1-N-Boc-3-Methylpiperidine-3-carboxylic acid
- Product Name
- 1-N-Boc-3-Methylpiperidine-3-carboxylic acid
- CAS No.
- 534602-47-6
- Chemical Name
- 1-N-Boc-3-Methylpiperidine-3-carboxylic acid
- Synonyms
- 1-BOC-3-METHYLPIPECOLINIC ACID;1-Boc-3-Methyl-3-piperidinecarboxylic acid;1-N-Boc-3-Methylpiperidine-3-carboxylic acid;1-Boc-3-methylpiperidine-3-carboxylic acid - [M14145];1-(TERT-BUTOXYCARBONYL)-3-METHYLPIPERIDINE-3-CARBOXYLATE;3-Methyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester;1-(tert-Butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid;3-Methyl-1,3-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) ester;1,3-Piperidinedicarboxylic acid, 3-methyl-, 1-(1,1-dimethylethyl) ester;1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid(SALTDATA: FREE)
- CBNumber
- CB31503941
- Molecular Formula
- C12H21NO4
- Formula Weight
- 243.3
- MOL File
- 534602-47-6.mol
1-N-Boc-3-Methylpiperidine-3-carboxylic acid Property
- Boiling point:
- 354.3±35.0 °C(Predicted)
- Density
- 1.129
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.53±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B656920
- Product name
- N-Boc-3-methylpiperidine-3-carboxylicAcid
- Packaging
- 5g
- Price
- $580
- Updated
- 2021/12/16
- Product number
- 4H58-1-QT
- Product name
- 1-[(tert-Butoxy)carbonyl]-3-methylpiperidine-3-carboxylic acid
- Purity
- 97.0%
- Packaging
- 5G
- Price
- $940
- Updated
- 2021/12/16
- Product number
- 4H58-1-QT
- Product name
- 1-[(tert-Butoxy)carbonyl]-3-methylpiperidine-3-carboxylic acid
- Purity
- 97.0%
- Packaging
- 25g
- Price
- $1590
- Updated
- 2021/12/16
- Product number
- W6785
- Product name
- 1-Boc-3-Methylpipecolinicacid
- Packaging
- 5g
- Price
- $249
- Updated
- 2021/12/16
- Product number
- CHM1052044
- Product name
- 1-[(TERT-BUTOXY)CARBONYL]-3-METHYLPIPERIDINE-3-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $456.73
- Updated
- 2021/12/16
1-N-Boc-3-Methylpiperidine-3-carboxylic acid Chemical Properties,Usage,Production
Uses
N-Boc-3-methylpiperidine-3-carboxylic Acid is used as a reagent in the synthesis of tricyclic heterocyclic compounds as JAK1 inhibitors useful in the treatment of immunological and hyperproliferative disorders.
Synthesis
888952-55-4
534602-47-6
Step 2. Hydrolysis reaction: To a mixed solution of methyl 1-Boc-3-methylpiperidine-3-carboxylate (15.86 g, 0.062 mol) in THF (100 ml) and water (10 ml), lithium hydroxide monohydrate (LiOH-H2O, 7.76 g, 0.186 mol) was added at room temperature. The reaction mixture was heated to 70 °C and refluxed for 6 hours. The progress of the reaction was monitored by TLC (unfolding agent: petroleum ether/ethyl acetate, 4:1, iodine color development), and after confirming that the raw material was completely consumed, the mixture was concentrated to dryness. The residue was diluted with deionized water (300 mL) and subsequently extracted with methyl tert-butyl ether (MTBE, 100 mL x 2) and the organic layer was discarded. The aqueous layer was acidified to pH 1 with 1 M aqueous hydrochloric acid and extracted with MTBE (100 mL × 2). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated to dryness to give 1-Boc-3-methylpiperidine-3-carboxylic acid (13.97 g, 93% yield) as a white solid.
References
[1] Patent: US2015/158864, 2015, A1. Location in patent: Paragraph 0487
[2] Patent: US2007/82900, 2007, A1. Location in patent: Page/Page column 158
1-N-Boc-3-Methylpiperidine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-N-Boc-3-Methylpiperidine-3-carboxylic acid manufacturers
- Product
- 1-N-Boc-3-Methylpiperidine-3-carboxylic acid 534602-47-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-09