3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE

Product Name: 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
CAS No.: 878194-92-4
Chemical Name: 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
Synonyms: 3-Cyanopyridine-4-boronic;3-Cyano-4-pyridineboronic Acid Pinacol Ester;3-Cyanopyridine-4-boronic acid pinacol ester, tech. 90%;REF DUPL: 3-Cyanopyridine-4-boronic acid, pinacol ester;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile;3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinecarbonitrile;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile;3-Pyridinecarbonitrile, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE ISO 9001：2015 REACH
CBNumber: CB3836756
Molecular Formula: C12H15BN2O2
Formula Weight: 230.07
MOL File: 878194-92-4.mol

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3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Property

Melting point:: 97-99℃
Boiling point:: 369.6±27.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 0.95±0.20(Predicted)
color: Light green

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C987763
Product name: 3-Cyanopyridine-4-boronicacidpinacolester
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC160876
Product name: 3-Cyanopyridine-4-boronic acid pinacol ester
Packaging: 50mg
Price: $44
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC160876
Product name: 3-Cyanopyridine-4-boronic acid pinacol ester
Packaging: 100mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC160876
Product name: 3-Cyanopyridine-4-boronic acid pinacol ester
Packaging: 250mg
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 076902
Product name: 3-Cyanopyridine-4-boronic acid pinacol ester
Packaging: 1g
Price: $238
Updated: 2021/12/16

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3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Chemical Properties,Usage,Production

Uses

3-Cyanopyridine-4-boronic acid pinacol ester

Synthesis

100-54-9

76-09-5

878194-92-4

In a dry 500 mL three-necked flask protected by nitrogen, 2,2,6,6-tetramethylpiperidine (57.6 mmol) was dissolved in anhydrous tetrahydrofuran (200 mL), and after the reaction system was cooled to -10 °C, n-butyllithium (57.6 mmol, 2.5 M hexane solution) was added slowly and dropwise over a period of 2 minutes. After the dropwise addition, stirring was continued for 10 min, followed by cooling the reaction system to -78 °C. Triisopropyl borate (65.3 mmol) was added within 2 min at -78 °C and stirred for 5 min at this temperature. Then, 3-cyanopyridine (48 mmol) dissolved in anhydrous tetrahydrofuran (50 mL) was added with a dropwise addition time of 5 minutes. The reaction mixture was slowly warmed to room temperature in a dry ice bath and stirred overnight. Upon completion of the reaction, the reaction was quenched with glacial acetic acid (67.2 mmol) followed by the addition of pinacol (72 mmol). Stirring was continued for 2 hours at room temperature. The reaction mixture was transferred to a dispensing funnel, diluted by adding dichloromethane (75 mL) and washed with 10% w/v aqueous potassium dihydrogen phosphate solution (4 x 60 mL). The aqueous phase was back-extracted once with dichloromethane (15 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was concentrated under reduced pressure to afford the target product 3-cyano-4-pyridineboronic acid pinacol ester (3b) as a yellow solid in 18% yield with a melting point of 88°C. The product was analyzed by IR, 1H NMR and 1H NDT. The product was characterized by IR, 1H NMR and 13C NMR to confirm the structure.

References

[1] Tetrahedron, 2011, vol. 67, # 32, p. 5806 - 5810

3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Suppliers

China 60 France 1 India 2 Japan 1 United Kingdom 2 United States 12 Global 78

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View Lastest Price from 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 878194-92-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Career Henan Chemical Co

Product: 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 878194-92-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-26

878194-92-4, 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINERelated Search:

3-CYANOPYRIDIN-4-YLBORONIC ACID 3-METHYL-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE 2-Chloro-3-cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE

3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE

3-Cyanopyridine-4-boronic acid pinacol ester, tech. 90%

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile

REF DUPL: 3-Cyanopyridine-4-boronic acid, pinacol ester

3-Cyano-4-pyridineboronic Acid Pinacol Ester

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinecarbonitrile

3-Pyridinecarbonitrile, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE ISO 9001：2015 REACH

3-Cyanopyridine-4-boronic

878194-92-4