NSC228155

ChemicalBook > CAS DataBase List > NSC228155

Product Name: NSC228155
CAS No.: 113104-25-9
Chemical Name: NSC228155
Synonyms: NSC228155;NSC-228155;NSC 228155;NSC228155;NSC-228155;NSC 228155;2,1,3-Benzoxadiazole, 4-nitro-7-[(1-oxido-2-pyridinyl)thio]-;2-[(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio]pyridine 1-oxide;Epidermal growth factor receptor,Histone Acetyltransferase,EGFR,HER1,HATs,inhibit,Inhibitor,NSC-228155,HAT,Epigenetic Reader Domain,NSC 228155,ErbB-1
CBNumber: CB13159458
Molecular Formula: C11H6N4O4S
Formula Weight: 290.25
MOL File: 113104-25-9.mol

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NSC228155 Property

Boiling point:: 627.3±65.0 °C(Predicted)
Density: 1.72±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: ≥29 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: -1.48±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28856
Product name: NSC 228155
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 28856
Product name: NSC 228155
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 28856
Product name: NSC 228155
Packaging: 25mg
Price: $235
Updated: 2024/03/01

ChemScene

Product number: CS-0020796
Product name: NSC228155
Purity: >98.0%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0020796
Product name: NSC228155
Purity: >98.0%
Packaging: 50mg
Price: $280
Updated: 2021/12/16

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NSC228155 Chemical Properties,Usage,Production

Biological Activity

nsc228155 is a potent inhibitor of kix-kid interaction.cyclic-amp response-element binding protein (creb) is identified as a stimulus-activated transcription factor. its transcription activity needs its binding with creb-binding protein (cbp) after creb is phosphorylated at ser133. the domains involved for creb-cbp interaction are kinase-inducible domain (kid) from creb and kid-interacting domain (kix) from cbp.

in vitro

previous study found that nsc228155 could dose-dependently inhibit kix–kid interaction as measured by the split rluc assay. in living hek 293t cells, nsc228155 could inhibit creb-mediated gene transcription with an ic50 of 2.09 μm. nsc228155 also inhibited vp16-creb-mediated gene transcription with an ic50 of 6.14 μm. though this was around 3-fold higher than the ic50 of creb-mediated gene transcription, such results indicated that nsc228155 was not particularly selective in inhibiting kix–kid interaction inside these living cells. therefore, although nsc228155 was a potent inhibitor of kix-kid interaction, it was not selective against creb-mediated gene transcription, and further sar studies identified a 4-aniline substituted analog displaying a higher selectivity index [1].

target

EGFR	KIX-KID 0.36 μM (IC ₅₀ )

IC 50

0.36 μm for kix-kid interaction

References

[1] xie f, li bx, broussard c, xiao x. identification, synthesis and evaluation of substituted benzofurazans as inhibitors of creb-mediated gene transcription. bioorg med chem lett. 2013 oct 1;23(19):5371-5.

NSC228155 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC228155

NSC228155;NSC-228155;NSC 228155

2-[(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio]pyridine 1-oxide

NSC-228155;NSC 228155

Epidermal growth factor receptor,Histone Acetyltransferase,EGFR,HER1,HATs,inhibit,Inhibitor,NSC-228155,HAT,Epigenetic Reader Domain,NSC 228155,ErbB-1

2,1,3-Benzoxadiazole, 4-nitro-7-[(1-oxido-2-pyridinyl)thio]-

113104-25-9