1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID

Uses

Product Name: 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID
CAS No.: 68947-43-3
Chemical Name: 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID
Synonyms: N-Methylisonipecotic acid;4-Carboxy-1-methylpiperidine;Lasmiditan Impurity 45 Monomer;1-METHYL-PIPERIDIN-4-CARBOXYLIC ACID;N-METHYLPIPERIDINE-4-CARBOXYLIC ACID;N-METHYL-4-PIPERIDINE CARBOXYLIC ACID;1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID;1-methyl-Ppiperidine-4-carboxylic'acid;1-methylpiperidine-4-carboxylic acid(SALTDATA: HCl)
CBNumber: CB1680737
Molecular Formula: C7H13NO2
Formula Weight: 143.18
MOL File: 68947-43-3.mol

More

Less

1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID Property

Boiling point:: 246.1±33.0 °C(Predicted)
Density: 1.103
refractive index: 1.488
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 3.16±0.20(Predicted)
color: Pale yellow
InChI: InChI=1S/C7H13NO2/c1-8-4-2-6(3-5-8)7(9)10/h6H,2-5H2,1H3,(H,9,10)
InChIKey: HCKNAJXCHMACDN-UHFFFAOYSA-N
SMILES: N1(C)CCC(C(O)=O)CC1

More

Less

Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 29333990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: M1930
Product name: 1-Methylpiperidine-4-carboxylic Acid
Purity: min. 98.0 %
Packaging: 5G
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: M1930
Product name: 1-Methylpiperidine-4-carboxylic Acid
Purity: min. 98.0 %
Packaging: 25G
Price: $203
Updated: 2025/07/31

TRC

Product number: M331570
Product name: 1-Methylpiperidine-4-carboxylicAcid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK178041
Product name: 1-Methylpiperidine-4-carboxylicacid
Purity: 98%
Packaging: 5g
Price: $102
Updated: 2021/12/16

Apolloscientific

Product number: OR5738
Product name: 1-Methylpiperidine-4-carboxylicacid
Purity: 97%
Packaging: 25g
Price: $128
Updated: 2021/12/16

More

Less

1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

1-Methylpiperidine-4-carboxylic acid is a heterocyclic organic compound and can be used as a pharmaceutical intermediate.

Chemical Properties

White solid

Synthesis

498-94-2

50-00-0

68947-43-3

Using 4-piperidinecarboxylic acid (1 kg, 7.74 mol) and formaldehyde (37% aqueous solution, 720 g, 8.87 mol, 1.15 eq.) as feedstock, a wet Pd/C catalyst (10%; 55% paste, 100 g) was added to 10 L of water and the mixture was transferred to a stainless steel hydrogenation reactor. The reactor was pressurized with hydrogen (3 bar) and the reaction mixture was reacted overnight at 16-25 °C with a stirring speed of 200-2500 rpm. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was washed with 500 mL of water and subsequently concentrated under vacuum. The residue was azeotropically distilled by ethanol (2 x 1 L) to remove residual water. Finally, the resulting solid was dried under vacuum at 50 °C overnight to afford 1-methylpiperidine-4-carboxylic acid as an off-white solid (1087 g, 98.1% yield).

References

[1] Patent: WO2003/84949, 2003, A1. Location in patent: Page/Page column 45; 46
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10118 - 10129
[3] Patent: US6777428, 2004, B1. Location in patent: Page column 24
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 4, p. 449 - 459
[5] Patent: WO2008/62182, 2008, A1. Location in patent: Page/Page column 161-162

1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Ethanol Formaldehyde Palladium Ethyl acetate Isonipecotic acid

Preparation Products

More

Less

1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID Suppliers

China 154 Germany 3 India 7 Switzerland 1 Ukraine 1 United Kingdom 4 United States 18 Global 188

Suzhou HaoYue Biological Technology Co., Ltd.

Tel: 15370097289
Email: sales@szhaoyue.com.cn
Country: China
ProdList: 9
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Shangchem Co., Ltd.

Tel: +86-21-68182121
Fax: +86-21-68182121
Country: China
ProdList: 882
Advantage: 52

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

More

Less

View Lastest Price from 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID manufacturers

Henan Bao Enluo International TradeCo.，LTD

Product: 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID 68947-43-3
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-06-26

Xingtai Haoxun Import and Export Trade Co., Ltd.

Product: 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID 68947-43-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2020-07-16

Shijiazhuang Erche Biotechnology Co., Ltd

Product: 1-Methylpiperidine-4-carboxylic Acid 68947-43-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: ≥99%
Supply Ability: 10000kg
Release date: 2021-06-22

68947-43-3, 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACIDRelated Search:

1-Acetyl-4-piperidinecarboxylic acid 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER N-BOC-ISONIPECOTIC ACID Ethyl 4-(ethoxycarbonyl)piperidine-1-acetate DIPHENOXYLATE HYDROCHLORIDE 1-BENZYL-3-OXO-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER Ethyl 1-benzylpiperidine-4-carboxylate Diphenoxylate MEPERIDINE 4-Anilino-1-benzyl-4-piperidinecarboxylic acid Ethyl N-benzyl-3-oxo-4-piperidine-carboxylate hydrochloride 1-METHYL-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER 1-N-Boc-4-methyl-piperidine-4-carboxylic acid 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Boc-4-(Hydroxymethyl)-4-methyl-piperidine 1-METHYL-PIPERIDINE-2-CARBOXYLIC ACID HCL 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID X HCL,1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID HCL N-Boc-piperidine-3-methanol

1-methylpiperidine-4-carboxylic acid(SALTDATA: HCl)

4-Carboxy-1-methylpiperidine

1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID

N-METHYL-4-PIPERIDINE CARBOXYLIC ACID

N-METHYLPIPERIDINE-4-CARBOXYLIC ACID

1-METHYL-PIPERIDIN-4-CARBOXYLIC ACID

1-methyl-Ppiperidine-4-carboxylic'acid

N-Methylisonipecotic acid

Lasmiditan Impurity 45 Monomer

68947-43-3

68437-43-3

Carboxylic Acids

Pyrans, Piperidines & Piperazines

Piperidine