Chemical properties Penetration enhancer Application References
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Laurocapram

Chemical properties Penetration enhancer Application References
Product Name
Laurocapram
CAS No.
59227-89-3
Chemical Name
Laurocapram
Synonyms
AZONE;azon;n-dodecylcaprolactam;n0252;tranzone;NSC11340;usafnd-72;NSC 11340;NSC-11340;USAF NO-72
CBNumber
CB9414646
Molecular Formula
C18H35NO
Formula Weight
281.48
MOL File
59227-89-3.mol
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Laurocapram Property

Melting point:
-7°
Boiling point:
bp50m 160°
Density 
0.906-0.926
refractive index 
1.470-1.473
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka
-0.43±0.20(Predicted)
form 
Oil
color 
Colourless
Merck 
14,5385
LogP
6.570 (est)
CAS DataBase Reference
59227-89-3(CAS DataBase Reference)
EPA Substance Registry System
Laurocapram (59227-89-3)
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Safety

Safety Statements 
24/25
RTECS 
CM3995000
HS Code 
29339900
Hazardous Substances Data
59227-89-3(Hazardous Substances Data)
Toxicity
LD50 rats, mice (g/kg): 8 i.v., i.p. (Stoughton)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
L0317
Product name
Laurocapram
Purity
>96.0%(GC)
Packaging
5mL
Price
$44
Updated
2024/03/01
TCI Chemical
Product number
L0317
Product name
Laurocapram
Purity
>96.0%(GC)
Packaging
25mL
Price
$148
Updated
2024/03/01
TRC
Product number
L185003
Product name
Laurocapram
Packaging
500mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
090554
Product name
N-Dodecylcaprolactam
Purity
95+%
Packaging
1g
Price
$49
Updated
2021/12/16
ApexBio Technology
Product number
C6524
Product name
Laurocapram
Packaging
500mg
Price
$50
Updated
2021/12/16
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Laurocapram Chemical Properties,Usage,Production

Chemical properties

Colorless or slightly yellow transparent liquid, insoluble in water, it can form emulsion with water, soluble in various organic solvents.

Penetration enhancer

Laurocapram, also known as azone, lauric Lun, N-lauryl caprolactam, quinacridone, nitrogen ketone. Its chemical name is 1-n-dodecyl azetidin-2-one, which is a new high security penetration enhancer. It is colorless transparent liquid at room temperature, slightly viscous, odorless. It can form emulsion with water, soluble in various organic solvents, and it has good lubricity, which promote the hydrophilic and lipophilic drug product activity or cosmetics nutrients to penetrate into the skin, greatly reducing the drug remain time in the stratum corneum, significantly enhancing drug efficacy and cosmetic results. Thus, we can reduce the amount of primary medical and reduce costs. Azone transdermal absorption enhancing effect lags behind.
Laurocapram on hydrophilic and lipophilic drugs have significantly transdermal Aided role.  It has good aided effect on many kinds of plant extracts in emulsion state or colloidal state, and alkaloids effect is particularly evident. Transdermal penetration is stronger than dimethyl sulfoxide. 8-bromo cyclic nucleotide containing 1% azone permeability effect is equivalent to 12 times the 50% dimethyl sulfoxide. Often in combination with propylene glycol, synergy, the best use of transdermal concentration of 0.1% to 5%, safe and low toxic, non-irritating. The chemical property is stable, and it is kept up to four years at the room temperature.
It can be considered a decyl methyl sulfoxide with pyrrolidone composite for good novel penetration enhancers, skin irritation. It can promote the drug through the skin barrier corticosteroids, indomethacin, fluorouracil, hydroquinone and many other drugs transdermal absorption, improving local and systemic blood concentration, and improving the bioavailability of the drug. Lipophilic, they have transdermal effect for hydrophilic drugs. It can soften the skin and enhance its permeability. They have anti-inflammatory, analgesic and anti-itching effect. Low toxicity, oral LD50> 7g/kg, it is not compatible with strong acids or Vaseline to avoid reduce the effect.

Application

Laurocapram is used as the penetration enhancer in cosmetic preparations and personal-care products. Laurocapram is combined as an excipient (an inert substance) not an active ingredient. Excipients are added to ensure that the shelf-life of the active ingredients can be long enough to be active until internal use. It can be used as a topical smear, massage penetration enhancers; pesticides, as a pro-absorbing agent and sterilization plant growth regulators, pesticides pro penetration; in addition, can be used for coloring and dyeing leather and other areas of accelerator.

References

http://www.chemicalland21.com/lifescience/foco/LAUROCAPRAM.htm

Uses

antifungal lipopeptide

Uses

Laurocapram is a useful intermediate.

Uses

Pharmaceutic aid (excipient).

Laurocapram Preparation Products And Raw materials

Raw materials

Caprolactam

Preparation Products

1-Chloro-3-Phenylacetone
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Laurocapram Suppliers

Americas 1 China 495 China Hong Kong 1 Europe 4 Germany 2 India 2 Japan 2 Slovakia 1 South Korea 1 United Kingdom 6 United States 27 Global 542
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View Lastest Price from Laurocapram manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Laurocapram 59227-89-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-21
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Laurocapram 59227-89-3
Price
US $0.00/KG
Min. Order
25KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-08
Baoji Guokang Bio-Technology Co., Ltd.
Product
Laurocapram 59227-89-3
Price
US $46.70/KG
Min. Order
100g
Purity
99%
Supply Ability
10 tons
Release date
2021-06-07

59227-89-3, LaurocapramRelated Search:

Lauric acid Myrcene Laurocapram solution in water LAURETH-4 Lauramidopropyl betaine Sodium lauryl polyoxyethylene ether sulfate potassium dodecyl sulphate Sodium dodecyl sulfate Hexamethylenetetramine Poly(vinyl alcohol) Sodium thiosulfate pentahydrate Magnesium sulfate Ammonium lauryl sulfate MAGNESIUM LAURYL SULFATE Lauryl glucoside LDAO Lauryl betaine POLYETHYLENEGLYCOL 600 MONOOCTYL ETHER

  • n0252
  • acecloguanosine
  • N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone
  • Lauocapram
  • Azone, Laurocapram
  • DODECYLAZACYCLOHEPTAN-2-ONE
  • 1-n-Dodecylazacycloneptan-2-one
  • 1-Dodecylhexahydro-1H-azepine-2-one
  • 4,5,6,7-Tetrahydro-1-dodecyl-1H-azepine-2(3H)-one
  • USAF NO-72
  • 1-dodecylazepan-2-one
  • 1-laurylazepan-2-one
  • hexahydro-n-lauryl-2h-azepin-2-on
  • 1-Dodecyl-2-azepanone
  • DodecylcaprolactaM
  • 1-Dodecylhexahydro-2H-Azepin-2-One (LaurocapraM)
  • LaurocapraM SynonyMs 1-Dodecylhexahydro-2H-azepin-2-one
  • Azone (oil)
  • n-laurylcaprolactam
  • tranzone
  • usafnd-72
  • AZONE
  • azon
  • LAUROCAPRAM
  • 1-DODECYL AZACYCLOHEPTA-2-ONE
  • 1-dodecylazacycloheptan-2-one
  • 1-dodecylhexahydro-2h-azepin-2-one
  • n-dodecylcaprolactam
  • Laurocapra
  • Laurocapramum
  • Laurocapram Laurocapram
  • 2H-Azepin-2-one, 1-dodecylhexahydro-
  • N-Dodecyl-epsilon-caprolactam
  • Laurocapram (water soluble)
  • Laurocapram USP/EP/BP
  • Hot Selling Laurocapram 59227-89-3 with Reasonable Price and Fast Delivery! !
  • NSC 11340
  • NSC11340
  • NSC-11340
  • Laurel azone
  • 59227-89-3
  • C18H35NO
  • Cosmetic
  • Pharmaceutical intermediates, pharmaceutical raw materials
  • ketone
  • 59227-89-3
  • bc0001
  • john's