1,2,2,6,6-Pentamethyl-4-piperidinol
- Product Name
- 1,2,2,6,6-Pentamethyl-4-piperidinol
- CAS No.
- 2403-89-6
- Chemical Name
- 1,2,2,6,6-Pentamethyl-4-piperidinol
- Synonyms
- HOPEMP;NSC 364075;METHYL-TAA-OL;Pentamethylpyridinol;Pentamethylpiperidinol;5-MethylpiperidineAlcohol;1,2,2,6,6-Pentamethyl-4-piperi;N-Methyltriacetoneaminoalcohol;N-METHYL-TRIACETONAMINO ALCOHOL;1,2,2,6,6-pentamethylpiperidinol
- CBNumber
- CB6457693
- Molecular Formula
- C10H21NO
- Formula Weight
- 171.28
- MOL File
- 2403-89-6.mol
1,2,2,6,6-Pentamethyl-4-piperidinol Property
- Melting point:
- 72-76 °C
- Boiling point:
- 238 °C
- Density
- 0.967
- vapor pressure
- 0.845Pa at 25℃
- refractive index
- 1.4621 (estimate)
- Flash point:
- 118 °C
- storage temp.
- Sealed in dry,Room Temperature
- form
- Flakes
- pka
- 14.93±0.60(Predicted)
- color
- Light yellow
- Water Solubility
- 4.8 g/100 mL (20 ºc)
- BRN
- 1498
- InChI
- 1S/C10H21NO/c1-9(2)6-8(12)7-10(3,4)11(9)5/h8,12H,6-7H2,1-5H3
- InChIKey
- NWHNXXMYEICZAT-UHFFFAOYSA-N
- SMILES
- CN1C(C)(C)CC(O)CC1(C)C
- LogP
- 1.15 at 25℃
- CAS DataBase Reference
- 2403-89-6(CAS DataBase Reference)
- EPA Substance Registry System
- 4-Piperidinol, 1,2,2,6,6-pentamethyl- (2403-89-6)
Safety
- Hazard Codes
- Xi,C,N,Xn
- Risk Statements
- 43-34-22-51/53
- Safety Statements
- 36/37-45-36/37/39-26-61
- RIDADR
- UN3261 - class 8 - PG 1 - EHS - Corrosive solid, acidic, organic, n.o.s., HI: all
- WGK Germany
- 2
- TSCA
- TSCA listed
- HS Code
- 29333990
- Storage Class
- 8A - Combustible corrosive hazardous materials
- Hazard Classifications
- Acute Tox. 4 Oral
Aquatic Chronic 2
Skin Corr. 1A
Skin Sens. 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H1068
- Product name
- 4-Hydroxy-1,2,2,6,6-pentamethylpiperidine
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $166
- Updated
- 2025/07/31
- Product number
- H1068
- Product name
- 4-Hydroxy-1,2,2,6,6-pentamethylpiperidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- P271790
- Product name
- 1,2,2,6,6-Pentamethyl-4-piperidinol
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- JK566694
- Product name
- 1,2,2,6,6-Pentamethyl-4-piperidinol
- Purity
- 99%
- Packaging
- 25g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- F523
- Product name
- 1,2,2,6,6-Pentamethyl-4-piperidinol
- Packaging
- 25g
- Price
- $20
- Updated
- 2021/12/16
1,2,2,6,6-Pentamethyl-4-piperidinol Chemical Properties,Usage,Production
Chemical Properties
LIGHT YELLOW FLAKES
Uses
Reactant for: Synthesis of photostable blue emitting naphthalimides1 Synthesis of blue fluorescent naphthalimide pH chemosensors2 Synthesis of crowded piperidines with intramolecularly hydrogen-bonded nitrogen3 Synthesis of spiropyrans and spirooxazines4 Amine photoredox reactions5
Uses
Reactant for:
Synthesis of photostable blue emitting naphthalimides
Synthesis of blue fluorescent naphthalimide pH chemosensors
Synthesis of crowded piperidines with intramolecularly hydrogen-bonded nitrogen
Synthesis of spiropyrans and spirooxazines
Amine photoredox reactions
Uses
1,2,2,6,6-Pentamethyl-4-piperidinol is used in the synthesis of PDGFR kinase inhibitors. Also, it can be applied to the preparation of a new diol-functionalized amine light stabilizer.
Flammability and Explosibility
Non flammable
Synthesis
1,2,2,6,6-pentamethylpiperidinol was synthesized by reductive methylation reaction using 2,2,6,6-tetramethylpiperidinol, paraformaldehyde and formic acid as the raw materials and water as the solvent, and the structure of the product was characterized by nuclear magnetic resonance (NMR) hydrogen spectroscopy, carbon spectroscopy and infrared spectroscopy. The results of one-way and orthogonal experiments showed that the molar ratio of raw materials had the greatest influence on the reductive methylation reaction, followed by the reaction temperature and finally the reaction time. The suitable conditions for this reductive methylation reaction were: n (tetramethylpiperidinol): n (paraformaldehyde): n (formic acid) = 1:1.05:1.05, reaction temperature of 80 ??C, reaction time of 2.5 h, and the solvent water could be applied three times. Under this optimized condition, the average yield of pentamethylpiperidinol was 97.9% and the purity was 99.6%.
Toxics Screening Level
The initial threshold screening level (ITSL) for 1,2,2,6,6-pentamethyl-4-piperidinol is 0.1 μg/m3 based on annual averaging time.
1,2,2,6,6-Pentamethyl-4-piperidinol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,2,2,6,6-Pentamethyl-4-piperidinol manufacturers
- Product
- 1,2,2,6,6-Pentamethyl-4-piperidinol 2403-89-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-08-21
- Product
- 1,2,2,6,6-Pentamethyl-4-piperidinol 2403-89-6
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2025-06-13
- Product
- 1,2,2,6,6-Pentamethyl-4-piperidinol 2403-89-6
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-08