Synthesis
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Ethyl 1-benzylpiperidine-4-carboxylate

Synthesis
Product Name
Ethyl 1-benzylpiperidine-4-carboxylate
CAS No.
24228-40-8
Chemical Name
Ethyl 1-benzylpiperidine-4-carboxylate
Synonyms
AKOS 225-01;BUTTPARK 33\04-91;RSYY(Avanafil)-28;RARECHEM AH CK 0037;SDCCGMLS-0066147.P001;Ethyl 1-Benzylisonipecotate;Ethyl N-benzylisonipecotate;1-benzyl-ethyl Isonipecotate;Ethyl N-benzylisonipecotinate;1-Benzyl-4-piperidinecarboxyli
CBNumber
CB4276544
Molecular Formula
C15H21NO2
Formula Weight
247.33
MOL File
24228-40-8.mol
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Ethyl 1-benzylpiperidine-4-carboxylate Property

Boiling point:
122°C (0.5 mmHg)
Density 
1.037 g/mL at 25 °C
refractive index 
1.5120-1.5160
Flash point:
>110℃
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Hexanes (Slightly), Methanol (Slightly)
form 
clear liquid
pka
7.93±0.10(Predicted)
color 
Colorless to Light red
CAS DataBase Reference
24228-40-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-25
Safety Statements 
24/25-45
RIDADR 
UN 2810 6.1 / PGIII
Hazard Note 
Irritant
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical
Product number
E0862
Product name
Ethyl 1-Benzyl-4-piperidinecarboxylate
Purity
>95.0%(GC)(T)
Packaging
5g
Price
$57
Updated
2023/06/20
TCI Chemical
Product number
E0862
Product name
Ethyl 1-Benzyl-4-piperidinecarboxylate
Purity
>95.0%(GC)(T)
Packaging
25g
Price
$203
Updated
2021/12/16
Alfa Aesar
Product number
H52374
Product name
Ethyl 1-benzylpiperidine-4-carboxylate, 97+%
Packaging
5g
Price
$87.7
Updated
2021/12/16
Alfa Aesar
Product number
H52374
Product name
Ethyl 1-benzylpiperidine-4-carboxylate, 97+%
Packaging
1g
Price
$26.5
Updated
2021/12/16
Alfa Aesar
Product number
H52374
Product name
Ethyl 1-benzylpiperidine-4-carboxylate, 97+%
Packaging
250mg
Price
$9.6
Updated
2021/12/16
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Ethyl 1-benzylpiperidine-4-carboxylate Chemical Properties,Usage,Production

Synthesis

Ethyl isonipecotate (50 g, 0.31 mol) was dissolved in toluene (150 mL) in a round bottom flask, charged with potassium carbonate (60 g, 0.43 mol) and stirred for 15 min. Benzyl chloride (42 g, 0.31 mol) was charged and the reaction mass was refluxed for 4 h at 100 °C. Upon completion of the reaction as marked by TLC (hexane:ethyl acetate; 2:1), the reaction mass was cooled to room temperature and quenched with water (100 mL), stirred and the organic phase was separated. The aqueous phase was again extracted with toluene (100 mL). Combined organic phase was washed twice with saturated brine solution (50 mL). Remove toluene in vacuo to obtain Ethyl N-benzylpiperidine-4-carboxylate ( 6.97 g, 91 %) as a yellow liquid.

Chemical Properties

Colourless Oil

Ethyl 1-benzylpiperidine-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 1-benzylpiperidine-4-carboxylate Suppliers

Anhui Dexinjia Biopharm Co., Ltd
Tel
0531-82375878 15269101859
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2710825968@qq.com
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China
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Shanghai Hobor Chemical Co., Ltd
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21-21-61026752 13918007836
Fax
021-51685238
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sales@hoborchem.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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future industrial shanghai co., ltd
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400-0066400 13621662912
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021-55660885
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sales@jonln.com
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China
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
Country
China
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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China
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Shijiazhuang Sdyano Fine Chemical Co., Ltd.
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0311-89250318 031166536426
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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Capot Chemical Co., Ltd
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View Lastest Price from Ethyl 1-benzylpiperidine-4-carboxylate manufacturers

Hebei Kingfiner Technology Development Co.Ltd
Product
Ethyl N-benzylpiperidine-4-carboxylate 24228-40-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2023-12-12
Wuhan Xinhao Biotechnology Co., Ltd
Product
Ethyl 1-benzylpiperidine-4-carboxylate 24228-40-8
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Metric Ton/Month
Release date
2024-03-20
Hebei Fengqiang Trading Co., LTD
Product
Ethyl N-benzyl piperidine-4-carboxylate 24228-40-8
Price
US $100.00/bag
Min. Order
1bag
Purity
99
Supply Ability
5000
Release date
2023-09-11

24228-40-8, Ethyl 1-benzylpiperidine-4-carboxylateRelated Search:


  • RARECHEM AH CK 0037
  • AKOS 225-01
  • 1-BENZYLPIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER
  • ETHYL 1-BENZYL-4-PIPERIDINECARBOXYLATE
  • ETHYL 1-BENZYLPIPERIDINE-4-CARBOXYLATE
  • BUTTPARK 33\04-91
  • 1-(Phenylmethyl)-4-piperidinecarboxylic Acid Ethyl Ester
  • 1-(Phenylmethyl)piperidine-4-carboxylic Acid Ethyl Ester
  • Ethyl 1-Benzylisonipecotate
  • Ethyl 1-Benzylpiperidine-4-carboxylat
  • N-Benzyl-4-carboethoxypiperidine
  • 1-Benzyl-4-piperidinecarboxyli
  • N-Benzyl-4-piperidinecarboxylicacidethylester
  • Methyl(ethyl) 1-benzyl-Piperidine-4-carboxylate
  • 1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER >98%
  • Benzylpiperidinecarboxylicacidethylester
  • N-Benzyl-4-cabethoxypiperidine
  • Ethyl 1-benzylpiperidine-4-carboxylate, 97+%
  • 4-Piperidinecarboxylic acid, 1-(phenylMethyl)-, ethyl ester
  • N-Ethyl N-benzylpiperidine-4-carboxylate
  • Ethyl N-benzylpiperidine-4-carboxylate
  • Ethyl-benzylpiperidine-4-carboxylate
  • 1-Benzyl-4-piperidinecarboxylic Acid Ethyl Ester Ethyl 1-Benzylisonipecotate 1-Benzylisonipecotic Acid Ethyl Ester
  • Ethyl 1-benzylisonipecotate, 1-Benzyl-4-(ethoxycarbonyl)piperidine
  • N-benzyl -4-piperidine forMic acid ethyl ester
  • 1 - benzyl - 4 - piperidine ethyl forMate
  • Ethyl N-benzyl-4-piperidinecarboxylate
  • CAS NO.24228-40-8 Ethyl N-benzylpiperidine-4-carboxylate
  • SDCCGMLS-0066147.P001
  • Ethyl1-Benzyl-4-piperidinecarboxylate&gt
  • Ethyl N-benzylisonipecotinate
  • N-benzyl isonipecotic ethyl ester
  • N-benzylpiperidine-4-carboxylate, ethyl ester
  • 1-Benzylisonipecotic Acid Ethyl Ester
  • 1-benzyl-ethyl Isonipecotate
  • 1-Benzyl-piperidine-4-carboxylic a
  • RSYY(Avanafil)-28
  • Ethyl N-benzylisonipecotate
  • 24228-40-8
  • 24228-04-8
  • 12001-70-3
  • C24H29NO3HCl
  • Piperidine
  • Heterocyclic Compounds
  • Aromatics
  • Heterocycles