S3I-201

ChemicalBook > CAS DataBase List > S3I-201

Product Name: S3I-201
CAS No.: 501919-59-1
Chemical Name: S3I-201
Synonyms: CS-450;106202;S2I-201;S31-201;S3I-201;NSC 74859;S3I-201, >98%;NSC 74859, >=98%;S3I-201 USP/EP/BP;NSC 74859(S31-201)
CBNumber: CB22452397
Molecular Formula: C16H15NO7S
Formula Weight: 365.36
MOL File: 501919-59-1.mol

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S3I-201 Property

Melting point:: >185oC (dec.)
Boiling point:: 654.7±55.0 °C(Predicted)
Density: 1.507
storage temp.: -20°C
solubility: DMSO: >10mg/mL
pka: 2.98±0.10(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 573102
Product name: STAT3 Inhibitor VI, S3I-201
Packaging: 10mg
Price: $245
Updated: 2024/03/01

Sigma-Aldrich

Product number: 573102
Product name: STAT3 Inhibitor VI, S3I-201
Packaging: 25mg
Price: $390
Updated: 2024/03/01

Cayman Chemical

Product number: 14336
Product name: S3I-201
Purity: ≥95%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 14336
Product name: S3I-201
Purity: ≥95%
Packaging: 10mg
Price: $117
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0330
Product name: S3I-201
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $110
Updated: 2024/03/01

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S3I-201 Chemical Properties,Usage,Production

Uses

A chemical probe inhibitor of STAT3 with an IC50 of 86 μM.

Uses

S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:

to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells

Uses

S2I-201 is a small molecule inhibitor that provides a pathway to rational combination therapies for Melanoma.

Definition

ChEBI: An amidobenzoic acid obtained by formal condensation of the carboxy group of [(4-methylbenzene-1-sulfonyl)oxy]acetic acid with the amino group of 4-amino-2-hydroxybenzoic acid.

Biological Activity

s3i-201 is a selective inhibitor of stat3 with ic50 value of 86 μm [1].in the in vitro stat3 dna-binding assay, s3i-201 showed potent inhibition of the stat3 dna-binding activity with an average ic50 of 86 μm. in the emsa assay, s3i-201 selectively inhibited stat3 dna-binding activity over that of stat1 and stat5. it suppressed the complex formation of stat1-stat3 and stat1-stat1 with ic50 values of 160 and > 300 μm, respectively. besides that, the unphosphorylated, inactive stat3 monomer was found to restore the stat3 dna-binding activity inhibited by s3i-201, suggesting that the inhibition was independent on the activation status. in nih 3t3/v-src fibroblasts, s3i-201 inhibited the constitutive activation of stat3 and reduced the ptyr-705 stat3 levels. moreover, s3i-201 was found to significantly induce apoptosis in cells with constitutively active stat3 at concentration of 30–100 μm. s3i-201 also reduced the expression of cyclin d1, bcl-xl and surviving in these cells [1].

Biochem/physiol Actions

S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.

storage

-20°C

References

[1] siddiquee k, zhang s, guida w c, et al. selective chemical probe inhibitor of stat3, identified through structure-based virtual screening, induces antitumor activity. proceedings of the national academy of sciences, 2007, 104(18): 7391-7396.

S3I-201 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from S3I-201 manufacturers

Career Henan Chemical Co

Product: S3I-201 501919-59-1
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

501919-59-1, S3I-201Related Search:

NSC745887 NSC319726 2,4-Thiazolidinedione,5-[(4-hydroxy-3-methoxyphenyl)methylene]- 4-Chloro-N,N-diisopropylbenzamide Pifithrin-μ 2-Pyridinecarbothioamide, N-2-pyridinyl- 1,3-Bis(4-aminophenyl)urea 5-(4-iodobenzylidene)rhodanine NSC228155 NSC632839hydrochloride NSC23005 Sodium HAMNO NSC 247030 5-[(4-chlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione Fludarabine Stattic Dasatinib NSC781406

S31-201

2-hydroxy-4-(2-(tosyloxy)acetaMido)benzoic acid

NSC 74859 (S3I-201)

NSC 74859

S3I-201

S3I-201 (NSC 74859)

2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid

S2I-201

2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid NSC 74859(S3I-201)

2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid

Stat3 Inhibitor I, S3I-201

OTAVA-BB 7070707021

S31-201 (NSC 74859)

NSC 74859, >=98%

OTAVA-BB 7070707021S31-201 (NSC 74859)，S3I-201

Stat3 Inhibitor VI, S3I-201

S3I-201, 501919-59-1

S3I201; NSC74859; NSC 74859;NSC-74859; S3I 201

S3I-201, >98%

S3I201; NSC74859; NSC 74859; S3I 201

CS-450

STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem

NSC 74859(S31-201)

106202

Benzoic acid, 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-

S3I-201 USP/EP/BP

STAT3 Inhibitor VI S3I-201 NSC74859 NSC-74859

S3I-201 (DMSO solution), STAT3 inhibitor

S3I-201, STAT3 inhibitor

S3I-201, 10 mM in DMSO

501919-59-1

Inhibitors

JAK

STAT