Ethyl 1-methyl-4-piperidinecarboxylate

Product Name: Ethyl 1-methyl-4-piperidinecarboxylate
CAS No.: 24252-37-7
Chemical Name: Ethyl 1-methyl-4-piperidinecarboxylate
Synonyms: Ethyl N-methylisonipecotate;N-Methyl ethyl isonipecotate;ETHYL 1-METHYLPIPERIDINE-4-CARBOXYLATE;ETHYL 1-METHYL-4-PIPERIDINECARBOXYLATE;Ethyl N-Methyl piperidine-4-carboxylate;Ethyl 1-methylpiperidine-4-carboxylate 97%;Ethyl 1-Methylpiperidine-4-carboxylate, 97+%;Ethyl 1-methylpiperidine-4-carboxylate, 96%,;1-methyl-4-piperidinecarboxylic acid ethyl ester;1-Methyl-piperidin-4-carboxylic acid ethyl ester
CBNumber: CB7715550
Molecular Formula: C9H17NO2
Formula Weight: 171.24
MOL File: 24252-37-7.mol

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Ethyl 1-methyl-4-piperidinecarboxylate Property

Boiling point:: 94-95 °C(Press: 12 Torr)
Density: 0.963 g/mL at 25 °C
refractive index: n20/D1.450
Flash point:: 87℃
storage temp.: Sealed in dry,Room Temperature
form: liquid
pka: 8.50±0.10(Predicted)
Appearance: Colorless to light yellow Liquid
CAS DataBase Reference: 24252-37-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-36/37/39
RIDADR: NA 1993 / PGIII
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 724165
Product name: Ethyl 1-methylpiperidine-4-carboxylate
Purity: 97%
Packaging: 1g
Price: $85
Updated: 2023/01/07

TRC

Product number: E925578
Product name: Ethyl 1-methylpiperidine-4-carboxylate
Packaging: 25g
Price: $145
Updated: 2021/12/16

Matrix Scientific

Product number: 074992
Product name: Ethyl 1-methylpiperidine-4-carboxylate
Purity: 95+%
Packaging: 5g
Price: $200
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-14
Product name: Ethyl 1-methylpiperidine-4-carboxylate
Packaging: 5G
Price: $225
Updated: 2021/12/16

Matrix Scientific

Product number: 074992
Product name: Ethyl 1-methylpiperidine-4-carboxylate
Purity: 95+%
Packaging: 10g
Price: $286
Updated: 2021/12/16

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Ethyl 1-methyl-4-piperidinecarboxylate Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

Reactant for synthesis of:

Piperidine derivatives as inhibitors of S. aureus and E. coli enoyl-ACP reductase
GABAA receptor agonists
Water-soluble DNA-binding subunits for analogues of cytotoxic antibiotic CC-1065 and their prodrugs
Tricyclic pharmaceuticals
5-HT3 antagonists

Synthesis

1126-09-6

50-00-0

24252-37-7

Example 22 Synthesis of ethyl 1-methylpiperidine-4-carboxylate (21): ethyl 4-piperidinecarboxylate (20) (5.00 g, 31.8 mmol) was dissolved in an ice-cold mixture of glacial acetic acid (3.80 g, 63.6 mmol) and water (11 mL). Subsequently, 37% formaldehyde aqueous solution (2.85 mL, 38.2 mmol) was added to the solution and hydrogenation reaction was carried out in the presence of Pd/C (10%, 338 mg) catalyst for 3.5 hours at room temperature and 58 psi H2 pressure. Upon completion of the reaction, the solid catalyst was removed by diatomaceous earth filtration and the filter cake was washed thoroughly with deionized water (50 mL). The filtrate was adjusted to pH 11 with 1 M NaOH solution under cooling in an ice bath. after adjusting the pH, multiple extractions were carried out with ether (5 x 100 mL) and the organic phases were combined and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give the product 21 (5.44 g, quantitative yield) in the form of a colorless liquid, which could be used in the next reaction without further purification. The product characterization data were as follows: 1H NMR (300 MHz, CDCl3): δ=1.25 (t, J=7.1 Hz, 3H, OCH2CH3), 1.69-2.06 (m, 6H, 2-Hax, 3-H2, 5-H2, 6-Hax), 2.18-2.32 (m, 1H, 4-H), 2.27 (s, 3H, NMe) , 2.75-2.87 (m, 2H, 2-Heq, 6-Heq), 4.13 (q, J=7.1Hz, 2H, OCH2CH3) ppm. 13C NMR (75.5MHz, CDCl3): δ=14.1 (OCH2CH3), 28.2 (C-3, C-5), 40.5 (C-4), 46.3 (NMe) , 54.9 (C-2, C-6), 60.2 (OCH2CH3), 175.0 (C=O) ppm. MS (70eV, EI): m/z (%) = 171 (31) [M]+, 142 (59) [M-CH2CH3]+, 126 (40) [M-OCH2CH3]+, 98 (56) [M-CO2Et]+. Molecular formula: C9H17NO2 (molecular weight: 171.24).

References

[1] European Journal of Organic Chemistry, 2006, # 10, p. 2314 - 2321
[2] Patent: US2009/318668, 2009, A1. Location in patent: Page/Page column 52
[3] Patent: WO2007/89149, 2007, A2. Location in patent: Page/Page column 96
[4] Patent: US2011/9390, 2011, A1. Location in patent: Page/Page column 13-14
[5] European Journal of Medicinal Chemistry, 1994, vol. 29, # 1, p. 115 - 120

Ethyl 1-methyl-4-piperidinecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 1-methyl-4-piperidinecarboxylate Suppliers

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View Lastest Price from Ethyl 1-methyl-4-piperidinecarboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl 1-methylpiperidine-4-carboxylate 24252-37-7
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Wuhan Xinhao Biotechnology Co., Ltd

Product: Ethyl 1-methyl-4-piperidinecarboxylate 24252-37-7
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Metric Ton/Month
Release date: 2024-03-11

Jinan Ande Pharmaceutical Co.,Ltd.

Product: Ethyl 1-methyl-4-piperidinecarboxylate 24252-37-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000
Release date: 2021-12-23

24252-37-7, Ethyl 1-methyl-4-piperidinecarboxylateRelated Search:

Kresoxim-methyl Isonipecotic acid Bensulfuron methyl Methylparaben Methyl acetate Methyl acrylate 2,2,6,6-Tetramethyl-4-piperidinol Ethyl formate Triacetonediamine Ethyl nipecotate Ethyl 4-piperidinecarboxylate METSULFURON METHYL Urethane 1,2,2,6,6-Pentamethyl-4-piperidinol 1-Methyl-4-piperidone Ethyl 1-methylnipecotate Thiophanate-methyl Methyl

ETHYL 1-METHYLPIPERIDINE-4-CARBOXYLATE

1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER

ETHYL 1-METHYL-4-PIPERIDINECARBOXYLATE

N-Methyl ethyl isonipecotate

REF DUPL: 1-Methyl-piperidine-4-carboxylic acid ethyl ester

Ethyl N-Methyl piperidine-4-carboxylate

Ethyl 1-methylisonipecotate, 4-(Ethoxycarbonyl)-1-methylpiperidine

Ethyl 1-Methylpiperidine-4-carboxylate, 97+%

Ethyl N-methylisonipecotate

1-methyl-4-piperidinecarboxylic acid ethyl ester

Ethyl 1-methyl-4-piperidinecarboxylate CAS 24252-37-7

Ethyl 1-methylpiperidine-4-carboxylate 97%

Ethyl 1-methylpiperidine-4-carboxylate, 96%,

1-Methyl-piperidin-4-carboxylic acid ethyl ester

24252-37-7

Heterocyclic Compounds