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DIPHENOXYLATE HYDROCHLORIDE

Product Name
DIPHENOXYLATE HYDROCHLORIDE
CAS No.
3810-80-8
Chemical Name
DIPHENOXYLATE HYDROCHLORIDE
Synonyms
DIPHENOXYLATE HCL;r1132;DIPHENOXYLATE HYDROCHLORIDE;Diphenoxylate hydrochloride solution;Diphenoxylate for system suitability;Diphenoxylate Hydrochloride CII (200 mg);Diphenoxylate HCL (Subj To Narcotic Permit);DIPHENOXYLATE HYDROCHLORIDE METHANOL SOL UTION;DIPHENOXYLATE HYDROCHLORIDE ANTIPERISTAL TIC, ANTI;Diphenoxylate Hydrochloride (1.0 mg/ml in Methanol)
CBNumber
CB6305387
Molecular Formula
C30H33ClN2O2
Formula Weight
489.05
MOL File
3810-80-8.mol
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DIPHENOXYLATE HYDROCHLORIDE Property

Melting point:
220.5-222°
storage temp. 
-20°C
solubility 
Very slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
form 
Solid
color 
White to Off-White
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Safety

RIDADR 
1544
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2933330000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1219008
Product name
Diphenoxylate for system suitability
Packaging
200mg
Price
$581
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
CHM0152896
Product name
DIPHENOXYLATE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$774.4
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0152896
Product name
DIPHENOXYLATE HYDROCHLORIDE
Purity
95.00%
Packaging
50MG
Price
$1871.1
Updated
2021/12/16
Chemtos
Product number
D-2506
Product name
DiphenoxylateHCl
Packaging
10mg
Price
$1200
Updated
2021/12/16
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DIPHENOXYLATE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Originator

Lomotil,Searle,US,1960

Uses

Antiperistaltic; antidiarrheal. Controlled substance (opiate).

Definition

ChEBI: The hydrochloride salt of diphenoxylate.

Manufacturing Process

A mixture of 23 parts of the ethyl ester of 4-phenylisonipecotic acid and 15 parts of 2,2-diphenyl-4-
omobutyronitrile in 19 parts of xylene is heated for 24 hours at 100-120°C and then cooled and filtered to remove the precipitate of the hydro
omide of the ethyl ester of 4-phenylisonipecotic acid. The filtrate is then extracted with dilute hydrochloric acid and the extract is rendered alkaline by addition of concentrated aqueous potassium hydroxide and extracted with ether. This ether extract is treated with gaseous hydrogen chloride. The resulting precipitate is collected on a filter. The hydrochloride of the ethyl ester of 2,2-diphenyl-4-(4'-carboxy-4'-phenyl-1'- piperidino)butyronitrile thus obtained melts at about 220.5-222°C. See meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl ester.

Therapeutic Function

Antidiarrheal

Veterinary Drugs and Treatments

Diphenoxylate is an opiate in combination with atropine in antidiarrheal products used primarily in dogs; it also has antitussive properties. Use in cats is controversial and many clinicians do not recommend its use in this species.

DIPHENOXYLATE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIPHENOXYLATE HYDROCHLORIDE Suppliers

Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29810
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Zhuhai Anzhe Biotechnology Co,Ltd.
Tel
13169972583
Email
513211116@qq.com
Country
China
ProdList
3006
Advantage
58
LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
15583
Advantage
58
CHANG ZHOU A SANG QI TECHNOLOGY CO.,LTD
Tel
18961267976
Email
1184262569@qq.com
Country
China
ProdList
498
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
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View Lastest Price from DIPHENOXYLATE HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
:DIPHENOXYLATE HYDROCHLORIDE 3810-80-8
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-20

3810-80-8, DIPHENOXYLATE HYDROCHLORIDERelated Search:


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  • Diphenoxylate hydrochloride solution
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  • isonipecoticacid,1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-,ethylester,hydro
  • r1132
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  • Diphenoxylate Hydrochloride CII (200 mg)
  • Diphenoxylate Hydrochloride CII (200 mg)I1D3390.998mg/mg(dr)
  • DIPHENOXYLATE HYDROCHLORIDE METHANOL SOL UTION
  • DIPHENOXYLATE HYDROCHLORIDE ANTIPERISTAL TIC, ANTI
  • Diphenoxylate Hydrochloride (1.0 mg/ml in Methanol)
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