NSC745887

Product Name: NSC745887
CAS No.: 54490-26-5
Chemical Name: NSC745887
Synonyms: NSC745887;Naphtho[2,3-f]quinoxaline-7,12-dione
CBNumber: CB05832808
Molecular Formula: C16H8N2O2
Formula Weight: 260.25
MOL File: 54490-26-5.mol

More

Less

NSC745887 Property

Melting point:: 241-242 °C(Solv: dichloromethane (75-09-2))
Boiling point:: 491.6±40.0 °C(Predicted)
Density: 1.448±0.06 g/cm3(Predicted)
pka: -2.36±0.20(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

CSNpharm

Product number: CSN25281
Product name: NSC745887
Packaging: 5mg
Price: $45
Updated: 2021/12/16

More

Less

NSC745887 Chemical Properties,Usage,Production

Uses

NSC745887 (compound 25) is an inhibitor that targets DNA topoisomerase cleavage, activates the caspase-8/9-caspase-3-poly (ADP-ribose) polymerase cascade, and induces apoptosis in cancer cells. NSC745887 enhances γH2AX expression and causes DNA fragmentation leading to DNA damage[1][2].

References

[1] Fann LY, et al. Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget. 2017 Dec 27;9(15):11922-11937. DOI:10.18632/oncotarget.23714
[2] Huang HS, et al. Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues. Bioorg Med Chem. 2009;17(21):7418-7428. DOI:10.1016/j.bmc.2009.09.033

NSC745887 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

NSC745887 Suppliers

China 8 United States 1 Global 9

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Fine Biotech Co.，Ltd

Tel: 18221172427
Email: sale@fine-biotech.com
Country: China
ProdList: 2772
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19962
Advantage: 58

54490-26-5, NSC745887Related Search:

NSC59984 NSC319726 2-Pyridinecarbothioamide, N-2-pyridinyl- S3I-201 NSC 38280

NSC745887

Naphtho[2,3-f]quinoxaline-7,12-dione

54490-26-5