VI, S3I-201
Packaging
25mg
Price
$390
Updated
2024/03/01
Cayman Chemical
Product number
14336
Product name
S3I-201
Purity
≥95%
Packaging
5mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
14336
Product name
S3I-201
Purity
≥95%
Packaging
10mg
Price
$117
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0330
Product name
S3I-201
Purity
≥97% (HPLC)
Packaging
5mg
Price
$110
Updated
2024/03/01
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S3I-201 Chemical Properties,Usage,Production

Uses

A chemical probe inhibitor of STAT3 with an IC50 of 86 μM.

Uses

S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:

  • to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
  • to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
  • to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells

Uses

S2I-201 is a small molecule inhibitor that provides a pathway to rational combination therapies for Melanoma.

Definition

ChEBI: An amidobenzoic acid obtained by formal condensation of the carboxy group of [(4-methylbenzene-1-sulfonyl)oxy]acetic acid with the amino group of 4-amino-2-hydroxybenzoic acid.

Biological Activity

s3i-201 is a selective inhibitor of stat3 with ic50 value of 86 μm [1].in the in vitro stat3 dna-binding assay, s3i-201 showed potent inhibition of the stat3 dna-binding activity with an average ic50 of 86 μm. in the emsa assay, s3i-201 selectively inhibited stat3 dna-binding activity over that of stat1 and stat5. it suppressed the complex formation of stat1-stat3 and stat1-stat1 with ic50 values of 160 and > 300 μm, respectively. besides that, the unphosphorylated, inactive stat3 monomer was found to restore the stat3 dna-binding activity inhibited by s3i-201, suggesting that the inhibition was independent on the activation status. in nih 3t3/v-src fibroblasts, s3i-201 inhibited the constitutive activation of stat3 and reduced the ptyr-705 stat3 levels. moreover, s3i-201 was found to significantly induce apoptosis in cells with constitutively active stat3 at concentration of 30–100 μm. s3i-201 also reduced the expression of cyclin d1, bcl-xl and surviving in these cells [1].

Biochem/physiol Actions

S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.

storage

-20°C

References

[1] siddiquee k, zhang s, guida w c, et al. selective chemical probe inhibitor of stat3, identified through structure-based virtual screening, induces antitumor activity. proceedings of the national academy of sciences, 2007, 104(18): 7391-7396.

S3I-201 Preparation Products And Raw materials

Raw materials

Preparation Products

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S3I-201 Suppliers

Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
ChemShuttle, Inc.
Tel
0510-83588313-802 18800520310;
Email
sales@chemshuttle.com
Country
China
ProdList
2996
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
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View Lastest Price from S3I-201 manufacturers

Career Henan Chemical Co
Product
S3I-201 501919-59-1
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

501919-59-1, S3I-201Related Search:


  • S31-201
  • 2-hydroxy-4-(2-(tosyloxy)acetaMido)benzoic acid
  • NSC 74859 (S3I-201)
  • NSC 74859
  • S3I-201
  • S3I-201 (NSC 74859)
  • 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid
  • S2I-201
  • 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid NSC 74859(S3I-201)
  • 2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid
  • Stat3 Inhibitor I, S3I-201
  • OTAVA-BB 7070707021
  • S31-201 (NSC 74859)
  • NSC 74859, >=98%
  • OTAVA-BB 7070707021S31-201 (NSC 74859),S3I-201
  • Stat3 Inhibitor VI, S3I-201
  • S3I-201, 501919-59-1
  • S3I201; NSC74859; NSC 74859;NSC-74859; S3I 201
  • S3I-201, >98%
  • S3I201; NSC74859; NSC 74859; S3I 201
  • CS-450
  • STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem
  • NSC 74859(S31-201)
  • 106202
  • Benzoic acid, 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-
  • S3I-201 USP/EP/BP
  • STAT3 Inhibitor VI S3I-201 NSC74859 NSC-74859
  • 501919-59-1
  • Inhibitors
  • JAK
  • STAT