ChemicalBook > CAS DataBase List > 5-Fluoro-2-picolinic acid

5-Fluoro-2-picolinic acid

Uses

Product Name: 5-Fluoro-2-picolinic acid
CAS No.: 107504-08-5
Chemical Name: 5-Fluoro-2-picolinic acid
Synonyms: 5-FLUOROPICOLINIC ACID;5-FLUOROPYRIDINE-2-CARBOXYLIC ACID;EOS-60510;5-Fluoropicolinicaci;5-FLUORO-2-PICOLINIC ACID;5-Fluoropyridine-2-carboxylic;2-carboxylate - 5-fluoropyridine;5-Fluoropyrdine-2-carboxylic acid;5-fluoropyridin-2-carboxylic acid;5-Fluoropyridin-2-ylpicolinicacid
CBNumber: CB1143357
Molecular Formula: C6H4FNO2
Formula Weight: 141.1
MOL File: 107504-08-5.mol

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5-Fluoro-2-picolinic acid Property

Melting point:: 164-166℃
Boiling point:: 275.1±20.0 °C(Predicted)
Density: 1.419±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 3.58±0.10(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C6H4FNO2/c7-4-1-2-5(6(9)10)8-3-4/h1-3H,(H,9,10)
InChIKey: JTKFIIQGMVKDNZ-UHFFFAOYSA-N
SMILES: C1(C(O)=O)=NC=C(F)C=C1
CAS DataBase Reference: 107504-08-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0838
Product name: 5-Fluoro-2-pyridinecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: F0838
Product name: 5-Fluoro-2-pyridinecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $150
Updated: 2025/07/31

TRC

Product number: F621140
Product name: 5-Fluoropicolinicacid
Packaging: 1g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC5246
Product name: 5-Fluoropyridine-2-carboxylicacid
Purity: 98%
Packaging: 25g
Price: $98
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: F11153
Product name: 5-Fluoropyridine-2-carboxylicacid
Purity: 95%
Packaging: 25g
Price: $120
Updated: 2021/12/16

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5-Fluoro-2-picolinic acid Chemical Properties,Usage,Production

Uses

5-Fluoro-2-pyridinecarboxylic acid, a common organic synthetic intermediate, is mainly used for the structural modification and derivatization of pyridine-containing drug molecules and bioactive molecules. The carboxyl group on the pyridine ring can be converted to an ester group, but acid-promoted esterification is generally not used. A more common approach is to first convert the carboxyl group to an acyl chloride using sulfoxide, followed by the addition of an alcohol to convert it to an ester group. Furthermore, the carboxyl group on this compound can also be converted to a trifluoromethyl group. Finally, the nitrogen atom on the pyridine ring can also be oxidized to nitrogen oxides.

Synthesis

Potassium phosphate monobasic (1.4 g, 10 mmol) in water (10 mL) was added to a solution of 5-fluoropyridine-2-carbaldehyde (0.50 g, 4.0 mmol, Frontier) in DMSO (10 mL). Sodium chlorite (0.9 g, 0.008 mol) in water (10 mL) was added, and the reaction continued for 1 hour. The mixture was saturated with NaCl, then diluted with EtOAc. The organic layer was further washed with brine, dried over sodium sulfate and concentrated to afford 5-FLUORO-2-PICOLINIC ACID (370 mg, 65%).

References

[1] Patent: WO2011/28685, 2011, A1. Location in patent: Page/Page column 85; 86

5-Fluoro-2-picolinic acid Preparation Products And Raw materials

Raw materials

Hexane Nitrogen Ammonium formate 2,2,6,6-Tetramethylpiperidine Chlorotrimethylsilane Carbon dioxide 3-Fluoropyridine 2-Dimethylaminoethanol Tetrahydrofuran Hydrochloric acid Methanol 1,1,2-Trichlorotrifluoroethane Tetrabutylammonium fluoride HEAVY DISTILLATE n-Butyllithium

Preparation Products

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View Lastest Price from 5-Fluoro-2-picolinic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Fluoro-2-picolinic acid 107504-08-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-03

Henan Aochuang Chemical Co.,Ltd.

Product: 5-FLUORO-2-PICOLINIC ACID 107504-08-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Henan Fengda Chemical Co., Ltd

Product: 5-FLUORO-2-PICOLINIC ACID 107504-08-5
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

107504-08-5, 5-Fluoro-2-picolinic acidRelated Search:

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107504-08-5

pharmacetical

PYRIDINE

CARBOXYLICACID

Building Blocks

Pyridines derivates

Pyridines

Pyridine series