N-Boc-piperidine-3-methanol

Product Name: N-Boc-piperidine-3-methanol
CAS No.: 116574-71-1
Chemical Name: N-Boc-piperidine-3-methanol
Synonyms: TERT-BUTYL 3-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;CAS:116574-71-1;N-BOC-(3S)-PIP(3-CH2OH);1-Boc-3-piperidinemethanol;N-Boc-3-piperidinecarbinol;N-Boc-piperidine-3-methanol;N-Boc-piperidine-5-Methanol;N-Boc-piperidine-6-Methanol;N-Boc-piperidine-7-Methanol;N-Boc-piperidine-8-Methanol
CBNumber: CB7157299
Molecular Formula: C11H21NO3
Formula Weight: 215.29
MOL File: 116574-71-1.mol

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N-Boc-piperidine-3-methanol Property

Melting point:: 77-81 °C
Boiling point:: 308.0±15.0 °C(Predicted)
Density: 1.059±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in methanol and dimethylformamide(DMF).
form: powder to crystal
pka: 14.93±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h9,13H,4-8H2,1-3H3
InChIKey: OJCLHERKFHHUTB-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCCC(CO)C1
CAS DataBase Reference: 116574-71-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 681318
Product name: N-Boc-piperidine-3-methanol
Purity: 97%
Packaging: 1g
Price: $31.2
Updated: 2023/06/20

Sigma-Aldrich

Product number: 681318
Product name: N-Boc-piperidine-3-methanol
Purity: 97%
Packaging: 10g
Price: $297
Updated: 2023/06/20

TCI Chemical

Product number: B3787
Product name: 1-(tert-Butoxycarbonyl)-3-piperidinemethanol
Purity: >95.0%(GC)
Packaging: 5g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: B3787
Product name: 1-(tert-Butoxycarbonyl)-3-piperidinemethanol
Purity: >95.0%(GC)
Packaging: 25g
Price: $139
Updated: 2024/03/01

TRC

Product number: H972983
Product name: tert-Butyl3-(Hydroxymethyl)piperidine-1-carboxylate
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

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N-Boc-piperidine-3-methanol Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

(+/-)-1-Boc-3-(hydroxymethyl)piperidine is used as a reactant for synthesis of Pim-1 inhibitors, Vasopressin1b receptor antagonists, CXCR4 antagonists as anti-HIV agents, Amide CCR5 antagonist, PSSRI-based inhibitors of S. aureus multidrug efflux pumps and Human GnRH receptor antagonists.

Uses

Reactant for synthesis of:

Pim-1 inhibitors
Vasopressin1b receptor antagonists
CXCR4 antagonists as anti-HIV agents
Amide CCR5 antagonist
PSSRI-based inhibitors of S. aureus multidrug efflux pumps
Human GnRH receptor antagonists

Synthesis

4606-65-9

24424-99-5

116574-71-1

(1) Preparation of 3-(hydroxymethyl)-1-(tert-butoxycarbonyl)piperidine: To a solution of 3-hydroxymethylpiperidine (1.15 g, 10 mmol) in tetrahydrofuran (15 ml) was added triethylamine (2.8 ml, 20 mmol) at room temperature. Subsequently, a solution of di-tert-butyl dicarbonate (2.62 g, 10 mmol) in tetrahydrofuran (5 ml) was added slowly and dropwise with stirring. The reaction mixture was stirred continuously for 20 hours at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (50 ml), and the organic phase was washed sequentially with water and saturated saline, and then dried with anhydrous sodium sulfate. Finally, the solvent was removed by reduced pressure distillation to afford the target product tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate (2.15 g, 100% yield) as colorless crystals. The product was confirmed by 1H-NMR (CDCl3) and IR (KBr) characterization.1H-NMR (CDCl3) δ: 1.2-1.4 (2H, m), 1.46 (9H, s), 1.5-1.9 (4H, m), 2.8-3.3 (2H, m), 3.51 (2H, t, J = 6.10 Hz), 3.6-3.9 (2H, m) IR (KBr) cm-1: 3491, 1742, 1674, 1428, 1269, 1177, 1153, 858, 769.

References

[1] Patent: US6348468, 2002, B1. Location in patent: Page column 49
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 4, p. 1084 - 1088
[3] Patent: US2004/67935, 2004, A1. Location in patent: Page/Page column 28
[4] Patent: US2002/65265, 2002, A1
[5] Patent: WO2004/72086, 2004, A2. Location in patent: Page 170

N-Boc-piperidine-3-methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-piperidine-3-methanol Suppliers

Americas 1 China 246 Europe 1 Germany 3 India 7 Japan 2 Russia 1 Switzerland 3 Ukraine 1 United Kingdom 9 United States 46 Global 320

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View Lastest Price from N-Boc-piperidine-3-methanol manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: N-Boc-piperidine-3-methanol 116574-71-1
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-10-15

Anhui Zhongda Biotechnology Co., Ltd

Product: Pharmaceutical Intermediates 116574-71-1
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100tons
Release date: 2023-10-24

Hebei Mingeng Biotechnology Co., Ltd

Product: 1-Boc-3-piperidinemethanol 116574-71-1
Price: US $200.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 500kg/month
Release date: 2022-05-06

116574-71-1, N-Boc-piperidine-3-methanolRelated Search:

n-boc-piperidine-2-methanol,1-Boc-Piperidine-2-Methanol N-Boc-4-piperidinemethanol 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE N-BOC-3-Aminopiperidine 1-BOC-3-PIPERIDINECARBOXALDEHYDE (+/-)-1-N-BOC-PIPERIDINE-2-CARBOXAMIDE 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde N-BOC-piperidine-4-carboxylic acid N-Boc-2-piperidinecarboxylic acid Ethyl N-Boc-piperidine-4-carboxylate Ethyl 1-Boc-piperidine-2-carboxylate 1-Boc-3-hydroxypiperidine N-Boc-Piperidine-4-carboxylic acid methyl ester TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE 1-Boc-4-Methylaminopiperidine 1-N-BOC-PIPERIDINE-3-CARBOXAMIDE 1-Boc-3-piperidone N-(tert-Butoxycarbonyl)-4-piperidone

(+/-)-BOC-3-PIPERIDINE METHANOL

N-(TERT-BUTOXYCARBONYL)-3-PIPERIDINEMETHANOL

N-BOC-(3S)-PIP(3-CH2OH)

N-BOC-3-HYDROXYMETHYLPIPERIDINE

(+/-)-N-BOC-3-PIPERIDINE METHANOL

N-BOC-3-PIPERIDINYL-METHANOL

N-Boc-piperidine-3-methanol

TERT-BUTYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

TERT-BUTYL 3-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE

(S)-TERT-BUTYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

(S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYMETHYLPIPERIDINE

(S)-1-BOC-3-(HYDROXYMETHYL)PIPERIDINE

(S)-1-N-BOC-3-HYDROXYMETHYL-PIPERIDINE

1-Boc-3-(hydroxymethyl)pi...

3-(Hydroxymethyl)piperidine, N-BOC protected

N-Boc-piperidine-5-Methanol

1-N-Boc-3-(hydroxymethyl)piperidine

1-Boc-3-piperidinemethanol

1-BOC-3-(HYROXYMETHYL)PIPERIDINE

1-TERT-BUTOXYCARBONYL-3-PIPERIDINEMETHANOL, N-BOC-3-PIPERIDINEMETHANOL

1-Piperidinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester

N-Boc-piperidine-6-Methanol

N-Boc-piperidine-7-Methanol

3-(S)-N-BOC-PIPERIDINE METHANOL

3-HYDROXYMETHYL-1-N-BOC-PIPERIDINE

3-HYDROXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-BOC-3-(HYDROXYMETHYL)PIPERIDINE

N-Boc-piperidine-8-Methanol

1,1-Dimethylethyl 3-(hydroxymethyl)-1-piperidinecarboxylate

3-(Hydroxymethyl)-N-(tert-butoxycarbonyl)piperidine

1-Boc-3-(hydroxymethyl)piperidine 1-Boc-3-piperidinemethanol 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperidine

1-N-Boc-3-(S)-Methanol-piperidine

N-Boc-3-PiperidineMethanol or N-tert-Butyloxycarbonyl-3-piperidineMethanol or N-Boc-3-(hydroxyMethyl)piperidine

tert-Btuyl 3-(hydroxymethyl)piperidine-1-carboxylate

<i>N</i>-Boc-piperidine-3-methanol

N-Boc-piperidine-3-methanol 97%

(^+)-1-Boc-3-(hydroxymethyl)piperidine,97%

1-(tert-Butoxycarbonyl)-3-piperidinemethanol &gt

N-Boc-3-piperidinyl alcohol

1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperidine

3-(hydroxymethyl)piperidine-1-carboxylate

CAS:116574-71-1

N-Boc-3-piperidinecarbinol

116574-71-1

116574-71-6

116574-71-5

116574-71-4

116574-71-3

116574-74-1

C11H21NO3

Building Blocks

C11

Chemical Synthesis

Heterocyclic Building Blocks

Piperidines

Heterocyclic Compounds

pharmacetical

Piperidine