ChemicalBook > CAS DataBase List > GW 3965 HYDROCHLORIDE

GW 3965 HYDROCHLORIDE

Product Name
GW 3965 HYDROCHLORIDE
CAS No.
405911-17-3
Chemical Name
GW 3965 HYDROCHLORIDE
Synonyms
CS-742;GW3965 HCl;GW3965 HCl Salt;W 3965 HYDROCHLORIDE;GW3965 hydrochloride, >=98%;GW-3965 hydrochloride GW3965;GW 3965 HYDROCHLORIDE; GW-3965 HYDROCHLORIDE;;3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…;2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylet...;3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenylacetic Acid Hydrochloride
CBNumber
CB5972490
Molecular Formula
C33H31ClF3NO3.HCl
Formula Weight
0
MOL File
405911-17-3.mol
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GW 3965 HYDROCHLORIDE Property

storage temp. 
Store at -20°C
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
white
InChIKey
NMPUWJFHNOUNQU-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
26-39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G6295
Product name
GW3965 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$206
Updated
2024/03/01
Sigma-Aldrich
Product number
G6295
Product name
GW3965 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$702
Updated
2024/03/01
Cayman Chemical
Product number
10054
Product name
GW 3965 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$39
Updated
2024/03/01
Cayman Chemical
Product number
10054
Product name
GW 3965 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
10054
Product name
GW 3965 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$175
Updated
2024/03/01
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GW 3965 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.

Biochem/physiol Actions

GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.

storage

Desiccate at RT

GW 3965 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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GW 3965 HYDROCHLORIDE Suppliers

China 100 India 2 Switzerland 1 The Netherlands 1 United Kingdom 2 United States 14 Global 120
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View Lastest Price from GW 3965 HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
GW 3965 HYDROCHLORIDE 405911-17-3
Price
US $1.00/KG
Min. Order
1KG
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-01-08

405911-17-3, GW 3965 HYDROCHLORIDERelated Search:

Trichlorofluoromethane Trifluoromethanesulfonyl chloride TRIFLUOROMETHYLSULPHENYL CHLORIDE Axitinib Carboplatin T0070907 PD 0325901 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)- Crizotinib 3-[3-[N-(2-CHLORO-3-TRIFLUOROMETHYLBENZYL)-(2,2-DIPHENYLETHYL)AMINO]PROPYLOXY]PHENYLACETIC ACID HYDROCHLORIDE

  • 3-[3-[n-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
  • 3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…
  • GW3965 HCl
  • 2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid hydrochloride
  • GW3965 hydrochloride, >=98%
  • Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride
  • GW3965 HCl Salt
  • 3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride
  • CS-742
  • GW 3965 HYDROCHLORIDE; GW-3965 HYDROCHLORIDE;
  • 3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenylacetic Acid Hydrochloride
  • 2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylet...
  • GW-3965 hydrochloride GW3965
  • Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride (1:1)
  • 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-Benzeneacetic acid hydrochloride (1:1)
  • W 3965 HYDROCHLORIDE
  • 405911-17-3
  • C33H31F3ClNO3HCl
  • Inhibitors