NSC632839hydrochloride

ChemicalBook > CAS DataBase List > NSC632839hydrochloride

NSC632839hydrochloride

Product Name: NSC632839hydrochloride
CAS No.: 157654-67-6
Chemical Name: NSC632839hydrochloride
Synonyms: NSC 632839;NSC632839 HCl;NSC 632839;NSC-632839;NSC632839hydrochloride;Ubiquitin Isopeptidase Inhibitor II;Ubiquitin Isopeptidase Inhibitor II, F6;3,5-Bis(4-methylbenzylidene)piperidin-4-one hydrochloride;3,5-Bis[(4-methylphenyl)methylene]-4-piperidonehydrochloride;4-Piperidione,3,5-bis[(4-methylphenyl)methylene] hydrochloride
CBNumber: CB11075088
Molecular Formula: C21H21NO.ClH
Formula Weight: 339.864
MOL File: 157654-67-6.mol

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NSC632839hydrochloride Property

storage temp.: Store at +4°C
solubility: DMSO: ≥2mg/mL (warmed)
form: powder
color: faint yellow to dark yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

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Safety

Hazard Codes: Xi,N
Risk Statements: 36-51/53
Safety Statements: 26-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0270
Product name: NSC 632839
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0270
Product name: NSC 632839
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $392
Updated: 2022/05/15

Cayman Chemical

Product number: 16893
Product name: NSC 632839
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16893
Product name: NSC 632839
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16893
Product name: NSC 632839
Purity: ≥98%
Packaging: 25mg
Price: $230
Updated: 2024/03/01

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NSC632839hydrochloride Chemical Properties,Usage,Production

Description

NSC-632839 (157654-67-6) is a pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. NSC-632839 induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.1,2?Cell permeable.

Uses

Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 μM, respectively. It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 μM in cells sensitized by E1A, an adenoviral oncogene).

Biological Activity

Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC 50 values are 15.65 and 16.23 μ M in E1A and E1A/C9CN cells respectively).

References

1) Aleo et al. (2006), Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis; Cancer Res., 66 9235 2) Nicholson et al. (2008), Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities; Protein Sci. 17 1035

NSC632839hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC632839hydrochloride Suppliers

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157654-67-6, NSC632839hydrochlorideRelated Search:

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Ubiquitin Isopeptidase Inhibitor II, F6

NSC 632839

4-Piperidione,3,5-bis[(4-methylphenyl)methylene] hydrochloride

NSC 632839;NSC-632839

NSC632839hydrochloride

3,5-Bis[(4-methylphenyl)methylene]-4-piperidonehydrochloride

Ubiquitin Isopeptidase Inhibitor II

NSC632839 HCl

3,5-Bis(4-methylbenzylidene)piperidin-4-one hydrochloride

157654-67-6

C21H21NOHCl