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NSC632839hydrochloride

Product Name
NSC632839hydrochloride
CAS No.
157654-67-6
Chemical Name
NSC632839hydrochloride
Synonyms
NSC 632839;NSC632839 HCl;NSC 632839;NSC-632839;NSC632839hydrochloride;Ubiquitin Isopeptidase Inhibitor II;Ubiquitin Isopeptidase Inhibitor II, F6;3,5-Bis(4-methylbenzylidene)piperidin-4-one hydrochloride;3,5-Bis[(4-methylphenyl)methylene]-4-piperidonehydrochloride;4-Piperidione,3,5-bis[(4-methylphenyl)methylene] hydrochloride;4-Piperidinone, 3,5-bis[(4-methylphenyl)methylene]-, hydrochloride (1:1)
CBNumber
CB11075088
Molecular Formula
C21H21NO.ClH
Formula Weight
339.864
MOL File
157654-67-6.mol
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NSC632839hydrochloride Property

storage temp. 
Store at +4°C
solubility 
DMSO: ≥2mg/mL (warmed)
form 
powder
color 
faint yellow to dark yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Safety

Hazard Codes 
Xi,N
Risk Statements 
36-51/53
Safety Statements 
26-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0270
Product name
NSC 632839
Purity
≥98% (HPLC)
Packaging
5mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0270
Product name
NSC 632839
Purity
≥98% (HPLC)
Packaging
25mg
Price
$392
Updated
2022/05/15
Cayman Chemical
Product number
16893
Product name
NSC 632839
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16893
Product name
NSC 632839
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
16893
Product name
NSC 632839
Purity
≥98%
Packaging
25mg
Price
$230
Updated
2024/03/01
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NSC632839hydrochloride Chemical Properties,Usage,Production

Description

NSC-632839 (157654-67-6) is a pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. NSC-632839 induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.1,2?Cell permeable.

Uses

Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 μM, respectively. It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 μM in cells sensitized by E1A, an adenoviral oncogene).

Biological Activity

Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC 50 values are 15.65 and 16.23 μ M in E1A and E1A/C9CN cells respectively).

References

1) Aleo et al. (2006), Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis; Cancer Res., 66 9235 2) Nicholson et al. (2008), Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities; Protein Sci. 17 1035

NSC632839hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC632839hydrochloride Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Shanghai Synteam Biochem CO.,ltd
Tel
+86-021-58380978 +86-18017016373
Fax
021-58380978
Email
info@systeambc.com
Country
China
ProdList
941
Advantage
50
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9204
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68

157654-67-6, NSC632839hydrochlorideRelated Search:


  • Ubiquitin Isopeptidase Inhibitor II, F6
  • NSC 632839
  • 4-Piperidione,3,5-bis[(4-methylphenyl)methylene] hydrochloride
  • NSC 632839;NSC-632839
  • NSC632839hydrochloride
  • 3,5-Bis[(4-methylphenyl)methylene]-4-piperidonehydrochloride
  • Ubiquitin Isopeptidase Inhibitor II
  • NSC632839 HCl
  • 3,5-Bis(4-methylbenzylidene)piperidin-4-one hydrochloride
  • 4-Piperidinone, 3,5-bis[(4-methylphenyl)methylene]-, hydrochloride (1:1)
  • 157654-67-6
  • C21H21NOHCl