REVERSE T3

ChemicalBook > CAS DataBase List > REVERSE T3

Description

Product Name: REVERSE T3
CAS No.: 5817-39-0
Chemical Name: REVERSE T3
Synonyms: T3;TRIIODOTHYRONINE;rT3;LIOTHYRONIN;Reverse triiodothyronine;(2S)-2-aMino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid;L-T3-13C6;REVERSE T3;REVERSE T3;3,3',5'-T3
CBNumber: CB5221268
Molecular Formula: C15H12I3NO4
Formula Weight: 650.97
MOL File: 5817-39-0.mol

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REVERSE T3 Property

Melting point:: 234-238 °C(lit.)
Boiling point:: 534.6±50.0 °C(Predicted)
Density: 2.387±0.06 g/cm3(Predicted)
Flash point:: 9℃
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder
pka: 2.17±0.20(Predicted)
color: Pale Beige to Brown
Stability:: Light Sensitive
InChI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
InChIKey: HZCBWYNLGPIQRK-LBPRGKRZSA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)N

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements: 36-45-36/37-16
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 3
RTECS: AY6750000
F: 8
HS Code: 29379000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T-075
Product name: 3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution
Purity: 100?μg/mL in methanol with 0.1N NH3, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 17598
Product name: 3,3',5'-Triiodo-L-thyronine
Purity: ≥95%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 17598
Product name: 3,3',5'-Triiodo-L-thyronine
Purity: ≥95%
Packaging: 10mg
Price: $162
Updated: 2024/03/01

Cayman Chemical

Product number: 17598
Product name: 3,3',5'-Triiodo-L-thyronine
Purity: ≥95%
Packaging: 25mg
Price: $380
Updated: 2024/03/01

Cayman Chemical

Product number: 17598
Product name: 3,3',5'-Triiodo-L-thyronine
Purity: ≥95%
Packaging: 50mg
Price: $674
Updated: 2024/03/01

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REVERSE T3 Chemical Properties,Usage,Production

Description

Either a derivative or precursor of thyroxine. Triiodothyronine increases themetabolic rate and oxygen consumption of animal tissues. Used in biochemical research, medicine (metabolic insufficiency).

Chemical Properties

Beige Powder

Uses

One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.

Uses

Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.

Definition

ChEBI: 3,3',5'-triiodo-L-thyronine is a 3,3',5'-triiodothyronine. It is a tautomer of a 3,3',5'-triiodo-L-thyronine zwitterion.

Biological Activity

3,3',5'-triiodo-l-thyronine (reverse t3 or rt3) and 3,5,3'-triiodo-l-thyronine (t3) are the metabolism of thyroxine (t4) [1]. 3,3',5'-triiodo-l-thyronine is thyroid hormone receptors trα and trβ antagonist [1].thyroid hormones play important roles in the development of the mammalian brain by acting on migration and differentiation of neural cells, synaptogenesis, and myelination. the actions of thyroid hormones are mediated by nuclear thyroid hormone receptors (trs) and regulation of gene expression. trs have been also involved in adult brain function. in adult mice, trα1 deletion and a dominant negative mutant receptor expression induce consistent behavioral changes leading to severe anxiety and morphological changes in the hippocampus [2].the rt3 was about 1,000-fold less active at the thyroid hormone receptors trα and trβ compared with 3,3',5-triiodo-l-thyronine and commonly described as inactive [1].it has been reported that rt3 activates a native form of trα, trδα1, which lacks a nuclear localization signal and functions in the cytoplasm. through this action, rt3 initiates actin polymerization, particularly in astrocytes and neurons [3].

References

[1] nicod p, burger a, staeheli v, et al. a radioimmunoassay for 3, 3′, 5′-triiodo-l-thyronine in unextracted serum: method and clinical results[j]. the journal of clinical endocrinology & metabolism, 1976, 42(5): 823-829.
[2] bernal j. thyroid hormone receptors in brain development and function[j]. nature clinical practice endocrinology & metabolism, 2007, 3(3): 249-259.
[3] senese r, cioffi f, de lange p, et al. thyroid: biological actions of ‘nonclassical’thyroid hormones[j]. journal of endocrinology, 2014, 221(2): r1-r12.

REVERSE T3 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from REVERSE T3 manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: T3 (Liothyronine sodium) 5817-39-0
Price: US $45.00-35.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 2000kg
Release date: 2024-03-14

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: T3 5817-39-0
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-09-11

Wuhan Quanjinci New Material Co.,Ltd.

Product: T3 5817-39-0
Price: US $45.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000000tons
Release date: 2023-11-01

5817-39-0, REVERSE T3Related Search:

Sodium levothyroxine 3,3',5-Triiodo-L-thyronine Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]- T0901317 T5601640 Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED 4-(4-Hydroxyphenoxy)-3,5-diiodo-benzaldehyde 3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID Levothyroxine EP Impurity B Levothyroxine Impurity 16 N-ForMyl Thyroxine 3,5,3',5'-Tetraiodo Thyroaldehyde Levothyroxine O-Methyl Amine Impurity O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine 3,5-Diiodo-4-(p-Methoxyphenoxy)-benzaldehyde 3,5-Diiodo-L-thyronine 3,3',5-TRIIODOTHYROPROPIONIC ACID 3-IODO-L-TYROSINE

Reverse T3 (3,3',5'-Triiodo-L-Thyronine)

L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-

(2S)-2-aMino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid

REVERSE T3

LIOTHYRONIN

L-3,3',5'-TRIIODOTHYRONINE

3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution

Levothyroxine EP Impurity K

3,3',5'-TRIIODO-L-THYRONINE, THYROID

Reverse L-triiodothyronine

rT3

(S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid

Levothyroxine Impurity 10（Levothyroxine EP Impurity K）

Levothyroxine Impurity K

Reverse T<sub>3</sub>

3,3',5'-triiodo-L-thyronine free acid

Isoliothyronine

3,3’,5-Triiodo-L-thyronine-13C6

3,3’,5-Triiodothyronine-13C6

Liothyronine-13C6

L-T3-13C6

O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine-13C6

T3 (Hormone)-13C6

Tresitope-13C6

Triiodothyronine-13C6

(3,5,3')-TRIIODO-L-THYRONINE

(S)-3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3-iodophenyl]-2-aminopropanoic acid

Reverse triiodothyronine

triiodothyronine,reverse

TRIIODOTHYRONINE

3,3′,5′-Triiodo-L-thyronine 3,3′,5′-Triiodo-L-thyronine

3,3′,5′-Triiodo-L-thyronine thyroid horMone analog

O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-Tyrosine

Levothyroxine EP Imp K

3, 3', 5'- Triiodothyronine (Solution)

Triiodothyronine (L-Liothyronine

Reverse Triiodothyronine hydrochloride (Reverse T3)

(S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyL

REVERSE T3 USP/EP/BP

REVERSE T3

Levothyroxine EP Impurity KQ: What is Levothyroxine EP Impurity K Q: What is the CAS Number of Levothyroxine EP Impurity K Q: What is the storage condition of Levothyroxine EP Impurity K Q: What are the applications of Levothyroxine EP Impurity K

3,3',5'-L-Triiodothyronine

3,3',5'-T3

Alanine,3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]-, L- (8CI)

6-Tetramethyl-4-piperidinone

Triiodothyronine。REVERSE T3

Zebrafish triiodothyronine (T3) ELISA Kit

Levothyroxine Sodium Impurity K

Levothyroxine EP Impurity K (3,3',5'-Triiodo-L-thyronine)

Levothyroxine Sodium EP Impurity K

Liothyronine Triiodothyronin

3, 3', 5'- Triiodothyronine

5817-39-0

472-61-546

C913C6H12I3NO4

BioChemical

Biochemicals and Reagents