ChemicalBook > CAS DataBase List > 3,5-Diiodo-L-tyrosine dihydrate

3,5-Diiodo-L-tyrosine dihydrate

Product Name
3,5-Diiodo-L-tyrosine dihydrate
CAS No.
300-39-0
Chemical Name
3,5-Diiodo-L-tyrosine dihydrate
Synonyms
(S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid;diiodotyrosine;L-3,5-DiioDOTyrosine;Liothyronine sodium EP Impurity B;AGONTAN;DITYRIN;3,5-Diiodo-L;L-Diiodotyrosine;H-TYR(3,5-I2)-OH;IODOGORGOIC ACID
CBNumber
CB5490149
Molecular Formula
C9H9I2NO3
Formula Weight
432.98
MOL File
300-39-0.mol
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3,5-Diiodo-L-tyrosine dihydrate Property

Melting point:
200 °C (dec.)(lit.)
alpha 
-20.7 º (c=2.5, 0.1N NaOH/H2O)
Boiling point:
546.5°C (rough estimate)
Density 
2.405±0.06 g/cm3(Predicted)
refractive index 
1.2 ° (C=5, 1mol/L HCl)
storage temp. 
2-8°C
solubility 
Aqueous Acid (Slightly), DMSO (Slightly)
pka
2.12(at 25℃)
form 
crystalline
color 
white
Water Solubility 
slightly soluble
Sensitive 
Light Sensitive
CAS DataBase Reference
300-39-0(CAS DataBase Reference)
NIST Chemistry Reference
3,5-Diiodo-l-tyrosine(300-39-0)
EPA Substance Registry System
L-Tyrosine, 3,5-diiodo- (300-39-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36/37-24/25
RIDADR 
2811
WGK Germany 
3
F 
8
TSCA 
Yes
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H65420
Product name
3,5-Diiodo-L-tyrosine, 95%
Packaging
25g
Price
$66.5
Updated
2021/12/16
Alfa Aesar
Product number
H65420
Product name
3,5-Diiodo-L-tyrosine, 95%
Packaging
100g
Price
$210
Updated
2021/12/16
TRC
Product number
D466055
Product name
3,5-Diiodo-L-tyrosine
Packaging
5g
Price
$85
Updated
2021/12/16
TRC
Product number
D466055
Product name
3,5-Diiodo-L-tyrosine
Packaging
25g
Price
$185
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD46930
Product name
3,5-Diiodo-L-tyrosine
Packaging
500g
Price
$175
Updated
2021/12/16
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3,5-Diiodo-L-tyrosine dihydrate Chemical Properties,Usage,Production

Description

Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity.

Chemical Properties

white to beige powder

Uses

It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity.

Uses

3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity.

Uses

3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist.

Definition

ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.

Synthesis

Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide.

Purification Methods

It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]

3,5-Diiodo-L-tyrosine dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

L-Thyroxine
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3,5-Diiodo-L-tyrosine dihydrate Suppliers

Belgium 2 China 231 Europe 2 Germany 4 India 8 Japan 3 Slovakia 1 Switzerland 5 United Kingdom 11 United States 39 Global 306
Watanabe Chemical Industries, Ltd.
Tel
--
Fax
--
Email
inquiry@watanabechem.co.jp
Country
Japan
ProdList
1918
Advantage
50
Watanabe Chemical Industries, Ltd.
Tel
--
Fax
--
Country
Japan
ProdList
4811
Advantage
42
Nacalai Tesque, Inc.
Tel
--
Fax
--
Email
info-tech@nacalai.co.jp
Country
Japan
ProdList
6046
Advantage
75
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View Lastest Price from 3,5-Diiodo-L-tyrosine dihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
3,5-Diiodo-L-tyrosine dihydrate 300-39-0
Price
US $0.00/Kg/Bag
Min. Order
100g
Purity
98%min
Supply Ability
100kgs
Release date
2021-08-23
Hebei Weibang Biotechnology Co., Ltd
Product
3,5-Diiodo-L-tyrosine dihydrate 300-39-0
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05
Hebei Yanxi Chemical Co., Ltd.
Product
3,5-Diiodo-L-tyrosine dihydrate 300-39-0
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-20

300-39-0, 3,5-Diiodo-L-tyrosine dihydrateRelated Search:

Prostratin, PKC activator H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH L-Alanine Boc-D-Tyr-OH L-Tyrosine 2',6'-Pipecoloxylidide 2-Piperidone 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID 3,4-Dimethoxy-L-phenylalanine L-Thyroxine FMOC-3,5-DIIODO-L-TYROSINE N-Acetyl-3,5-Diiodo-L-tyrosine dihydrate 3 5-DIIODO-L-TYROSINE DIHYDRATE 98%,3 5-DIIODO-L-TYROSINE DIHYDRATE 98 Levothyroxine sodium Sodium levothyroxine Liothyronine sodium 3,3',5-Triiodo-L-thyronine 3,5-Diiodo-L-thyronine

  • 3,5-Diiodo-L-tyrosine dihydrate, BR
  • Liothyronine EP Impurity B
  • 3,5-Diiodo-4-hydroxy-β-phenylalanine
  • 3,5-diiodo-l-tyrosin
  • 3,5-Diiodotyrocine
  • 3,5-Iodo-L-tyrosine
  • 3,5-L-Diiodotyrosine
  • 4-Hydroxy-3,5-diiodophenylalanine
  • diiodotyrosine
  • L-3,5-DiioDOTyrosine
  • Tryosine, 3,5-diiodo-
  • Tyrosine, 3,5-diiodo-, L-
  • L-Diiodotyrosine
  • 3,5-Diiodo-L-tyrosine dihydrate,99%
  • 5-Diiodo-L-tyrosinedehydrate
  • (S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid
  • L-4-hydroxy-3,5-diiodo-phenylalanine
  • DI-IODO-L-TYROSINE(P)
  • 3,5-Diiodo-L-Tyr-OH
  • 3,7-DibroMo-L-Tyrosine
  • 3,5-Diiodo-L-Tyr-OH, 98.5%
  • (2S)-2-amino-3-(4-hydroxy-3,5-diiodo-phenyl)propanoic acid
  • H-Tyr(3,5-Di-I)-OH
  • 3,5-Diiodo-L-tyrosinedehydrate
  • 3,5-DIIODO-4-HYDROXY-BETA-PHENYLALANINE
  • 3,5-DIIODINE-L-TYROSINE
  • 3,5-DIIODO-BETA(4-HYDROXYPHENYL)ALANINE
  • 3,5-DIIODO-TYROSINE
  • 4-HYDROXY-3,5-DIIODOPHENYLALANINE, 2-AMINO-3-(4-HYDROXY-3,5-DIIODOPHENYL)PROPIONIC ACID
  • AGONTAN
  • L-TYROSINE, 3,5-DIIODO-
  • DITYRIN
  • H-TYR(3,5-I2)-OH
  • IODOGORGOIC ACID
  • H-3,5-DIIODO-TYR-OH
  • H-L-TYR(3,5-I2)-OH
  • 3,5-Diiodo-beta-(p-hydroxyphenyl)alanine dihydrate
  • 3,5-Diiodo-L-tyrosine dihydrate
  • H-L-Tyr(3,5-I2)-OH*2H2O
  • 3,5-Diiodo-L
  • -tyrosine dihydrate
  • Levofolinate Impurity 2 (Liothyronine EP Impurity B)
  • 3,5-Diiodo-L-tyrosine dihydrate USP/EP/BP
  • Liothyronine sodium EP Impurity B
  • TIANFU CHEM--3,5-Diiodo-L-tyrosine dihydrate
  • 3,5-Diiodo-L-tyrosine (Liothyronine Impurity)
  • Liothyronine Impurity 2 (Liothyronine EP Impurity B)
  • DIIODO-L-TYROSINE
  • 300-39-0
  • C9H9I2NO3x2H2O
  • C9H9I2NO3
  • C9H912NO3
  • C9H9I2NO32H2O
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • BioChemical
  • Modified Amino Acids
  • A - H