1-Boc-4-methylpiperidine-4-carboxylic acid

Product Name: 1-Boc-4-methylpiperidine-4-carboxylic acid
CAS No.: 189321-63-9
Chemical Name: 1-Boc-4-methylpiperidine-4-carboxylic acid
Synonyms: 1-Boc-4-MethyL;CHEMBRDG-BB 4002933;-4-piperidinecarboxyL;N-BOC-4-METHYL ISONIPECOTIC ACID;1-BOC-4-METHYL-ISONIPECOTIC ACID;4-METHYL-4-CARBOXY-1-N-BOC-PIPERIDINE;N-BOC-4-METHYL-4-PIPERIDINECARBOXYLIC ACID;1-Boc-4-methyl-4-piperidinecarboxylic Acid;1-BOC-4-Methyl-piperidin-4-carboxylic acid;1-BOC-4-METHYL-PIPERIDINE-4-CARBOXYLIC ACID
CBNumber: CB4192851
Molecular Formula: C12H21NO4
Formula Weight: 243.3
MOL File: 189321-63-9.mol

More

Less

1-Boc-4-methylpiperidine-4-carboxylic acid Property

Boiling point:: 354.3±35.0 °C(Predicted)
Density: 1.129±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.69±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C12H21NO4/c1-11(2,3)17-10(16)13-7-5-12(4,6-8-13)9(14)15/h5-8H2,1-4H3,(H,14,15)
InChIKey: OKBNEDPOUYRYNP-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C)(C(O)=O)CC1
CAS DataBase Reference: 189321-63-9(CAS DataBase Reference)

More

Less

Safety

RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B6385
Product name: 1-(tert-Butoxycarbonyl)-4-methylpiperidine-4-carboxylic Acid
Purity: min. 98.0 %
Packaging: 1G
Price: $49
Updated: 2025/07/31

TCI Chemical

Product number: B6385
Product name: 1-(tert-Butoxycarbonyl)-4-methylpiperidine-4-carboxylic Acid
Purity: min. 98.0 %
Packaging: 5G
Price: $145
Updated: 2025/07/31

TRC

Product number: B699548
Product name: 1-(tert-Butoxycarbonyl)-4-methylpiperidine-4-carboxylicAcid
Packaging: 2.5mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B699548
Product name: 1-(tert-Butoxycarbonyl)-4-methylpiperidine-4-carboxylicAcid
Packaging: 5mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB123231
Product name: 1-(tert-Butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid
Packaging: 250mg
Price: $57.5
Updated: 2021/12/16

More

Less

1-Boc-4-methylpiperidine-4-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to Light yellow powder to crystal

Synthesis

A mixture of Ethyl N-Boc-4-methylpiperidine-4-carboxylate (4.1 g, 15.1mmol) and lithium hydroxide (2.17g, 90.6mmol) in methanol (3OmL)ZH2O (2OmL) was stirred at a temperature of about 25 ℃ for 16h. After evaporation to dryness, the residue was partitioned between DCM and brine. The organic layer was separated, dried (MgSO4), filtered, and concentrated under reduced pressure to provide 3.38g of 1-Boc-4-methylpiperidine-4-carboxylic acid as a white solid (yield 92.0 percent).

References

[1] Patent: WO2008/89201, 2008, A2. Location in patent: Page/Page column 234
[2] Patent: US2010/137305, 2010, A1. Location in patent: Page/Page column 36
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 14, p. 3675 - 3678
[4] Patent: US6083949, 2000, A
[5] Patent: EP854870, 2009, B1. Location in patent: Page/Page column 42

1-Boc-4-methylpiperidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Ethanol Di-tert-butyl dicarbonate Diisopropylamine Lithium hydroxide monohydrate Tetrahydrofuran Ammonium chloride Ethyl 4-piperidinecarboxylate Ethyl acetate Hydrochloric acid Dichloromethane Methanol PETROLEUM ETHER Iodomethane n-Butyllithium

Preparation Products

More

Less

1-Boc-4-methylpiperidine-4-carboxylic acid Suppliers

China 137 Germany 1 India 1 United Kingdom 4 United States 20 Global 163

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

ITIC MEDCHEM(SUZHOU) CO.,LTD.

Tel: 0512-68323967 18015559028
Fax: +86-512-69200360
Email: sales@iticmedchem.com
Country: China
ProdList: 506
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.

Tel: 21-54820552 18964669552
Fax: 086-21-64964478
Email: 188738128@qq.com
Country: China
ProdList: 310
Advantage: 66

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

More

Less

View Lastest Price from 1-Boc-4-methylpiperidine-4-carboxylic acid manufacturers

Career Henan Chemical Co

Product: 1-Boc-4-methylpiperidine-4-carboxylic acid 189321-63-9
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customise
Release date: 2018-08-09

189321-63-9, 1-Boc-4-methylpiperidine-4-carboxylic acidRelated Search:

o-Toluic acid p-Toluic acid Triacetonediamine 2,2,6,6-Tetramethyl-4-piperidinol tert-Butyl carbazate 1,2,2,6,6-Pentamethyl-4-piperidinol Isonipecotic acid BOC-4-PHENYLPIPERIDINE-4-CARBOXYLIC ACID 1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID Ethyl N-Boc-4-methylpiperidine-4-carboxylate N-Boc-3-Methylnipecotic acid ethyl ester 1-N-Boc-3-Methylpiperidine-3-carboxylic acid BOC-4-CYCLOHEXYL-PIPERIDINE-4-CARBOXYLIC ACID N-BOC-4-(P-FLUOROPHENYL)-4-PIPERIDINECARBOXYLIC ACID 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester METHYL 4-AMINOMETHYL-1-BOC-PIPERIDINE-4-CARBOXYLATE N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID N-BOC-4-(P-CHLOROPHENYL)-4-PIPERIDINE CARBOXYLIC ACID

N-BOC-4-METHYL ISONIPECOTIC ACID

N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLIC ACID

N-BOC-4-METHYL-4-PIPERIDINECARBOXYLIC ACID

CHEMBRDG-BB 4002933

4-METHYL-4-CARBOXY-1-N-BOC-PIPERIDINE

4-METHYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

1-BOC-4-METHYL-PIPERIDINE-4-CARBOXYLIC ACID

1-Boc-4-methyl-4-piperidinecarboxylic Acid

1-(tert-Butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid

N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLIC ACIDN-BOC-4-METHYL ISONIPECOTIC ACID

1-N-Boc-4-methyl-piperidine-4-carboxylic acid

1-BOC-4-METHYL-ISONIPECOTIC ACID

1,4-Piperidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethylethyl) ester

1,4-piperidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethy

1-Boc-4-methyl-piperidine-4-carboxylic acid ,98%

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid(SALTDATA: FREE)

N-Boc-4-Methyl-piperidine-4-carboxylic acid/

1-tert-butoxycarbonyl-4-methyl-isonipecotic acid

4-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid

1-(tert-butoxy-oxomethyl)-4-methyl-4-piperidinecarboxylic acid

1-Boc-4-MethyL

-4-piperidinecarboxyL

4-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylicaci

1-Boc-4-methylpiperidine-4-carboxylic acid USP/EP/BP

1,4-Piperidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethylethyl) ester (9CI, ACI)

4-methyl-1,4-Piperidinedicarboxylic acid 1-(1,1-dimethylethyl) ester (9CI ACI)

1-Boc-4-methyl-isonipecotic acid, CAS 189321-63-9

1-BOC-4-Methyl-piperidin-4-carboxylic acid

189321-63-9

API intermediates

Amino Acids and Derivatives

Heterocycles

Pyridines