2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

Product Name: 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
CAS No.: 404951-53-7
Chemical Name: 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
Synonyms: dacinostat;NVP-LAQ824;LAQ-824;CS-1101;Danosta;Danosat;Danostha;Danoselta;LAQ-824 Danosta;LAQ-824 Danos he
CBNumber: CB1950386
Molecular Formula: C22H25N3O3
Formula Weight: 379.45
MOL File: 404951-53-7.mol

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2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- Property

Density: 1.290±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥17.45 mg/mL in DMSO
form: solid
pka: 8.81±0.23(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16427
Product name: LAQ824
Purity: ≥95%
Packaging: 1mg
Price: $35
Updated: 2024/03/01

Cayman Chemical

Product number: 16427
Product name: LAQ824
Purity: ≥95%
Packaging: 5mg
Price: $123
Updated: 2024/03/01

Cayman Chemical

Product number: 16427
Product name: LAQ824
Purity: ≥95%
Packaging: 10mg
Price: $210
Updated: 2024/03/01

TRC

Product number: D101580
Product name: Dacinostat
Packaging: 25mg
Price: $220
Updated: 2021/12/16

Usbiological

Product number: 474090
Product name: Dacinostat
Packaging: 100mg
Price: $1423
Updated: 2021/12/16

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2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- Chemical Properties,Usage,Production

Uses

Dacinostat is an inhibitors of aberrant chromatin accessibility. It is also used in the synthesis of triazole-linked indole and oxindole glycoconjugates as potential anticancer agents that inhibits the proliferation of the growth of cancer cell lines.

Definition

ChEBI: N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide is a member of tryptamines.

Biological Activity

laq824 (also known as nvp-laq824 or dacinostat), a derivative of 4-aminomethylcinnamic hydroxamic acid, is a novel and potent inhibitor of histone deacetylase (hdac) that inhibits the activity of hdac with 50% inhibition concentration ic50 value of 0.03 μm. laq824 has been found to inhibit the growth of a variety of cancer cell lines, including colon cancer h1299 and hct116 cells, breast cancer mda435 cells, prostate cancer du145 and pc3 cells and non-small cell lung cancer a549 cells, with ic50 value < 1 μm and induce apoptosis in human breast cancer skbr-3, bt-474 and mb-468 cells. laq824 also dose- and time-dependently inhibits the growth of multiple myeloma cells.catley l, weisberg e, tai yt, atadja p, remiszewski s, hideshima t, mitsiades n, shringarpure r, leblanc r, chauhan d, munshi nc, schlossman r, richardson p, griffin j, anderson kc. nvp-laq824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. blood. 2003 oct 1;102(7):2615-22. epub 2003 jun 19.

target

HDAC

2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- Suppliers

China 92 India 1 United Kingdom 1 United States 15 Global 109

Shanghai Boyle Chemical Co., Ltd.

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ProdList: 2922
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Dalian Meilun Biotech Co., Ltd.

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NCE Biomedical Co.,Ltd.

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MedChemexpress LLC

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Nanjing Chalf-Pharm Technology Co., Ltd.

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View Lastest Price from 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- 404951-53-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

Career Henan Chemical Co

Product: 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- 404951-53-7
Price: US $1.00/g
Min. Order: 100g
Purity: 98%min
Supply Ability: G/KG/T
Release date: 2019-12-20

404951-53-7, 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-Related Search:

Dideoxyinosine Panobinostat Tacedinaline JNJ-26481585 Mocetinostat (MGCD0103) Belinostat (PXD101) CRA-02478 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- cinnamoylhydroxamic acid (DIMETHYLAMINOMETHYL)STYRENE

2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

Dacinostat(NVP-LAQ 824)

LAQ-824

LAQ824 (Dacinostat)

(E)-3-(4-(((2-(1H-indol-3-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide

(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]meth yl]phenyl]prop-2-enamide

dacinostat

3-[4-[N-(2-Hydroxyethyl)-N-[2-(1H-indol-3-yl)ethyl]aminomethyl]phenyl]-2(E)-propenohydroxamic acid

LAQ824(NVP-LAQ824,Dacinostat)

LAQ824 (NVP-LAQ824)

NVP-LAQ824

Dacinostat(LAQ824)

NVP-LAQ824,Dacinostat

Dacinostat (NVP-LAQ824, LAQ824)

CS-1101

NVP-LAQ824; LAQ824; LAQ 824; LAQ-824

Danoselta

Danosta

LAQ-824 Danosta

Danosat

Danostha

LAQ-824 Danos he

404951-53-7

Inhibitors

Inhibitor