Ethyl N-Boc-4-methylpiperidine-4-carboxylate

Product Name: Ethyl N-Boc-4-methylpiperidine-4-carboxylate
CAS No.: 189442-87-3
Chemical Name: Ethyl N-Boc-4-methylpiperidine-4-carboxylate
Synonyms: ETHYL N-BOC-4-METHYLPIPERIDINE-4-CARBOX&;N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLATE;N-BOC-4-METHYL ISONIPECOTIC ACID ETHYL ESTER;Ethyl 1-Boc-4-methylpiperidine-4-carboxylate;ETHYL N-BOC-4-METHYLPIPERIDINE-4-CARBOXYLATE;1-Boc-4-Methyl-isonipecotic acid ethyl ester;ETHYL 1-N-BOC-4-METHYL-PIPERIDINE-CARBOXYLATE;Ethyl N-Boc-4-methylpiperidine-4-carboxylate ,97%;N-Boc-4-Methyl isonipecotic acid ethyl ester ,95%;1,4-PIPERIDINEDICARBOXYLIC ACID, 4-1-(1,1-DIMETHYL
CBNumber: CB7133477
Molecular Formula: C14H25NO4
Formula Weight: 271.35
MOL File: 189442-87-3.mol

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Ethyl N-Boc-4-methylpiperidine-4-carboxylate Property

Boiling point:: 329.7±35.0 °C(Predicted)
Density: 1.0134 g/mL at 25 °C
refractive index: 1.4554
Flash point:: 110 °C
storage temp.: 2-8°C
pka: -2.20±0.40(Predicted)
Appearance: Colorless to light yellow Liquid

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Safety

Hazard Codes: T
Risk Statements: 25-37/38-41
Safety Statements: 26-36/37/39-45
RIDADR: UN 2810
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 673927
Product name: Ethyl N-Boc-4-methylpiperidine-4-carboxylate
Purity: 97%
Packaging: 1g
Price: $143
Updated: 2023/06/20

TRC

Product number: E932508
Product name: Ethyl N-Boc-4-methylpiperidine-4-carboxylate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: 9873AA
Product name: 1-tert-Butyl4-ethyl4-methylpiperidine-1,4-dicarboxylate
Packaging: 1g
Price: $87
Updated: 2021/12/16

Matrix Scientific

Product number: 123991
Product name: Ethyl1-Boc-4-methylpiperidine-4-carboxylate
Purity: 95+%
Packaging: 1g
Price: $116
Updated: 2021/12/16

AK Scientific

Product number: 9873AA
Product name: 1-tert-Butyl4-ethyl4-methylpiperidine-1,4-dicarboxylate
Packaging: 5g
Price: $154
Updated: 2021/12/16

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Ethyl N-Boc-4-methylpiperidine-4-carboxylate Chemical Properties,Usage,Production

Uses

Reactant for synthesis of:

Dipeptidyl peptidase-4 inhibitor ABT-279
Building blocks for piperazine-based CCR5 antagonists

Synthesis

142851-03-4

74-88-4

189442-87-3

Ethyl N-Boc-4-piperidinecarboxylate (10.00 g, 36.92 mmol) was dissolved in tetrahydrofuran (THF, 100 mL) and the solution was cooled to -78 °C. Under nitrogen protection, lithium diisopropylammonium (LDA, 47 mmol, 23 mL) was slowly added, maintaining the temperature at -78 °C, and the reaction mixture was stirred for 1 hour. Subsequently, iodomethane (81.25 mmol, 5.08 mL) was added dropwise and stirring was continued at -78 °C for 1 hour. Upon completion of the reaction, the cold bath was removed and the reaction mixture was allowed to warm slowly to room temperature and stirring was continued for 30 min. The reaction was quenched with saturated ammonium chloride (NH4Cl) solution followed by partition extraction with ethyl acetate (EtOAc). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target product ethyl N-Boc-4-methyl-4-piperidinecarboxylate in quantitative yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6) with chemical shifts δ: 4.11 (q, J=7.1 Hz, 2H), 3.61 (dt, J=13.4 Hz, J=4.5 Hz, 2H), 2.95 (d, J=0.3 Hz, 2H), 1.91 (d, J=13.6 Hz, 2H), 1.39 (s, 9H) , 1.31 (m, 2H), 1.19 (m, 3H), 1.15 (s, 3H).

References

[1] Patent: WO2015/86527, 2015, A1. Location in patent: Page/Page column 113; 114
[2] Patent: WO2015/86525, 2015, A1. Location in patent: Page/Page column 117
[3] Patent: WO2008/121687, 2008, A2. Location in patent: Page/Page column 43; 89; 94
[4] Patent: WO2006/83003, 2006, A1. Location in patent: Page/Page column 36-37
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 11, p. 4680 - 4692

Ethyl N-Boc-4-methylpiperidine-4-carboxylate Preparation Products And Raw materials

Raw materials

Ethanol Sodium sulfate Di-tert-butyl dicarbonate Triethylamine Diisopropylamine Tetrahydrofuran Ammonium chloride Ethyl 4-piperidinecarboxylate Ethyl acetate Hydrochloric acid Sodium bicarbonate Dichloromethane Methanol Magnesium sulfate PETROLEUM ETHER Iodomethane Potassium bisulfate n-Butyllithium

Preparation Products

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Ethyl N-Boc-4-methylpiperidine-4-carboxylate Suppliers

China 96 India 2 Switzerland 1 United States 12 Global 111

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View Lastest Price from Ethyl N-Boc-4-methylpiperidine-4-carboxylate manufacturers

Career Henan Chemical Co

Product: Ethyl N-Boc-4-methylpiperidine-4-carboxylate 189442-87-3
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%； 99%
Supply Ability: 1kg; 5kg; 10kg；25kg
Release date: 2020-01-07

189442-87-3, Ethyl N-Boc-4-methylpiperidine-4-carboxylateRelated Search:

Triacetonediamine Ethyl acetate Urethane 1,2,2,6,6-Pentamethyl-4-piperidinol tert-Butyl carbazate Ethylparaben Ethanol Ethyl cyanoacetate Ethyl acrylate Ethyl 4-piperidinecarboxylate RESMETHRIN ISOXADIFEN-ETHYL Ethyl pyruvate 2,2,6,6-Tetramethyl-4-piperidinol Ethyl formate 4-(N-Boc-amino)phenylboronic acid pinacol ester Ethyl chloroformate 4-Methylpiperidine

ETHYL N-BOC-4-METHYLPIPERIDINE-4-CARBOX&

1,4-PIPERIDINEDICARBOXYLIC ACID, 4-1-(1,1-DIMETHYL

1-TERT-BUTYL 4-METHYL 4- METHYLPIPERIDINE1,4-DICARBOXYLATE

N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLATEN-BOC-4-METHYL ISONIPECOTIC ACID ETHYL ESTER

N-Boc-4-Methyl isonipecotic acid ethyl ester ,95%

Ethyl N-Boc-4-methylpiperidine-4-carboxylate ,97%

1-tert-Butoxycarbonyl-4-methylpiperidine-4-carboxylic acid ethyl ester

4-Methyl-1,4-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 4-ethyl ester

Ethyl 1-Boc-4-methylpiperidine-4-carboxylate

N-BOC-4-METHYL ISONIPECOTIC ACID ETHYL ESTER

N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLATE

ETHYL 1-N-BOC-4-METHYL-PIPERIDINE-CARBOXYLATE

ETHYL N-BOC-4-METHYLPIPERIDINE-4-CARBOXYLATE

1-O-TERT-BUTYL 4-O-ETHYL 4-METHYLPIPERIDINE-1,4-DICARBOXYLATE

1-tert-butyl 4-ethyl 4-Methylpiperidine-1,4-dicarboxylate

1-Boc-4-Methyl-isonipecotic acid ethyl ester

1,4-Piperidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethylethyl) 4-ethyl ester

Ethyl N-Boc-4-methylpiperidine-4-carboxylate USP/EP/BP

Ethyl <i>N</i>-Boc-4-methylpiperidine-4-carboxylate

Ethyl 1-Boc-4-methylpiperidine-4-carboxylate - [E14287]

189442-87-3

189-35-2

Piperidines

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Building Blocks

Heterocyclic Building Blocks

Piperidines

Heterocycles

API intermediates

Amino Acids and Derivatives