ChemicalBook > CAS DataBase List > 2,2,6,6-Tetramethylpiperidine

2,2,6,6-Tetramethylpiperidine

Product Name
2,2,6,6-Tetramethylpiperidine
CAS No.
768-66-1
Chemical Name
2,2,6,6-Tetramethylpiperidine
Synonyms
HTMP;TETRAMETHYLPIPERIDINE;2,2,6,6-TetramethyL;6-TetraMethylpiperidine;2,2,6,6-Teteamethyl-piperidine;2,2,6,6-Tetramethylpiperidine(Tmp);2,2,6;Norpempidine;2,2,6,6-Tetramethylp;2,2,6,6-tetramethyl-piperidin
CBNumber
CB3320372
Molecular Formula
C9H19N
Formula Weight
141.25
MOL File
768-66-1.mol
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2,2,6,6-Tetramethylpiperidine Property

Melting point:
-59°C
Boiling point:
152 °C (lit.)
Density 
0.837 g/mL at 25 °C (lit.)
vapor pressure 
14 hPa (39 °C)
refractive index 
n20/D 1.445(lit.)
Flash point:
76 °F
storage temp. 
Store below +30°C.
solubility 
MISCIBLE
pka
11.07(at 25℃)
form 
Liquid
Specific Gravity
0.837
color 
Clear colorless to yellow
Water Solubility 
MISCIBLE
Sensitive 
Air Sensitive
BRN 
103296
InChIKey
RKMGAJGJIURJSJ-UHFFFAOYSA-N
CAS DataBase Reference
768-66-1(CAS DataBase Reference)
NIST Chemistry Reference
Piperidine, 2,2,6,6-tetramethyl-(768-66-1)
EPA Substance Registry System
Piperidine, 2,2,6,6-tetramethyl- (768-66-1)
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Safety

Hazard Codes 
Xn,F,C
Risk Statements 
10-22-36/37/38
Safety Statements 
26-37/39-16
RIDADR 
UN 1992 3/PG 3
WGK Germany 
2
RTECS 
TN4220000
Autoignition Temperature
290 °C
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29333999
Toxicity
LD50 orally in Rabbit: 500 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H290May be corrosive to metals

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.18132
Product name
2,2,6,6-Tetramethylpiperidine
Purity
for synthesis
Packaging
25mL
Price
$114
Updated
2024/03/01
Sigma-Aldrich
Product number
115754
Product name
2,2,6,6-Tetramethylpiperidine
Purity
≥99%
Packaging
5g
Price
$44.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18132
Product name
2,2,6,6-Tetramethylpiperidine
Purity
for synthesis
Packaging
100mL
Price
$205
Updated
2024/03/01
Sigma-Aldrich
Product number
115754
Product name
2,2,6,6-Tetramethylpiperidine
Purity
≥99%
Packaging
10g
Price
$84
Updated
2024/03/01
TCI Chemical
Product number
T1051
Product name
2,2,6,6-Tetramethylpiperidine
Purity
>98.0%(GC)(T)
Packaging
25mL
Price
$113
Updated
2024/03/01
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2,2,6,6-Tetramethylpiperidine Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow-green liquid

Uses

2,2,6,6-Tetramethylpiperidine is a hindered base used to prepare metallo-amide bases and selective generation of silylketene acetals. It is used in the preparation of hibarimicinone, (Z)-silylketene acetal and 4-substituted quinazoline. It acts as a precursor to Lithium tetramethylpiperidide and (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl radical.

Uses

2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors.

Uses

The lithium amide has been used to efficiently ortho deprotonate pyridine-3-carboxamides.

Preparation

Many routes for the synthesis of TMP have been reported. One method starts with a conjugate addition reaction of ammonia to phorone. The intermediate triacetone amine is then reduced in a Wolff-Kishner reaction.

2,2,6,6-Tetramethylpiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

2-METHOXY-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 5-Fluoro-2-picolinic acid 5-FORMYL-2,4-DIMETHOXYPYRIMIDINE 3-BROMO-2-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE (E)-5-(2-CARBOXYVINYL)-2,4-DIMETHOXYPYRIMIDINE 3-CYANOPYRIDIN-4-YLBORONIC ACID 5-(TRIFLUOROMETHYL)-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2-CHLORO-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2-CYANOPYRIDIN-3-YLBORONIC ACID 3-METHOXY-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 4-(TRIFLUOROMETHYL)-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE TEMPO 6-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID 2-(TRIFLUOROMETHYL)-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2-CYANO-5-BROMOPHENYLBORONIC ACID PINACOL ESTER 2-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID 4-CYANOPYRIDIN-3-YLBORONIC ACID 2-BROMO-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 4-CHLORO-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2-(TRIFLUOROMETHYL)-4-ISOCYANATOPYRIDINE 3-FLUORO-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE
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2,2,6,6-Tetramethylpiperidine Suppliers

Belgium 2 Canada 2 China 359 Czech Republic 1 Europe 2 France 1 Germany 10 India 14 Italy 1 Japan 7 Poland 2 Slovakia 2 South Korea 2 Switzerland 4 Ukraine 1 United Kingdom 23 United States 49 Global 482
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Koei Chemical Co., Ltd.
Tel
--
Fax
--
Country
Japan
ProdList
127
Advantage
58
FUJIFILM Wako Pure Chemical Corporation
Tel
--
Fax
--
Email
ffwk-cservice@fujifilm.com
Country
Japan
ProdList
6222
Advantage
58
TCI Japan
Tel
--
Fax
--
Email
@TCIchemicals.com
Country
Japan
ProdList
2741
Advantage
58
Nacalai Tesque, Inc.
Tel
--
Fax
--
Email
info-tech@nacalai.co.jp
Country
Japan
ProdList
6046
Advantage
75
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
--
Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
Advantage
80
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74
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View Lastest Price from 2,2,6,6-Tetramethylpiperidine manufacturers

Nanjing Liskon Biological Technology Co., Ltd
Product
2,2,6,6-tetramethyl-piperidin 768-66-1
Price
US $0.00/KG
Min. Order
25KG
Purity
≥99.0%
Supply Ability
5tons
Release date
2024-06-14
Henan Aochuang Chemical Co.,Ltd.
Product
2,2,6,6-Tetramethylpiperidine 768-66-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Hebei Zhanyao Biotechnology Co. Ltd
Product
2,2,6,6-Tetramethylpiperidine 768-66-1
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-17

768-66-1, 2,2,6,6-TetramethylpiperidineRelated Search:

2,6-Lutidine 4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE PURUM 97%,4-Amine-2,2,6,6-Tetramethylpiperidine DROPERIDOL Haloperidol 2,2,6,6-Tetramethylpiperidinooxy 2,2,6,6-Tetramethyl-4-piperidinol Triacetonamine Diphenoxylate PHENCYCLIDINE-D5 HYDROCHLORIDE 4-Oxo-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical 4-Amino-TEMPO, free radical 2,2,6,6-Tetramethyl-4-piperidone hydrochloride 3,5-Dibromo-4-oxo-2,2,6,6-tetramethylpiperidin-1-yl 1,2,2,6,6-PENTAMETHYLPIPERIDINE 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical,4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl, TEMPOL Light Stabilizer 770 Light Stabilizer-944 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical [Catalyst for Oxidation],4-Acetamido-2,2,6,6-tetramethylpiperidine N-oxyl

  • HTMP
  • 2,2,6,6-TETRAMETHYLPIPERIDINE
  • 2,2,6,6-TetramethyL
  • 2,2,6,6-Teteamethyl-piperidine
  • 2,2,6,6-Tetramethylpiperidine(Tmp)
  • 2,2,6,6-tetramethyl-piperidin
  • Norpempidine
  • 2,2,6,6-Tetramethylpiperidine (HTMP)
  • 2,2,6,6-Tetramethylpiperidine, 98+%
  • 2,2,6,6-TETRAMETHYLPIPERIDINE, 99+%
  • 2,2,6,6-Tetramethylpiperidien
  • TETRAMETHYLPIPERIDINE
  • Piperidine, 2,2,6,6-tetramethyl-
  • 2,2,6,6-tetramethylpiperidine(TEMP)
  • 2,2,6,6-Tetramethylp
  • 6-TetraMethylpiperidine
  • 2,2,6,6-TetraMethylpiperidine, 98% 10GR
  • 2,2,6,6-TetraMethylpiperidine, 98% 25GR
  • 2,2,6,6-TETRAMETHYLPIPERIDINE FOR SYNTHE
  • 2,2,6,6-TetraMethylpiperidine, 97+%
  • 2,2,6,6-Tetramethylpiperidine USP/EP/BP
  • 2,2,6
  • 2,2,6,6-TETRAMETHYLPIEPERIDINE
  • 2,2,6,6-Tetramethyl piperdine
  • 768-66-1
  • 768661
  • C9H19N
  • AMINE
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  • 768-66-1