3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
- Product Name
- 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
- CAS No.
- 878194-92-4
- Chemical Name
- 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE
- Synonyms
- 3-Cyanopyridine-4-boronic;3-Cyano-4-pyridineboronic Acid Pinacol Ester;3-Cyanopyridine-4-boronic acid pinacol ester, tech. 90%;REF DUPL: 3-Cyanopyridine-4-boronic acid, pinacol ester;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile;3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinecarbonitrile;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile;3-Pyridinecarbonitrile, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB3836756
- Molecular Formula
- C12H15BN2O2
- Formula Weight
- 230.07
- MOL File
- 878194-92-4.mol
3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Property
- Melting point:
- 97-99℃
- Boiling point:
- 369.6±27.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 0.95±0.20(Predicted)
- color
- Light green
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C987763
- Product name
- 3-Cyanopyridine-4-boronicacidpinacolester
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC160876
- Product name
- 3-Cyanopyridine-4-boronic acid pinacol ester
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FC160876
- Product name
- 3-Cyanopyridine-4-boronic acid pinacol ester
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 076902
- Product name
- 3-Cyanopyridine-4-boronic acid pinacol ester
- Packaging
- 1g
- Price
- $238
- Updated
- 2021/12/16
- Product number
- FC160876
- Product name
- 3-Cyanopyridine-4-boronic acid pinacol ester
- Packaging
- 500mg
- Price
- $250
- Updated
- 2021/12/16
3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Chemical Properties,Usage,Production
Uses
3-Cyanopyridine-4-boronic acid pinacol ester
Synthesis
100-54-9
76-09-5
878194-92-4
In a dry 500 mL three-necked flask protected by nitrogen, 2,2,6,6-tetramethylpiperidine (57.6 mmol) was dissolved in anhydrous tetrahydrofuran (200 mL), and after the reaction system was cooled to -10 °C, n-butyllithium (57.6 mmol, 2.5 M hexane solution) was added slowly and dropwise over a period of 2 minutes. After the dropwise addition, stirring was continued for 10 min, followed by cooling the reaction system to -78 °C. Triisopropyl borate (65.3 mmol) was added within 2 min at -78 °C and stirred for 5 min at this temperature. Then, 3-cyanopyridine (48 mmol) dissolved in anhydrous tetrahydrofuran (50 mL) was added with a dropwise addition time of 5 minutes. The reaction mixture was slowly warmed to room temperature in a dry ice bath and stirred overnight. Upon completion of the reaction, the reaction was quenched with glacial acetic acid (67.2 mmol) followed by the addition of pinacol (72 mmol). Stirring was continued for 2 hours at room temperature. The reaction mixture was transferred to a dispensing funnel, diluted by adding dichloromethane (75 mL) and washed with 10% w/v aqueous potassium dihydrogen phosphate solution (4 x 60 mL). The aqueous phase was back-extracted once with dichloromethane (15 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was concentrated under reduced pressure to afford the target product 3-cyano-4-pyridineboronic acid pinacol ester (3b) as a yellow solid in 18% yield with a melting point of 88°C. The product was analyzed by IR, 1H NMR and 1H NDT. The product was characterized by IR, 1H NMR and 13C NMR to confirm the structure.
References
[1] Tetrahedron, 2011, vol. 67, # 32, p. 5806 - 5810
3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Suppliers
- Tel
- --
- Fax
- --
- info@borochem.fr
- Country
- France
- ProdList
- 852
- Advantage
- 46
View Lastest Price from 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE manufacturers
- Product
- 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 878194-92-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 3-CYANO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 878194-92-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-26