GW 3965 HYDROCHLORIDE
- Product Name
- GW 3965 HYDROCHLORIDE
- CAS No.
- 405911-17-3
- Chemical Name
- GW 3965 HYDROCHLORIDE
- Synonyms
- CS-742;GW3965 HCl;GW3965 HCl Salt;W 3965 HYDROCHLORIDE;GW3965 hydrochloride, >=98%;GW-3965 hydrochloride GW3965;GW 3965 HYDROCHLORIDE; GW-3965 HYDROCHLORIDE;;3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…;2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylet...;3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenylacetic Acid Hydrochloride
- CBNumber
- CB5972490
- Molecular Formula
- C33H31ClF3NO3.HCl
- Formula Weight
- 0
- MOL File
- 405911-17-3.mol
GW 3965 HYDROCHLORIDE Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- color
- white
- InChIKey
- NMPUWJFHNOUNQU-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- G6295
- Product name
- GW3965 hydrochloride
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $206
- Updated
- 2024/03/01
- Product number
- G6295
- Product name
- GW3965 hydrochloride
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $702
- Updated
- 2024/03/01
- Product number
- 10054
- Product name
- GW 3965 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $39
- Updated
- 2024/03/01
- Product number
- 10054
- Product name
- GW 3965 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 10054
- Product name
- GW 3965 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $175
- Updated
- 2024/03/01
GW 3965 HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.
Biochem/physiol Actions
GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.
storage
Desiccate at RT
GW 3965 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
GW 3965 HYDROCHLORIDE Suppliers
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View Lastest Price from GW 3965 HYDROCHLORIDE manufacturers
- Product
- GW 3965 HYDROCHLORIDE 405911-17-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 20tons
- Release date
- 2020-01-08