Chemical properties Penetration enhancer Application References
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Laurocapram

Chemical properties Penetration enhancer Application References
Product Name
Laurocapram
CAS No.
59227-89-3
Chemical Name
Laurocapram
Synonyms
AZONE;azon;n-dodecylcaprolactam;n0252;tranzone;NSC11340;usafnd-72;NSC 11340;NSC-11340;USAF NO-72
CBNumber
CB9414646
Molecular Formula
C18H35NO
Formula Weight
281.48
MOL File
59227-89-3.mol
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Laurocapram Property

Melting point:
-7°
Boiling point:
bp50m 160°
Density 
0.906-0.926
refractive index 
1.470-1.473
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka
-0.43±0.20(Predicted)
form 
Oil
color 
Colourless
Merck 
14,5385
LogP
6.570 (est)
CAS DataBase Reference
59227-89-3(CAS DataBase Reference)
EPA Substance Registry System
Laurocapram (59227-89-3)
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Safety

Safety Statements 
24/25
RTECS 
CM3995000
HS Code 
29339900
Hazardous Substances Data
59227-89-3(Hazardous Substances Data)
Toxicity
LD50 rats, mice (g/kg): 8 i.v., i.p. (Stoughton)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
L0317
Product name
Laurocapram
Purity
>96.0%(GC)
Packaging
5mL
Price
$44
Updated
2024/03/01
TCI Chemical
Product number
L0317
Product name
Laurocapram
Purity
>96.0%(GC)
Packaging
25mL
Price
$148
Updated
2024/03/01
TRC
Product number
L185003
Product name
Laurocapram
Packaging
500mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
090554
Product name
N-Dodecylcaprolactam
Purity
95+%
Packaging
1g
Price
$49
Updated
2021/12/16
ApexBio Technology
Product number
C6524
Product name
Laurocapram
Packaging
500mg
Price
$50
Updated
2021/12/16
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Laurocapram Chemical Properties,Usage,Production

Chemical properties

Colorless or slightly yellow transparent liquid, insoluble in water, it can form emulsion with water, soluble in various organic solvents.

Penetration enhancer

Laurocapram, also known as azone, lauric Lun, N-lauryl caprolactam, quinacridone, nitrogen ketone. Its chemical name is 1-n-dodecyl azetidin-2-one, which is a new high security penetration enhancer. It is colorless transparent liquid at room temperature, slightly viscous, odorless. It can form emulsion with water, soluble in various organic solvents, and it has good lubricity, which promote the hydrophilic and lipophilic drug product activity or cosmetics nutrients to penetrate into the skin, greatly reducing the drug remain time in the stratum corneum, significantly enhancing drug efficacy and cosmetic results. Thus, we can reduce the amount of primary medical and reduce costs. Azone transdermal absorption enhancing effect lags behind.
Laurocapram on hydrophilic and lipophilic drugs have significantly transdermal Aided role.  It has good aided effect on many kinds of plant extracts in emulsion state or colloidal state, and alkaloids effect is particularly evident. Transdermal penetration is stronger than dimethyl sulfoxide. 8-bromo cyclic nucleotide containing 1% azone permeability effect is equivalent to 12 times the 50% dimethyl sulfoxide. Often in combination with propylene glycol, synergy, the best use of transdermal concentration of 0.1% to 5%, safe and low toxic, non-irritating. The chemical property is stable, and it is kept up to four years at the room temperature.
It can be considered a decyl methyl sulfoxide with pyrrolidone composite for good novel penetration enhancers, skin irritation. It can promote the drug through the skin barrier corticosteroids, indomethacin, fluorouracil, hydroquinone and many other drugs transdermal absorption, improving local and systemic blood concentration, and improving the bioavailability of the drug. Lipophilic, they have transdermal effect for hydrophilic drugs. It can soften the skin and enhance its permeability. They have anti-inflammatory, analgesic and anti-itching effect. Low toxicity, oral LD50> 7g/kg, it is not compatible with strong acids or Vaseline to avoid reduce the effect.

Application

Laurocapram is used as the penetration enhancer in cosmetic preparations and personal-care products. Laurocapram is combined as an excipient (an inert substance) not an active ingredient. Excipients are added to ensure that the shelf-life of the active ingredients can be long enough to be active until internal use. It can be used as a topical smear, massage penetration enhancers; pesticides, as a pro-absorbing agent and sterilization plant growth regulators, pesticides pro penetration; in addition, can be used for coloring and dyeing leather and other areas of accelerator.

References

http://www.chemicalland21.com/lifescience/foco/LAUROCAPRAM.htm

Uses

antifungal lipopeptide

Uses

Laurocapram is a useful intermediate.

Uses

Pharmaceutic aid (excipient).

Laurocapram Preparation Products And Raw materials

Raw materials

Preparation Products

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Laurocapram Suppliers

TINAMEN
Tel
15607209205
Email
tianmenzhengyi@qq.com
Country
China
ProdList
12
Advantage
58
Jiangxi Xinsen Natural Vegetable Oil Co., Ltd.
Tel
0796-8284836 17379666713
Fax
0796-8284836
Email
592432494@qq.com
Country
China
ProdList
272
Advantage
58
Jiangxi Xuesong Natural Medicinal Oil Co. LTD
Tel
18679669723 18679669723
Email
2134411736@qq.com
Country
China
ProdList
290
Advantage
58
Jiangxi Planty Manor Health Industry Co., Ltd.
Tel
0796-18507969315 18507969315
Email
3686433662@qq.com
Country
China
ProdList
268
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
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View Lastest Price from Laurocapram manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Laurocapram 59227-89-3
Price
US $0.00/KG
Min. Order
25KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-08
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Laurocapram 59227-89-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-21
Hebei Yanxi Chemical Co., Ltd.
Product
Laurocapram 59227-89-3
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-07

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