Ethyl 1-methylnipecotate
- Product Name
- Ethyl 1-methylnipecotate
- CAS No.
- 5166-67-6
- Chemical Name
- Ethyl 1-methylnipecotate
- Synonyms
- NSC 64739;LABOTEST-BB LT00159658;ETHYL 1-METHYLNIPECOTATE;Ethyl 1-methylnipecotate, 98+%;1-Methyl-nipecotic acid ethyl ester;Ethyl-1-methylpiperidin-3-carboxylat;Ethyl N-Methylpiperidine-3-carboxylate;ETHYL 1-METHYLPIPERIDINE-3-CARBOXYLATE;thyl N-methyl piperidine-3-carboxylate;ETHYL 1-METHYL-3-PIPERIDINE-CARBOXYLATE
- CBNumber
- CB8289450
- Molecular Formula
- C9H17NO2
- Formula Weight
- 171.24
- MOL File
- 5166-67-6.mol
Ethyl 1-methylnipecotate Property
- Boiling point:
- 88-89 °C/11 mmHg (lit.)
- Density
- 0.954 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.451(lit.)
- Flash point:
- 155 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- 8.56±0.10(Predicted)
- color
- Colorless to Almost colorless
- BRN
- 123259
- InChI
- 1S/C9H17NO2/c1-3-12-9(11)8-5-4-6-10(2)7-8/h8H,3-7H2,1-2H3
- InChIKey
- VFJJNMLPRDRTCO-UHFFFAOYSA-N
- SMILES
- CCOC(=O)C1CCCN(C)C1
- CAS DataBase Reference
- 5166-67-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethyl 1-methylnipecotate(5166-67-6)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-37/39
- WGK Germany
- 3
- F
- 9-23
- Hazard Note
- Irritant
- HS Code
- 29333990
- Storage Class
- 10 - Combustible liquids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 194352
- Product name
- Ethyl 1-methyl-3-piperidinecarboxylate
- Purity
- 96%
- Packaging
- 5g
- Price
- $92.4
- Updated
- 2023/06/20
- Product number
- E0863
- Product name
- Ethyl 1-Methyl-3-piperidinecarboxylate
- Purity
- >95.0%(GC)(T)
- Packaging
- 5g
- Price
- $51
- Updated
- 2025/07/31
- Product number
- E0863
- Product name
- Ethyl 1-Methyl-3-piperidinecarboxylate
- Purity
- >95.0%(GC)(T)
- Packaging
- 25g
- Price
- $140
- Updated
- 2025/07/31
- Product number
- E926783
- Product name
- Ethyl1-Methylpiperidine-3-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 43446
- Product name
- Ethyl1-methyl-3-piperidinecarboxylate,≥95%(GC)
- Purity
- ≥95%(GC)
- Packaging
- 5G
- Price
- $46.22
- Updated
- 2021/12/16
Ethyl 1-methylnipecotate Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to pale yellow liquid
Uses
Reactant for:
N-demethylation of tertiary amines
Reverse cope elimination reactions
Regioselective oxidation
Synthesis of chelating agents
Sequential Michael-Michael-Dieckmann cyclizations
General Description
Enantiomeric discrimination has been investigated in 1H and 13C NMR spectra of ethyl 1-methyl-3-piperidinecarboxylate in the presence of (-)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.
Synthesis
122-51-0
71962-74-8
5166-67-6
The general procedure for the synthesis of ethyl 1-methyl-3-piperidinecarboxylate from triethyl orthoformate and ethyl crotonate is as follows: in an autoclave, a 1 molar concentration of catalyst based on the molar amount of amine is added, and after displacing the air in the autoclave with argon, 0.1 moles of amine and 0.11-0.3 moles of o-carboxylic acid ester dissolved in a 10 ml solution in methanol (or ethanol) are added, as well as 0.5 ml of 0.2 M anhydrous p-toluene benzenesulfonic acid solution in methanol (or ethanol). The reaction mixture was heated to 120°C and charged with hydrogen gas to a pressure of 40 bar. The reaction mixture was stirred continuously at a constant pressure until the absorption of hydrogen ceased (reaction time of about 0.2-6 hours). After completion of the reaction, the catalyst was removed by filtration and the filtrate was distilled to purify the target product.
References
[1] Patent: WO2017/133913, 2017, A1. Location in patent: Page/Page column 9; 14
Ethyl 1-methylnipecotate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 1-methylnipecotate manufacturers
- Product
- Ethyl 1-methylnipecotate 5166-67-6
- Price
- US $10.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 Metric Ton/Month
- Release date
- 2024-03-20
- Product
- thyl N-methyl piperidine-3-carboxylate 5166-67-6
- Price
- US $100.00/bag
- Min. Order
- 1bag
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2023-09-11
- Product
- Ethyl-1-methylpiperidin-3-carboxylat 5166-67-6
- Price
- US $10.00-15.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 2546245
- Release date
- 2022-09-23