GW 3965 HYDROCHLORIDE

ChemicalBook > CAS DataBase List > GW 3965 HYDROCHLORIDE

GW 3965 HYDROCHLORIDE

Product Name: GW 3965 HYDROCHLORIDE
CAS No.: 405911-17-3
Chemical Name: GW 3965 HYDROCHLORIDE
Synonyms: CS-742;GW3965 HCl;GW3965 HCl Salt;W 3965 HYDROCHLORIDE;GW3965 hydrochloride, >=98%;GW-3965 hydrochloride GW3965;GW 3965 hydrochloride, LXR agonist;GW 3965 HYDROCHLORIDE; GW-3965 HYDROCHLORIDE;;3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…;2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylet...
CBNumber: CB5972490
Molecular Formula: C33H31ClF3NO3.HCl
Formula Weight: 0
MOL File: 405911-17-3.mol

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GW 3965 HYDROCHLORIDE Property

storage temp.: Store at -20°C
solubility: DMSO: ≥20mg/mL
form: powder
color: white
InChIKey: NMPUWJFHNOUNQU-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G6295
Product name: GW3965 hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $206
Updated: 2024/03/01

Sigma-Aldrich

Product number: G6295
Product name: GW3965 hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $702
Updated: 2024/03/01

Cayman Chemical

Product number: 10054
Product name: GW 3965 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $39
Updated: 2024/03/01

Cayman Chemical

Product number: 10054
Product name: GW 3965 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 10054
Product name: GW 3965 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $175
Updated: 2024/03/01

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GW 3965 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.

Biochem/physiol Actions

GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.

storage

Desiccate at RT

GW 3965 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GW 3965 HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: GW 3965 HYDROCHLORIDE 405911-17-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-01-08

405911-17-3, GW 3965 HYDROCHLORIDERelated Search:

Trichlorofluoromethane Trifluoromethanesulfonyl chloride TRIFLUOROMETHYLSULPHENYL CHLORIDE Axitinib Carboplatin T0070907 PD 0325901 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- Crizotinib 3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE

3-[3-[n-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride

3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…

GW3965 HCl

2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid hydrochloride

GW3965 hydrochloride, >=98%

Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride

GW3965 HCl Salt

3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride

CS-742

GW 3965 HYDROCHLORIDE; GW-3965 HYDROCHLORIDE;

3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenylacetic Acid Hydrochloride

2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylet...

GW-3965 hydrochloride GW3965

Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride (1:1)

3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-Benzeneacetic acid hydrochloride (1:1)

W 3965 HYDROCHLORIDE

GW 3965 hydrochloride, LXR agonist

405911-17-3

C33H31F3ClNO3HCl

Inhibitors