ChemicalBook > CAS DataBase List > Liothyronine sodium

Liothyronine sodium

Product Name
Liothyronine sodium
CAS No.
55-06-1
Chemical Name
Liothyronine sodium
Synonyms
Triostat;Liothyronin sodiuM;Ibiot;Cyomel;T3, NA;Cytobin;Cynomel;Cytomine;Sodium T3;Tertroxin
CBNumber
CB3195390
Molecular Formula
C15H11I3NNaO4
Formula Weight
672.96
MOL File
55-06-1.mol
More
Less

Liothyronine sodium Property

Melting point:
205 °C (dec.)(lit.)
alpha 
20 º (c=2,alcohol/1.2N HCl)
RTECS 
YP2836500
storage temp. 
-20°C
solubility 
4 M NH4OH in methanol: 125 g/5mL, clear, yellow-brown
form 
powder
color 
White to Pale Brown
Water Solubility 
Partly miscible in water. Soluble in dimethyl sulfoxide, methanol, sodium hydroxide and ethanol. Practically insoluble in most other organic solvents.
Sensitive 
Light Sensitive
Merck 
5510
BRN 
8179867
InChI
InChI=1/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/s3
InChIKey
SBXXSUDPJJJJLC-ZLBVLXFENA-M
SMILES
C1(C(I)=CC(C[C@H](N)C([O-])=O)=CC=1I)OC1=CC=C(O)C(I)=C1.[Na+] |&1:6,r|
CAS DataBase Reference
55-06-1(CAS DataBase Reference)
EPA Substance Registry System
L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt (55-06-1)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
22-24/25-36
WGK Germany 
3
F 
3-8-10
HS Code 
29379000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

More
Less

N-Bromosuccinimide Price

Alfa Aesar
Product number
J63312
Product name
3,3',5'-Triiodo-L-thyronine sodium salt
Packaging
500mg
Price
$140
Updated
2024/03/01
Alfa Aesar
Product number
J63312
Product name
3,3',5'-Triiodo-L-thyronine sodium salt
Packaging
1g
Price
$215.65
Updated
2024/03/01
Cayman Chemical
Product number
16028
Product name
3,3',5-Triiodo-L-thyronine (sodium salt)
Purity
≥98%
Packaging
1g
Price
$175
Updated
2021/12/16
Cayman Chemical
Product number
16028
Product name
3,3',5-Triiodo-L-thyronine (sodium salt)
Purity
≥98%
Packaging
100mg
Price
$35
Updated
2021/12/16
Sigma-Aldrich
Product number
T6397
Product name
3,3′,5-Triiodo-L-thyronine sodium salt
Purity
powder, BioReagent, suitable for cell culture
Packaging
100mg
Price
$82.2
Updated
2024/03/01
More
Less

Liothyronine sodium Chemical Properties,Usage,Production

Chemical Properties

white to beige powder

Originator

Cytomel,SKF,US,1956

Uses

L-3,3',5-Triiodothyronine, Sodium Salt is shown to stimulate respiratory activity at the mitochondrial level. T3 is a thyroid hormone that increases rates of proteins synthesis, stimulates the breakdown of cholesterol, and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression.

Uses

One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.

Definition

ChEBI: Liothyronine sodium is the sodium salt of liothyronine. Thought to be more active than levothyroxine and with a rapid (few hours) onset and short duration of action, liothyronine sodium is used in the treatment of hypothyroidism, particularly in cases of hypothyroid coma. It contains a 3,3',5-triiodo-L-thyroninate.

Indications

Liothyronine sodium (Cytomel) is the sodium salt of the naturally occurring levorotatory isomer of T3. Liothyronine is generally not used for maintenance thyroid hormone replacement therapy because of its short plasma half-life and duration of action. The use of T3alone is recommended only in special situations, such as in the initial therapy of myxedema and myxedema coma and the short-term suppression of TSH in patients undergoing surgery for thyroid cancer. The use of T3 alone may also be useful in patients with the rare condition of 5'-deiodinase deficiency who cannot convert T4 to T3.

Manufacturing Process

The 3,5-diiodo compound used as a starting material is a known material and may be prepared by the method in British Patents 643,089 and 671,070 and in the Journal of the Chemical Society, London, 1949, page 3424.
Synthesis: L-diiodo thyronine (1.05 g) is dissolved in ammonia (specific gravity 0.880) (40 ml) and methanol (40 ml) and iodinated slowly with shaking with N-iodine in KI solution at room temperature. After iodination,most of the ammonia and methanol are removed by evaporation under diminished pressure, water is added to the original volume, the solution is heated to 60°C and brought to pH 4 with hydrochloric acid. A crystalline precipitate is obtained which after cooling to room temperature is collected and washed with water. At this stage, the crude triiodo thyronine is contaminated with thyroxine and a little unchanged diiodo thyronine.
Purification: The crude precipitate is dissolved in boiling 2N HCl (300 ml) and filtered from the relatively insoluble thyroxine hydrochloride. The hot filtrate is brought to pH 4 with 5N NaOH and triiodo thyronine again separates; after chilling at 0° to 4°C it is collected, washed with water and dried. The yield of triiodo thyronine is 70 to 75% of the theoretical. This triiodo thyronine still contains some thyroxine (about 10%).
The final purification consists of chromatographic separation of thyroxine and triiodo thyronine on a kieselguhr column using 20% chloroform in n-butanol equilibrated with 0.5N NaOH as the developing solvent. 80 to 100 mg triiodo thyronine is purified during each run on a 50 g kieselguhr column. Pure Ltriiodo thyronine has MP 236° to 237°C (dec.) and [α]D29.5° = +21.5 in a 4.75% solution in a mixture of 1 part of N HCl and 2 parts of ethanol. Liothyronine is commonly used as the sodium salt.

brand name

Thyroid hormone Cytomel (King); Triostat (Jones).

General Description

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.

Biochem/physiol Actions

3,3′,5′-Triiodo-L-thyronine (T3) is a thyroid hormone that increases rates of proteins synthesis, stimulates the breakdown of cholesterol, and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

Liothyronine sodium Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Liothyronine sodium Suppliers

Austria 1 Belgium 1 Canada 1 China 237 Europe 2 France 1 Germany 5 India 13 Japan 3 Switzerland 1 United Kingdom 9 United States 33 Global 307
Suzhou Pharmaceutical Technology co.,ltd
Tel
051088771160，18051901298 19952779122
Fax
0510-8877116
Email
2013446823@qq.com
Country
China
ProdList
52
Advantage
61
Shifang ShengYuan Technology Co., Ltd.
Tel
0838-6510595 18881099744 18881099744
Email
1120021438@qq.com
Country
China
ProdList
153
Advantage
56
Shanghai Mokai Pharmaceutical Technology Co., Ltd.
Tel
021-60951261 18601606476
Email
nancy@mkpharma.cn
Country
China
ProdList
453
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Suzhou Ryan Pharmaceutical Technology Co., Ltd.
Tel
0512-68780025,68780026 18962125825
Email
sales@ryanchem.com
Country
China
ProdList
161
Advantage
62
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4550
Advantage
62
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Suzhou Ryan Pharmachem Technology Co.,Ltd
Tel
0512-66585217 13962137180
Fax
0512-82177549
Email
sales@ryanchem.com
Country
China
ProdList
390
Advantage
55
Hubei Datong Bio-Chemical Technology Co.,Ltd
Tel
027-87666700
Fax
027-87666700 skype-lydia0189
Email
xuri@hbdatongchem.com
Country
China
ProdList
147
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
ProdList
1975
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9986
Advantage
55
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3993
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17982
Advantage
56
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9664
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5877
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10287
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
10015
Advantage
53
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Watson Biotechnology Co.,Ltd
Tel
027-027-59207879 18140587686
Fax
QQ：1972026995
Email
kf@3600chem.com
Country
China
ProdList
4699
Advantage
55
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4515
Advantage
55
Struchem Co., Ltd.
Tel
0512-0512-63009836 15365350169
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3989
Advantage
60
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7059
Advantage
55
Hangzhou Dingyan Chem Co., LTD
Tel
0571-0571-87157530-8001-8003 18008611859
Fax
0571-87156470
Email
sales@dingyanchem.com
Country
China
ProdList
1997
Advantage
58
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10457
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3868
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27322
Advantage
60
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1503
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4534
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60
More
Less

View Lastest Price from Liothyronine sodium manufacturers

Wuhan Cell Pharmaceutical Co., Ltd
Product
Liothyronine sodium 55-06-1
Price
US $23.00-19.00/g
Min. Order
10g
Purity
99%
Supply Ability
1000kg
Release date
2023-04-10
Hebei Dangtong Import and export Co LTD
Product
Liothyronine sodium 55-06-1
Price
US $3580.00-3500.00/kg
Min. Order
100kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-06
Henan Fengda Chemical Co., Ltd
Product
Liothyronine sodium 55-06-1
Price
US $8.00-2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-24

55-06-1, Liothyronine sodiumRelated Search:

CHLOROPHOSPHONAZO III 3,3',5-Triiodo-L-thyronine Diclofenac sodium REVERSE T3 TSH Sodium citrate Sodium alginate Sodium iodate Sodium bicarbonate Sodium levothyroxine Sodium periodate Sodium chloride Trisodium phosphate DL-THYROXINE Sodium acetate MCPA SODIUM Sodium benzoate Sodium hydroxide

  • LIOTHYRONINESODIUM,USP
  • 3,3',5-Triiodothyronine sodium salt
  • 3,5,3'-Triiodo-L-thyronine monosodium salt
  • Alanine, 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-, monosodium salt, L- (8CI)
  • Basoprocin
  • Cynomel
  • Cyomel
  • Cytobin
  • Cytomel sodium
  • Cytomine
  • Ibiothyron
  • L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt (9CI)
  • Sodium 3,3',5-triiodo-L-thyronine
  • Sodium 3,5,3'-triiodothyronine
  • Sodium L-3,3',5-triiodothyronine
  • Sodium liothyronine
  • Sodium L-triiodothyronine
  • Sodium T3
  • Sodium triiodo-L-thyronine
  • Sodium triiodothyronine
  • Tertroxin
  • Triiodothyronine sodium salt
  • Triostat
  • llothyronine sodium
  • 3,3,5-TRIIODO-L-THYRONINE SODIUM SALT 98+%
  • 3,3,5-TRIIODO-L -THYRONINE 95-98% SODIUM SALT CRYSTALLINE CELL CULTURE REAGENT
  • 3,3′,5-Triiodo-L-thyronine sodium salt, >=99%
  • 3,3',5-TRIIODO-L-THYRONINE SODIUM*GAMMA- IRRADIATED
  • 3,3',5-TRIIODO-L-THYRONINE SODIUM
  • Liothyronine Sodium USP28
  • L-Triiodothyronine, sodium salt
  • Sodium L-liothyronine
  • Sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
  • Liothyronine, T3, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt
  • L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, monosodium salt
  • 3,3,5-TRIIODO-L -THYRONINE 95-98% SODIUM SALT CRYSTALLINE CELL CULTURE REAGENT GAMMA-IRRADIATED
  • 3,3,5-TRIIODO-L -THYRONINE 95-98% SODIUM SALT CRYSTALLINE
  • T3 Sodium Salt, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine Sodium Salt
  • 3',5-Triiodo-L-thyronine sodium salt
  • L-Triiodothyronine(T3)
  • O-(4-hydroxy-3-iodophenyl)-3,5-diiodo- L-Tyrosine , sodium salt (1:1)
  • (S)-2-AMINO-3-[4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID SODIUM SALT
  • SODIUM (S)-2-AMINO-3-[4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONATE
  • T3 SODIUM SALT
  • T3, NA
  • O-[4-HYDROXY-3-IODOPHENYL]-3,5-DIIODO-L-TYROSINE SODIUM SALT
  • 3,3',5-Triiodo-L-thyronine sodium salt≥ 98% (HPLC)
  • LIOTHYRONINE SODIUM
  • LIOTHYRONINE SODIUM SALT
  • H-THY(3,3',5-I3)-ONA
  • L-3,3',5-TRIIODOTHYRONINE, SODIUM SALT
  • 3,3',5-TRIIODO-L-THYRONINE NA
  • 3,3',5-TRIIODO-L-THYRONINE SODIUM SALT
  • 3,3',5-TRIIODO-L-THYRONINE SODIUM SALT HYDRATE
  • 3,3',5-TRIIODO-L-THYRONINE SODIUM*CELL C ULTURE TEST
  • 3,3',5-Triiodo-L-thyronine, sodium salt,95%
  • T3(3,3',5-Triiodo-L-thyronine)
  • 3,3′,5-Triiodo-L-thyronine sodium salt,Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T3