5-Fluoro-2-picolinic acid
Uses- Product Name
- 5-Fluoro-2-picolinic acid
- CAS No.
- 107504-08-5
- Chemical Name
- 5-Fluoro-2-picolinic acid
- Synonyms
- 5-FLUOROPICOLINIC ACID;5-FLUOROPYRIDINE-2-CARBOXYLIC ACID;EOS-60510;5-Fluoropicolinicaci;5-FLUORO-2-PICOLINIC ACID;5-Fluoropyridine-2-carboxylic;2-carboxylate - 5-fluoropyridine;5-Fluoropyrdine-2-carboxylic acid;5-fluoropyridin-2-carboxylic acid;5-Fluoropyridin-2-ylpicolinicacid
- CBNumber
- CB1143357
- Molecular Formula
- C6H4FNO2
- Formula Weight
- 141.1
- MOL File
- 107504-08-5.mol
5-Fluoro-2-picolinic acid Property
- Melting point:
- 164-166℃
- Boiling point:
- 275.1±20.0 °C(Predicted)
- Density
- 1.419±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 3.58±0.10(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C6H4FNO2/c7-4-1-2-5(6(9)10)8-3-4/h1-3H,(H,9,10)
- InChIKey
- JTKFIIQGMVKDNZ-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC=C(F)C=C1
- CAS DataBase Reference
- 107504-08-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0838
- Product name
- 5-Fluoro-2-pyridinecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- F0838
- Product name
- 5-Fluoro-2-pyridinecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $150
- Updated
- 2025/07/31
- Product number
- F621140
- Product name
- 5-Fluoropicolinicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC5246
- Product name
- 5-Fluoropyridine-2-carboxylicacid
- Purity
- 98%
- Packaging
- 25g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- F11153
- Product name
- 5-Fluoropyridine-2-carboxylicacid
- Purity
- 95%
- Packaging
- 25g
- Price
- $120
- Updated
- 2021/12/16
5-Fluoro-2-picolinic acid Chemical Properties,Usage,Production
Uses
5-Fluoro-2-pyridinecarboxylic acid, a common organic synthetic intermediate, is mainly used for the structural modification and derivatization of pyridine-containing drug molecules and bioactive molecules. The carboxyl group on the pyridine ring can be converted to an ester group, but acid-promoted esterification is generally not used. A more common approach is to first convert the carboxyl group to an acyl chloride using sulfoxide, followed by the addition of an alcohol to convert it to an ester group. Furthermore, the carboxyl group on this compound can also be converted to a trifluoromethyl group. Finally, the nitrogen atom on the pyridine ring can also be oxidized to nitrogen oxides.
Synthesis
Potassium phosphate monobasic (1.4 g, 10 mmol) in water (10 mL) was added to a solution of 5-fluoropyridine-2-carbaldehyde (0.50 g, 4.0 mmol, Frontier) in DMSO (10 mL). Sodium chlorite (0.9 g, 0.008 mol) in water (10 mL) was added, and the reaction continued for 1 hour. The mixture was saturated with NaCl, then diluted with EtOAc. The organic layer was further washed with brine, dried over sodium sulfate and concentrated to afford 5-FLUORO-2-PICOLINIC ACID (370 mg, 65%).
References
[1] Patent: WO2011/28685, 2011, A1. Location in patent: Page/Page column 85; 86
5-Fluoro-2-picolinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluoro-2-picolinic acid manufacturers
- Product
- 5-Fluoro-2-picolinic acid 107504-08-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 5-FLUORO-2-PICOLINIC ACID 107504-08-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 5-FLUORO-2-PICOLINIC ACID 107504-08-5
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08