S3I-201
- Product Name
- S3I-201
- CAS No.
- 501919-59-1
- Chemical Name
- S3I-201
- Synonyms
- CS-450;106202;S2I-201;S31-201;S3I-201;NSC 74859;S3I-201, >98%;NSC 74859, >=98%;S3I-201 USP/EP/BP;NSC 74859(S31-201)
- CBNumber
- CB22452397
- Molecular Formula
- C16H15NO7S
- Formula Weight
- 365.36
- MOL File
- 501919-59-1.mol
S3I-201 Property
- Melting point:
- >185oC (dec.)
- Boiling point:
- 654.7±55.0 °C(Predicted)
- Density
- 1.507
- storage temp.
- -20°C
- solubility
- DMSO: >10mg/mL
- pka
- 2.98±0.10(Predicted)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 573102
- Product name
- STAT3 Inhibitor VI, S3I-201
- Packaging
- 10mg
- Price
- $245
- Updated
- 2024/03/01
- Product number
- 573102
- Product name
- STAT3 Inhibitor VI, S3I-201
- Packaging
- 25mg
- Price
- $390
- Updated
- 2024/03/01
- Product number
- 14336
- Product name
- S3I-201
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 14336
- Product name
- S3I-201
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- SML0330
- Product name
- S3I-201
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $110
- Updated
- 2024/03/01
S3I-201 Chemical Properties,Usage,Production
Uses
A chemical probe inhibitor of STAT3 with an IC50 of 86 μM.
Uses
S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:
- to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
- to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
- to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells
Uses
S2I-201 is a small molecule inhibitor that provides a pathway to rational combination therapies for Melanoma.
Definition
ChEBI: An amidobenzoic acid obtained by formal condensation of the carboxy group of [(4-methylbenzene-1-sulfonyl)oxy]acetic acid with the amino group of 4-amino-2-hydroxybenzoic acid.
Biological Activity
s3i-201 is a selective inhibitor of stat3 with ic50 value of 86 μm [1].in the in vitro stat3 dna-binding assay, s3i-201 showed potent inhibition of the stat3 dna-binding activity with an average ic50 of 86 μm. in the emsa assay, s3i-201 selectively inhibited stat3 dna-binding activity over that of stat1 and stat5. it suppressed the complex formation of stat1-stat3 and stat1-stat1 with ic50 values of 160 and > 300 μm, respectively. besides that, the unphosphorylated, inactive stat3 monomer was found to restore the stat3 dna-binding activity inhibited by s3i-201, suggesting that the inhibition was independent on the activation status. in nih 3t3/v-src fibroblasts, s3i-201 inhibited the constitutive activation of stat3 and reduced the ptyr-705 stat3 levels. moreover, s3i-201 was found to significantly induce apoptosis in cells with constitutively active stat3 at concentration of 30–100 μm. s3i-201 also reduced the expression of cyclin d1, bcl-xl and surviving in these cells [1].
Biochem/physiol Actions
S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.
storage
-20°C
References
[1] siddiquee k, zhang s, guida w c, et al. selective chemical probe inhibitor of stat3, identified through structure-based virtual screening, induces antitumor activity. proceedings of the national academy of sciences, 2007, 104(18): 7391-7396.
S3I-201 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from S3I-201 manufacturers
- Product
- S3I-201 501919-59-1
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2022-10-18
- Product
- S3I-201 501919-59-1
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05