N-Benzyl-4-piperidone

Product Name: N-Benzyl-4-piperidone
CAS No.: 3612-20-2
Chemical Name: N-Benzyl-4-piperidone
Synonyms: 1-BENZYLPIPERIDIN-4-ONE;1-BENZYL-4-PIPERIDONE;Benzyl piperidone;N-Benzylpiperidin-4-one;NSC 77933;-4-piperidone;N-BENZYLPIPERIDONE;1-Benzylpiperidone;BENZYLPIPERIDONE-4;Benzamide,7-bromo-
CBNumber: CB8341198
Molecular Formula: C12H15NO
Formula Weight: 189.25
MOL File: 3612-20-2.mol

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N-Benzyl-4-piperidone Property

Boiling point:: 134 °C7 mm Hg(lit.)
Density: 1.021 g/mL at 25 °C(lit.)
vapor pressure: 0.079-0.15Pa at 20-25℃
refractive index: n20/D 1.541(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: 12g/l
form: Oily Liquid
pka: 7.07±0.20(Predicted)
Specific Gravity: 1.021
color: Clear colorless to straw
Water Solubility: 12 g/L (20 ºC)
BRN: 128556
LogP: 2.1 at 20℃ and pH9
CAS DataBase Reference: 3612-20-2(CAS DataBase Reference)
NIST Chemistry Reference: 4-Piperidinone, 1-(phenylmethyl)-(3612-20-2)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-43-22-20/21/22
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B29806
Product name: 1-Benzyl-4-piperidone
Purity: 99%
Packaging: 25g
Price: $41.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: B29806
Product name: 1-Benzyl-4-piperidone
Purity: 99%
Packaging: 100g
Price: $80.1
Updated: 2024/03/01

TCI Chemical

Product number: B1027
Product name: 1-Benzyl-4-piperidone
Purity: >98.0%(GC)(T)
Packaging: 25mL
Price: $30
Updated: 2024/03/01

TCI Chemical

Product number: B1027
Product name: 1-Benzyl-4-piperidone
Purity: >98.0%(GC)(T)
Packaging: 500mL
Price: $282
Updated: 2024/03/01

Alfa Aesar

Product number: A12390
Product name: 1-Benzyl-4-piperidone, 98+%
Packaging: 25g
Price: $28.65
Updated: 2024/03/01

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N-Benzyl-4-piperidone Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to straw coloured oily liquid

Uses

A substituted piperidine as pesticide

Uses

1-Benzyl-4-piperidone is a pharmaceutical intermediate, it is used in penfluridol synthesis of bulk drugs.

Reactions

As an important organic compound, N-Benzyl-4-piperidone could be used to synthesize many organic compounds. There are four ways to synthesize 1-benzylpiperidine-4-carbaldehyde using it as the raw material. The first method involves the Wittig reaction of (methoxymethyl) triphenylphosphonium chloride with N-benzyl-4-piperidone, followed by hydrolysis of the resulting enol ether. In another method, trimethylsilyl diazomethane is condensed with N-benzyl-4-piperidone, followed by hydrolysis to obtain the final product. In a third route, N-benzyl-4-piperidone is treated with trimethyloxosulfonium iodide to produce the corresponding epoxide. The epoxide is then rearranged in the presence of magnesium bromide etherate, resulting in 1-benzylpiperidine-4-carbaldehyde with high yields. In 2007, a patent described the Darzens condensation of N-benzyl-4-piperidone with ethyl chloroacetate, followed by decarboxylation[1].

Purification Methods

If the physical properties show contamination, then dissolve it in the minimum volume of H2O, made strongly alkaline with aqueous KOH, extract it with toluene several times, dry the extract with K2CO3, filter, evaporate and distil the residue at high vacuum using a bath temperature of 160-190o, and redistil it. [Brookes & Walker J Chem Soc 3173 1957, Bolyard J Am Chem Soc 52 1030 1930.] The hydrochloride has m 159-161o (from Me2CO/Et2O), and the picrate has m 174-182o (from Me2CO/Et2O). [Grob & Brenneisen Helv Chim Acta 41 1184 1958, Beilstein 21/6 V 424.]

References

[1] Chavakula R, et al. Industrially Viable Preparation ofN-Benzyl-4-formylpiperidine, a Key Intermediate of Donepezil. Organic Preparations and Procedures International, 2013; 45: 168-170.

N-Benzyl-4-piperidone Preparation Products And Raw materials

Raw materials

Benzylamine Methyl propionate 4,4-Piperidinediol hydrochloride

Preparation Products

N-Boc-2-piperidone 4,5,6,7-TETRAHYDRO-2-METHYLFURO[3,2-C]PYRIDINE 1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE 4-(3-Trifuoromethyl)phenyl-4-piperidinol 1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL 1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4S)-(9CI) 4-(1-Pyrrolidinyl)piperidine 1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4R)-(9CI)

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N-Benzyl-4-piperidone Suppliers

Americas 1 Belgium 2 Canada 3 China 431 Europe 4 France 2 Germany 9 India 24 Japan 7 Slovakia 1 South Korea 4 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 20 United States 70 Global 584

Anhui Dexinjia Biopharm Co., Ltd

Tel: 0531-82375831 15853193350
Email: 1074800342@qq.com
Country: China
ProdList: 293
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Shanghai Hobor Chemical Co., Ltd

Tel: 21-21-61026752 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
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Aikon International Limited

Tel: 025-66028182 18112977050
Fax: (3)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 15820
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yxinchem

Tel: +86-0710-4323688 +86-18071785587
Fax: 15502706050
Email: market@yxinchem.com
Country: China
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BTC Pharmaceutical CO. Ltd

Tel: 0513-0513-68015-397-397 15716293042
Fax: 0513-68015394
Email: sales14@btcpharm.com
Country: China
ProdList: 644
Advantage: 55

Shanghai Taijilin Industrial Co., Ltd.

Tel: 021-021-50630626 18964684208
Fax: 021-50563898
Email: kate@tajilin.com
Country: China
ProdList: 1212
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QUALITY CONTROL SOLUTIONS LTD.

Tel: 0755-66853366 15920483169
Email: sales@chem-strong.com
Country: China
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Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 33001
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
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Country: China
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
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ProdList: 40241
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View Lastest Price from N-Benzyl-4-piperidone manufacturers

CONTIDE BIOTECH CO.,LTD

Product: N-benzyl-4-piperidone 3612-20-2
Price: US $0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 20
Release date: 2024-03-26

Shanghai Aosiris new Material Technology Co., LTD

Product: N-Benzyl-4-piperidone 3612-20-2
Price: US $3.00-1.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10 tons
Release date: 2024-03-11

hebei hongtan Biotechnology Co., Ltd

Product: 1-Benzyl-4-piperidone 3612-20-2
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 2000kg
Release date: 2024-03-18

3612-20-2, N-Benzyl-4-piperidoneRelated Search:

Benzoyl peroxide Haloperidol Benzyl chloride Benzyltriethylammonium chloride Benzyl alcohol Triacetonamine Benzyltrimethylammonium chloride 4-Amino-1-benzylpiperidine Benzyl acetate Benzyl benzoate DROPERIDOL 4-Benzylpiperidine 4,4-Piperidinediol hydrochloride 1-Methyl-4-piperidone 4-BENZYL-3-HYDROXYMETHYLMORPHOLINE BENZYL-(3-METHOXY-PHENYL)-AMINE 1-Benzyl-3-piperidinol N-benzyl-3-bromoaniline

NSC 77933

1-BENZYL-4-PIPERIDINONE FOR SYNTHESIS

[(4-Oxopiperidin-1-yl)methyl]benzene, 1-Benzyl-4-oxopiperidine

N- benzylpiperidineketone

1-Benzyl-4-piperidone, 99%, 99%

N - benzyl - 4 - piperidine ketone (3612-20-2)

N-BENZYL-4-PIPERIDONE

1-Benzylpiperidone

N-BENZYLPIPERIDONE

1-Benzyl-4-Pipridine

1-Benzylpiperid-4-one

1-Benzyl-4-Piperidone/1-Benzylpiperidone

N-Benzyl-4-Piperidone99%

1-Benzyl-4-piperidone, 98+%

1-Benzyl-4-piperidine

1-BENZYL-4-PIPERIDONE(N-BENZYL-4-PIPERIDONE)

1-Benzylpiperidin-4-one 96%

1-(Phenylmethyl)piperidin-4-one

N-Benzyl-4-oxopiperidine

1-Benzyl-1,2,5,6-tetrahydropyridine-4(3H)-one

Benzyl piperidone

4-Piperidone, 1-benzyl-

4-Piperidone,1-benzyl-

N-Benzyl-4-piperidinone

N-Benzyl-4-piperidon

N-Benzylpiperidin-4-one

N-Benzylpiperidinone

LABOTEST-BB LT00232987

BENZYL-4-PIPERIDONE

BENZYLPIPERIDONE-4

1-BENZYL-4-PIPERIDINONE

1-BENZYL-4-PIPERIDONE

1-BENZYL-4-OXOPIPERIDINE

1-BENZYLPIPERIDIN-4-ONE

1-(PHENYLMETHYL)-4-PIPERIDINONE

1-(PHENYLMETHYL)-4-PIPERIDONE

(4-Oxopiperidin-4-yl)methylbenzene

4-PIPERIDINONE, 1-(PHENYLMETHYL)-

N - benzyl - 4 - piperidine ketone (3612-

Irinotecan Impurity 30

N-BENZYL-4-PIPERIDONEBROMIDE

1-Benzyl-4-piperidone &gt

-4-piperidone

N-Benzyl-4-piperidone ISO 9001：2015 REACH

N-benzy-4-piperdone

N-benzy-4-piperdone powder

1-Benzy-4-piperidone(NBP)

Benzamide,7-bromo-

RSYY（Lifitegrast)-13

1-Benzy-4-piperidone

3612-20-2

3612-20-3

KETONE

Heterocyclic Building Blocks

Piperidones

Building Blocks

Piperidines, Piperidones, Piperazines

pharmacetical