Nipecotic acid
- Product Name
- Nipecotic acid
- CAS No.
- 498-95-3
- Chemical Name
- Nipecotic acid
- Synonyms
- PIPERIDINE-3-CARBOXYLIC ACID;3-PIPERIDINECARBOXYLIC ACID;H-NIP-OH;DL-Nip-OH;H-D-NIPC-OH;H-DL-Nip-OH;H-DL-NIPC-OH;nipecoticaci;H-DL-PIC(3)-OH;NIPECOTIC ACID
- CBNumber
- CB2357287
- Molecular Formula
- C6H11NO2
- Formula Weight
- 129.16
- MOL File
- 498-95-3.mol
Nipecotic acid Property
- Melting point:
- 261 °C (dec.) (lit.)
- Boiling point:
- 239.22°C (rough estimate)
- Density
- 1.1426 (rough estimate)
- refractive index
- 1.4587 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- water: soluble50mg/mL, clear, colorless to faintly yellow
- form
- Solid
- pka
- pK1:3.35(+1);pK2:10.64(0) (25°C)
- color
- White
- Water Solubility
- Soluble in water
- Merck
- 14,6560
- BRN
- 81096
- InChI
- InChI=1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)
- InChIKey
- XJLSEXAGTJCILF-UHFFFAOYSA-N
- SMILES
- N1CCCC(C(O)=O)C1
- CAS DataBase Reference
- 498-95-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- TM6125380
- HazardClass
- IRRITANT
- HS Code
- 29339900
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 211672
- Product name
- Nipecotic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $35.5
- Updated
- 2023/01/07
- Product number
- 211672
- Product name
- Nipecotic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $38.9
- Updated
- 2023/01/07
- Product number
- N0420
- Product name
- 3-Piperidinecarboxylic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $63
- Updated
- 2025/07/31
- Product number
- N0420
- Product name
- 3-Piperidinecarboxylic Acid
- Purity
- >98.0%(T)
- Packaging
- 500g
- Price
- $561
- Updated
- 2025/07/31
- Product number
- 211672
- Product name
- Nipecotic acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $94.6
- Updated
- 2023/01/07
Nipecotic acid Chemical Properties,Usage,Production
Chemical Properties
off-white to pale yellow-beige powder
Uses
(+/-)-Nipecotic Acid (cas# 498-95-3) is a compound useful in organic synthesis.
Definition
ChEBI: A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group.
Synthesis Reference(s)
The Journal of Organic Chemistry, 28, p. 602, 1963 DOI: 10.1021/jo01037a531
General Description
R(?)-Nipecotic acid is a potential inhibitor of uptake of γ-aminobutyric acid (GABA) in rat brain slices. Lipophilic derivatives of nipecotic acid are used as drugs for the treatment of epilepsy.
Synthesis
93-60-7
498-95-3
The general procedure for the synthesis of 3-piperidinecarboxylic acid from methyl nicotinate was as follows: 0.25 g of methyl nicotinate with HRO/Na-β catalyst (50 mg) in 40 mL of deionized water was added to the reactor. Subsequently, the reactor was subjected to hydrogen pressure of 15 bar and heated at 120 °C for 1 h of reaction. Upon completion of the reaction, the catalyst was separated by centrifugation and the resulting mixture of clarified products was analyzed using GC-MS. The reaction achieved 100% conversion of methyl nicotinate and gave 3-piperidinecarboxylic acid in 100% yield.
References
[1] Patent: WO2017/60922, 2017, A1. Location in patent: Page/Page column 15; 22
Nipecotic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from Nipecotic acid manufacturers
- Product
- Nipecotic acid 498-95-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-08
- Product
- Nipecotic acid 498-95-3
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-06-26
- Product
- Nipecotic acid 498-95-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2020-07-16