ChemicalBook > CAS DataBase List > NSC632839hydrochloride

NSC632839hydrochloride

Product Name
NSC632839hydrochloride
CAS No.
157654-67-6
Chemical Name
NSC632839hydrochloride
Synonyms
NSC 632839;NSC632839 HCl;NSC 632839 ，S4922;NSC 632839;NSC-632839;NSC632839hydrochloride;NSC632839, 10 mM in DMSO;Ubiquitin Isopeptidase Inhibitor II;Ubiquitin Isopeptidase Inhibitor II, F6;NSC-632839, ubiquitin isopeptidase inhibitor;3,5-Bis(4-methylbenzylidene)piperidin-4-one hydrochloride
CBNumber
CB11075088
Molecular Formula
C21H21NO.ClH
Formula Weight
339.864
MOL File
157654-67-6.mol
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NSC632839hydrochloride Property

storage temp. 
Store at +4°C
solubility 
DMSO: ≥2mg/mL (warmed)
form 
powder
color 
faint yellow to dark yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Safety

Hazard Codes 
Xi,N
Risk Statements 
36-51/53
Safety Statements 
26-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0270
Product name
NSC 632839
Purity
≥98% (HPLC)
Packaging
5mg
Price
$96.1
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0270
Product name
NSC 632839
Purity
≥98% (HPLC)
Packaging
25mg
Price
$392
Updated
2022/05/15
Cayman Chemical
Product number
16893
Product name
NSC 632839
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16893
Product name
NSC 632839
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
16893
Product name
NSC 632839
Purity
≥98%
Packaging
25mg
Price
$230
Updated
2024/03/01
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NSC632839hydrochloride Chemical Properties,Usage,Production

Description

NSC-632839 (157654-67-6) is a pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. NSC-632839 induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.1,2?Cell permeable.

Uses

Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 μM, respectively. It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 μM in cells sensitized by E1A, an adenoviral oncogene).

Biological Activity

Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC 50 values are 15.65 and 16.23 μ M in E1A and E1A/C9CN cells respectively).

References

[1] EMANUELA ALEO. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.[J]. Cancer research, 2006: 9235-9244. DOI:10.1158/0008-5472.can-06-0702
[2] BENJAMIN NICHOLSON. Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities.[J]. Protein Science, 2008, 17 6: 1035-1043. DOI:10.1110/ps.083450408

NSC632839hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC632839hydrochloride Suppliers

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157654-67-6, NSC632839hydrochlorideRelated Search:

5-(2-HYDROXY-BENZYLIDENE)-THIAZOLIDINE-2,4-DIONE 4-Chloro-N,N-diethylbenzaMide, 97% 4-Chloro-N,N-di-n-propylbenzaMide, 97% TIMTEC-BB SBB006342 NSC781406 2,4-Thiazolidinedione,5-[(4-hydroxy-3-methoxyphenyl)methylene]- 4-Chloro-N,N-diisopropylbenzamide Pifithrin-μ 2-Pyridinecarbothioamide, N-2-pyridinyl- 1,3-Bis(4-aminophenyl)urea 5-(4-iodobenzylidene)rhodanine S3I-201 NSC228155 NSC23005 Sodium HAMNO NSC 247030 CP671305 NSC 42834

  • Ubiquitin Isopeptidase Inhibitor II, F6
  • NSC 632839
  • 4-Piperidione,3,5-bis[(4-methylphenyl)methylene] hydrochloride
  • NSC 632839;NSC-632839
  • NSC632839hydrochloride
  • 3,5-Bis[(4-methylphenyl)methylene]-4-piperidonehydrochloride
  • Ubiquitin Isopeptidase Inhibitor II
  • NSC632839 HCl
  • 3,5-Bis(4-methylbenzylidene)piperidin-4-one hydrochloride
  • 4-Piperidinone, 3,5-bis[(4-methylphenyl)methylene]-, hydrochloride (1:1)
  • NSC-632839, ubiquitin isopeptidase inhibitor
  • NSC632839, 10 mM in DMSO
  • NSC 632839 ，S4922
  • 157654-67-6
  • C21H21NOHCl