3-CYANOPYRIDIN-4-YLBORONIC ACID
- Product Name
- 3-CYANOPYRIDIN-4-YLBORONIC ACID
- CAS No.
- 874290-89-8
- Chemical Name
- 3-CYANOPYRIDIN-4-YLBORONIC ACID
- Synonyms
- (3-Cyanopyridin-4-yl)boronic;3-Cyano-4-pyridineboronic Acid;3-CYANOPYRIDINE-4-BORONIC ACID;3-CYANOPYRIDIN-4-YLBORONIC ACID;3-cyano-4-pyridinyl boronic acid;3-Cyanopyridine-4-boronic acid ,95%;B-(3-cyano-4-pyridinyl)-Boronic acid;Boronic acid, B-(3-cyano-4-pyridinyl)-
- CBNumber
- CB2837347
- Molecular Formula
- C6H5BN2O2
- Formula Weight
- 147.93
- MOL File
- 874290-89-8.mol
3-CYANOPYRIDIN-4-YLBORONIC ACID Property
- Boiling point:
- 407.9±55.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.04±0.58(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FC151984
- Product name
- 3-Cyanopyridine-4-boronicacid
- Packaging
- 50mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FC151984
- Product name
- 3-Cyanopyridine-4-boronicacid
- Packaging
- 100mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FC151984
- Product name
- 3-Cyanopyridine-4-boronicacid
- Packaging
- 250mg
- Price
- $535
- Updated
- 2021/12/16
- Product number
- FC151984
- Product name
- 3-Cyanopyridine-4-boronicacid
- Packaging
- 10mg
- Price
- $66
- Updated
- 2021/12/16
- Product number
- FC151984
- Product name
- 3-Cyanopyridine-4-boronicacid
- Packaging
- 25mg
- Price
- $120
- Updated
- 2021/12/16
3-CYANOPYRIDIN-4-YLBORONIC ACID Chemical Properties,Usage,Production
Synthesis
100-54-9
5419-55-6
874290-89-8
Under nitrogen protection, 300 g of anhydrous tetrahydrofuran was added to the reaction flask with stirring turned on, followed by the addition of 12 g of 3-cyanopyridine and cooling of the system to -30°C. The reaction was carried out under nitrogen protection. Slowly 70 mL of 2.0 M n-butyllithium solution was added dropwise. After stirring for 30 minutes, 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane solution was added slowly dropwise. After 2 hours of reaction, 41 mL of triisopropyl borate was slowly added dropwise. Stirring was continued at -30°C for 1 hour, then slowly warmed to room temperature and stirred for 1 hour. To the reaction mixture was added 400 g of concentrated hydrochloric acid and stirred for 1 hour for hydrolysis. After completion of the reaction, the reaction was left to partition and the organic layer was washed with water three times (100 g each). The aqueous layer was combined and extracted once with 100 mL of petroleum ether. The organic layers were combined, dried with 50 g of anhydrous sodium sulfate and filtered. The filtrate was concentrated to dryness to give 14 g of 3-cyano-4-pyridineboronic acid.
References
[1] Patent: CN102718785, 2016, B. Location in patent: Paragraph 0040; 0041
3-CYANOPYRIDIN-4-YLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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