ChemicalBook > CAS DataBase List > 2,2,6,6-Tetramethylpiperidine

2,2,6,6-Tetramethylpiperidine

Product Name
2,2,6,6-Tetramethylpiperidine
CAS No.
768-66-1
Chemical Name
2,2,6,6-Tetramethylpiperidine
Synonyms
HTMP;TETRAMETHYLPIPERIDINE;2,2,6,6-TetramethyL;6-TetraMethylpiperidine;2,2,6,6-Teteamethyl-piperidine;2,2,6,6-Tetramethylpiperidine(Tmp);2,2,6;Norpempidine;2,2,6,6-Tetramethylp;2,2,6,6-tetramethyl-piperidin
CBNumber
CB3320372
Molecular Formula
C9H19N
Formula Weight
141.25
MOL File
768-66-1.mol
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2,2,6,6-Tetramethylpiperidine Property

Melting point:
-59°C
Boiling point:
152 °C (lit.)
Density 
0.837 g/mL at 25 °C (lit.)
vapor pressure 
14 hPa (39 °C)
refractive index 
n20/D 1.445(lit.)
Flash point:
76 °F
storage temp. 
Store below +30°C.
solubility 
MISCIBLE
pka
11.07(at 25℃)
form 
Liquid
Specific Gravity
0.837
color 
Clear colorless to yellow
Water Solubility 
MISCIBLE
Sensitive 
Air Sensitive
BRN 
103296
InChIKey
RKMGAJGJIURJSJ-UHFFFAOYSA-N
CAS DataBase Reference
768-66-1(CAS DataBase Reference)
NIST Chemistry Reference
Piperidine, 2,2,6,6-tetramethyl-(768-66-1)
EPA Substance Registry System
Piperidine, 2,2,6,6-tetramethyl- (768-66-1)
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Safety

Hazard Codes 
Xn,F,C
Risk Statements 
10-22-36/37/38
Safety Statements 
26-37/39-16
RIDADR 
UN 1992 3/PG 3
WGK Germany 
2
RTECS 
TN4220000
Autoignition Temperature
290 °C
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29333999
Toxicity
LD50 orally in Rabbit: 500 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H290May be corrosive to metals

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.18132
Product name
2,2,6,6-Tetramethylpiperidine
Purity
for synthesis
Packaging
25mL
Price
$114
Updated
2024/03/01
Sigma-Aldrich
Product number
115754
Product name
2,2,6,6-Tetramethylpiperidine
Purity
≥99%
Packaging
5g
Price
$44.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18132
Product name
2,2,6,6-Tetramethylpiperidine
Purity
for synthesis
Packaging
100mL
Price
$205
Updated
2024/03/01
Sigma-Aldrich
Product number
115754
Product name
2,2,6,6-Tetramethylpiperidine
Purity
≥99%
Packaging
10g
Price
$84
Updated
2024/03/01
TCI Chemical
Product number
T1051
Product name
2,2,6,6-Tetramethylpiperidine
Purity
>98.0%(GC)(T)
Packaging
25mL
Price
$113
Updated
2024/03/01
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2,2,6,6-Tetramethylpiperidine Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow-green liquid

Uses

2,2,6,6-Tetramethylpiperidine is a hindered base used to prepare metallo-amide bases and selective generation of silylketene acetals. It is used in the preparation of hibarimicinone, (Z)-silylketene acetal and 4-substituted quinazoline. It acts as a precursor to Lithium tetramethylpiperidide and (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl radical.

Uses

2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.

Uses

The lithium amide has been used to efficiently ortho deprotonate pyridine-3-carboxamides.

Preparation

Many routes for the synthesis of TMP have been reported. One method starts with a conjugate addition reaction of ammonia to phorone. The intermediate triacetone amine is then reduced in a Wolff-Kishner reaction.

2,2,6,6-Tetramethylpiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

2-METHOXY-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 5-FLUORO-2-PICOLINIC ACID 5-FORMYL-2,4-DIMETHOXYPYRIMIDINE 3-BROMO-2-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE (E)-5-(2-CARBOXYVINYL)-2,4-DIMETHOXYPYRIMIDINE 3-CYANOPYRIDIN-4-YLBORONIC ACID 5-(TRIFLUOROMETHYL)-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2-CHLORO-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2-CYANOPYRIDIN-3-YLBORONIC ACID 3-METHOXY-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 4-(TRIFLUOROMETHYL)-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2,2,6,6-Tetramethylpiperidinooxy 6-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID 2-(TRIFLUOROMETHYL)-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2-CYANO-5-BROMOPHENYLBORONIC ACID PINACOL ESTER 2-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID 4-CYANOPYRIDIN-3-YLBORONIC ACID 2-BROMO-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 4-CHLORO-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2-(TRIFLUOROMETHYL)-4-ISOCYANATOPYRIDINE 3-FLUORO-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE
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2,2,6,6-Tetramethylpiperidine Suppliers

Belgium 2 Canada 2 China 344 Czech Republic 1 Europe 2 France 1 Germany 10 India 13 Italy 1 Japan 7 Poland 2 Slovakia 2 South Korea 2 Switzerland 4 Ukraine 1 United Kingdom 23 United States 49 Global 466
Nanjing Hike Biological Technology.,ltd
Tel
025-52110956 17372769668
Email
lvmu@lskhsw.com
Country
China
ProdList
30
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Wuhan EnTai Technology Development Co,.Ltd
Tel
86-27-82330560
Fax
86-27-82330547
Email
2536851935@qq.com
Country
China
ProdList
348
Advantage
69
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
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INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
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84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2341
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56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
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81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
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View Lastest Price from 2,2,6,6-Tetramethylpiperidine manufacturers

Hebei Guanlang Biotechnology Co,.LTD
Product
2,2,6,6-Tetramethylpiperidine 768-66-1
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2023-03-29
Henan Aochuang Chemical Co.,Ltd.
Product
2,2,6,6-Tetramethylpiperidine 768-66-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Hebei Zhanyao Biotechnology Co. Ltd
Product
2,2,6,6-Tetramethylpiperidine 768-66-1
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-17

768-66-1, 2,2,6,6-TetramethylpiperidineRelated Search:

2,6-Lutidine 4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE PURUM 97%,4-Amine-2,2,6,6-Tetramethylpiperidine DROPERIDOL Haloperidol 2,2,6,6-Tetramethylpiperidinooxy 2,2,6,6-Tetramethyl-4-piperidinol Triacetonamine Diphenoxylate PHENCYCLIDINE-D5 HYDROCHLORIDE 4-Oxo-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical 4-Amino-TEMPO, free radical 2,2,6,6-Tetramethyl-4-piperidone hydrochloride 3,5-Dibromo-4-oxo-2,2,6,6-tetramethylpiperidin-1-yl 1,2,2,6,6-PENTAMETHYLPIPERIDINE 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical,4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl, TEMPOL Light Stabilizer 770 Light Stabilizer-944 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical [Catalyst for Oxidation],4-Acetamido-2,2,6,6-tetramethylpiperidine N-oxyl

  • HTMP
  • 2,2,6,6-TETRAMETHYLPIPERIDINE
  • 2,2,6,6-TetramethyL
  • 2,2,6,6-Teteamethyl-piperidine
  • 2,2,6,6-Tetramethylpiperidine(Tmp)
  • 2,2,6,6-tetramethyl-piperidin
  • Norpempidine
  • 2,2,6,6-Tetramethylpiperidine (HTMP)
  • 2,2,6,6-Tetramethylpiperidine, 98+%
  • 2,2,6,6-TETRAMETHYLPIPERIDINE, 99+%
  • 2,2,6,6-Tetramethylpiperidien
  • TETRAMETHYLPIPERIDINE
  • Piperidine, 2,2,6,6-tetramethyl-
  • 2,2,6,6-tetramethylpiperidine(TEMP)
  • 2,2,6,6-Tetramethylp
  • 6-TetraMethylpiperidine
  • 2,2,6,6-TetraMethylpiperidine, 98% 10GR
  • 2,2,6,6-TetraMethylpiperidine, 98% 25GR
  • 2,2,6,6-TETRAMETHYLPIPERIDINE FOR SYNTHE
  • 2,2,6,6-TetraMethylpiperidine, 97+%
  • 2,2,6,6-Tetramethylpiperidine USP/EP/BP
  • 2,2,6
  • 2,2,6,6-TETRAMETHYLPIEPERIDINE
  • 2,2,6,6-Tetramethyl piperdine
  • 768-66-1
  • 768661
  • C9H19N
  • AMINE
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  • Piperidines, Piperidones, Piperazines
  • Piperidine
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  • 768-66-1