Ethyl 1-benzylpiperidine-4-carboxylate
Uses Synthesis- Product Name
- Ethyl 1-benzylpiperidine-4-carboxylate
- CAS No.
- 24228-40-8
- Chemical Name
- Ethyl 1-benzylpiperidine-4-carboxylate
- Synonyms
- AKOS 225-01;BUTTPARK 33\04-91;RSYY（Avanafil)-28;RARECHEM AH CK 0037;SDCCGMLS-0066147.P001;Ethyl 1-Benzylisonipecotate;Ethyl N-benzylisonipecotate;1-benzyl-ethyl Isonipecotate;Ethyl N-benzylisonipecotinate;1-Benzyl-4-piperidinecarboxyli
- CBNumber
- CB4276544
- Molecular Formula
- C15H21NO2
- Formula Weight
- 247.33
- MOL File
- 24228-40-8.mol
Ethyl 1-benzylpiperidine-4-carboxylate Property
- Boiling point:
- 122°C (0.5 mmHg)
- Density
- 1.037 g/mL at 25 °C
- refractive index
- 1.5120-1.5160
- Flash point:
- >110℃
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Hexanes (Slightly), Methanol (Slightly)
- form
- clear liquid
- pka
- 7.93±0.10(Predicted)
- color
- Colorless to Light red
- InChI
- InChI=1S/C15H21NO2/c1-2-18-15(17)14-8-10-16(11-9-14)12-13-6-4-3-5-7-13/h3-7,14H,2,8-12H2,1H3
- InChIKey
- ASQCOPJFYLJCGD-UHFFFAOYSA-N
- SMILES
- N1(CC2=CC=CC=C2)CCC(C(OCC)=O)CC1
- CAS DataBase Reference
- 24228-40-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-25
- Safety Statements
- 24/25-45
- RIDADR
- UN 2810 6.1 / PGIII
- Hazard Note
- Irritant
- HS Code
- 29333990
N-Bromosuccinimide Price
- Product number
- E0862
- Product name
- Ethyl 1-Benzyl-4-piperidinecarboxylate
- Purity
- >95.0%(GC)(T)
- Packaging
- 5g
- Price
- $57
- Updated
- 2023/06/20
- Product number
- E0862
- Product name
- Ethyl 1-Benzyl-4-piperidinecarboxylate
- Purity
- >95.0%(GC)(T)
- Packaging
- 25g
- Price
- $203
- Updated
- 2021/12/16
- Product number
- B233660
- Product name
- N-Benzyl-4-carboethoxypiperidine
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- B233660
- Product name
- N-Benzyl-4-carboethoxypiperidine
- Packaging
- 10g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- M386
- Product name
- Ethyl1-benzylpiperidine-4-carboxylate
- Packaging
- 5g
- Price
- $11
- Updated
- 2021/12/16
Ethyl 1-benzylpiperidine-4-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 1-benzyl-4-piperidinecarboxylate and its derivatives are important pharmaceutical intermediates with high biological activity. Ethyl 1-benzyl-4-piperidinecarboxylate can be used to synthesize anti-inflammatory drug trypsin inhibitors, antagonizing inflammatory mediators at the receptor level. It can also be used to synthesize antitumor drugs such as matrix metalloproteinase inhibitors and farnesyltransferase inhibitors. In summary, ethyl 1-benzyl-4-piperidinecarboxylate and its derivatives possess excellent biological activity and can be used not only to synthesize GABA uptake inhibitors and antitumor drugs, but also to synthesize growth hormone secretagogues, anti-inflammatory and analgesic drugs, cardiovascular drugs, nootropic drugs, antiviral drugs, and bone disease drugs.
Synthesis
Ethyl isonipecotate (50 g, 0.31 mol) was dissolved in toluene (150 mL) in a round
bottom flask, charged with potassium carbonate (60 g, 0.43
mol) and stirred for 15 min. Benzyl chloride (42 g, 0.31 mol)
was charged and the reaction mass was refluxed for 4 h at
100 °C. Upon completion of the reaction as marked by TLC
(hexane:ethyl acetate; 2:1), the reaction mass was cooled to
room temperature and quenched with water (100 mL), stirred
and the organic phase was separated. The aqueous phase was
again extracted with toluene (100 mL). Combined organic
phase was washed twice with saturated brine solution (50 mL).
Remove toluene in vacuo to obtain Ethyl N-benzylpiperidine-4-carboxylate
( 6.97 g, 91 %) as a yellow liquid.
Chemical Properties
Colourless Oil
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 22, p. 6938 - 6942,5
[2] Journal of medicinal chemistry, 1980, vol. 23, # 8, p. 848 - 851
[3] Patent: WO2010/12611, 2010, A1. Location in patent: Page/Page column 28
[4] Journal of Medicinal Chemistry, 1996, vol. 39, # 3, p. 749 - 756
[5] Organic Preparations and Procedures International, 1994, vol. 26, # 3, p. 421 - 428
Ethyl 1-benzylpiperidine-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 1-benzylpiperidine-4-carboxylate Suppliers
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View Lastest Price from Ethyl 1-benzylpiperidine-4-carboxylate manufacturers
- Product
- Ethyl 1-benzylpiperidine-4-carboxylate 24228-40-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
- Product
- Ethyl 1-benzylpiperidine-4-carboxylate 24228-40-8
- Price
- US $10.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 Metric Ton/Month
- Release date
- 2024-03-20
- Product
- Ethyl N-benzyl piperidine-4-carboxylate 24228-40-8
- Price
- US $100.00/bag
- Min. Order
- 1bag
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2023-09-11