ChemicalBook > CAS DataBase List > NSC228155

NSC228155

Product Name
NSC228155
CAS No.
113104-25-9
Chemical Name
NSC228155
Synonyms
NSC228155;NSC-228155;NSC 228155;NSC228155;NSC-228155;NSC 228155;2,1,3-Benzoxadiazole, 4-nitro-7-[(1-oxido-2-pyridinyl)thio]-;2-[(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio]pyridine 1-oxide;Epidermal growth factor receptor,Histone Acetyltransferase,EGFR,HER1,HATs,inhibit,Inhibitor,NSC-228155,HAT,Epigenetic Reader Domain,NSC 228155,ErbB-1
CBNumber
CB13159458
Molecular Formula
C11H6N4O4S
Formula Weight
290.25
MOL File
113104-25-9.mol
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NSC228155 Property

Boiling point:
627.3±65.0 °C(Predicted)
Density 
1.72±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
≥29 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
pka
-1.48±0.10(Predicted)
color 
Light yellow to orange
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28856
Product name
NSC 228155
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
28856
Product name
NSC 228155
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
28856
Product name
NSC 228155
Packaging
25mg
Price
$235
Updated
2024/03/01
ChemScene
Product number
CS-0020796
Product name
NSC228155
Purity
>98.0%
Packaging
5mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0020796
Product name
NSC228155
Purity
>98.0%
Packaging
50mg
Price
$280
Updated
2021/12/16
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NSC228155 Chemical Properties,Usage,Production

Biological Activity

nsc228155 is a potent inhibitor of kix-kid interaction.cyclic-amp response-element binding protein (creb) is identified as a stimulus-activated transcription factor. its transcription activity needs its binding with creb-binding protein (cbp) after creb is phosphorylated at ser133. the domains involved for creb-cbp interaction are kinase-inducible domain (kid) from creb and kid-interacting domain (kix) from cbp.

in vitro

previous study found that nsc228155 could dose-dependently inhibit kix–kid interaction as measured by the split rluc assay. in living hek 293t cells, nsc228155 could inhibit creb-mediated gene transcription with an ic50 of 2.09 μm. nsc228155 also inhibited vp16-creb-mediated gene transcription with an ic50 of 6.14 μm. though this was around 3-fold higher than the ic50 of creb-mediated gene transcription, such results indicated that nsc228155 was not particularly selective in inhibiting kix–kid interaction inside these living cells. therefore, although nsc228155 was a potent inhibitor of kix-kid interaction, it was not selective against creb-mediated gene transcription, and further sar studies identified a 4-aniline substituted analog displaying a higher selectivity index [1].

target

EGFR

KIX-KID

0.36 μM (IC 50 )

IC 50

0.36 μm for kix-kid interaction

References

[1] xie f, li bx, broussard c, xiao x. identification, synthesis and evaluation of substituted benzofurazans as inhibitors of creb-mediated gene transcription. bioorg med chem lett. 2013 oct 1;23(19):5371-5.

NSC228155 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC228155 Suppliers

Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9204
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3251
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58

113104-25-9, NSC228155Related Search:


  • NSC228155
  • NSC228155;NSC-228155;NSC 228155
  • 2-[(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio]pyridine 1-oxide
  • NSC-228155;NSC 228155
  • Epidermal growth factor receptor,Histone Acetyltransferase,EGFR,HER1,HATs,inhibit,Inhibitor,NSC-228155,HAT,Epigenetic Reader Domain,NSC 228155,ErbB-1
  • 2,1,3-Benzoxadiazole, 4-nitro-7-[(1-oxido-2-pyridinyl)thio]-
  • 113104-25-9