1-BOC-3-PIPERIDINECARBOXALDEHYDE

Product Name: 1-BOC-3-PIPERIDINECARBOXALDEHYDE
CAS No.: 118156-93-7
Chemical Name: 1-BOC-3-PIPERIDINECARBOXALDEHYDE
Synonyms: tert-butyl 3-formylpiperidine-1-carboxylate;CAS:118156-93-7;BUTTPARK 147\06-01;1-BOC-3-PIPERIDINECA;1-BOC-3-PIPERIDINECAR;1-Boc-3-formylpiperidine;N-BOC-3-FORMYLPIPERIDINE;3-ForMyl-N-BOCpiperidine;1-N-BOC-3-FORMYLPIPERIDINE;1-Boc-3-ForMyl-piperidine 97%
CBNumber: CB1362192
Molecular Formula: C11H19NO3
Formula Weight: 213.27
MOL File: 118156-93-7.mol

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1-BOC-3-PIPERIDINECARBOXALDEHYDE Property

Boiling point:: 295.4±33.0 °C(Predicted)
Density: 1.114±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: liquid
pka: -2.29±0.40(Predicted)
color: Clear, light yellow
Sensitive: Air Sensitive
InChI: InChI=1S/C11H19NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h8-9H,4-7H2,1-3H3
InChIKey: CTVHINDANRPFIL-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCCC(C=O)C1
CAS DataBase Reference: 118156-93-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N,Xn
Risk Statements: 36/37/38-50-36-22
Safety Statements: 26-36/37/39-61-37
RIDADR: UN3077
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B695105
Product name: tert-Butyl3-Formylpiperidine-1-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 069307
Product name: 3-Formyl-N-(tert-butoxycarbonyl)piperidine
Purity: >95%
Packaging: 1g
Price: $20
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK441378
Product name: 1-Boc-3-piperidinecarboxaldehyde
Purity: 97%
Packaging: 250mg
Price: $43
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139948
Product name: tert-Butyl 3-formylpiperidine-1-carboxylate
Packaging: 1g
Price: $50
Updated: 2021/12/16

Apolloscientific

Product number: OR15677
Product name: Piperidine-3-carboxaldehyde, N-BOC protected
Purity: 98%
Packaging: 5g
Price: $57
Updated: 2021/12/16

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1-BOC-3-PIPERIDINECARBOXALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

1-Boc-piperidine-3-carboxaldehyde is used as an organic chemical synthesis intermediate.

Synthesis

116574-71-1

118156-93-7

General procedure for the synthesis of 1-Boc-3-piperidinecarboxaldehyde from tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate: a solution of dimethylsulfoxide (DMSO, 0.18 mL, 2.6 mmol) in dichloromethane (CH2Cl2, 5 mL) was slowly added dropwise at -78 °C to a solution of oxalyl chloride (2 M in CH2Cl2, 0.65 mL, 1.3 mmol ) in a solution of methylene chloride (4 mL). The reaction mixture was stirred at -68 °C for 15 min. Subsequently, tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate (0.22 g, 1.0 mmol) was added dropwise to a dichloromethane (4 mL) solution. After continued stirring at -78 °C for 15 min, triethylamine (Et3N, 6 mL) was added. The reaction mixture was warmed to room temperature and stirred for 16 hours. Upon completion of the reaction, water was added to quench the reaction and the mixture was extracted with ether. The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the yellow oily product 1-Boc-3-piperidinecarboxaldehyde (0.20 g, 92% yield). The crude product could be directly used in the subsequent reaction without further purification. Mass spectrum (ESI) m/z 214 (M + 1).

References

[1] Patent: WO2006/62465, 2006, A1. Location in patent: Page/Page column 40
[2] Patent: US2004/229864, 2004, A1. Location in patent: Page/Page column 11
[3] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0560-0561
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 4, p. 1368 - 1373
[5] Patent: US2014/31354, 2014, A1. Location in patent: Paragraph 0421; 0422

1-BOC-3-PIPERIDINECARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-3-PIPERIDINECARBOXALDEHYDE Suppliers

China 182 France 1 Germany 1 India 4 United Kingdom 5 United States 35 Global 228

Shanghai Hobor Chemical Co., Ltd

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Pure Chemistry Scientific Inc.

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View Lastest Price from 1-BOC-3-PIPERIDINECARBOXALDEHYDE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: N-BOC-3-piperidine carboxyaldehyde 118156-93-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Wuhan Xinhao Biotechnology Co., Ltd

Product: 1-BOC-3-PIPERIDINECARBOXALDEHYDE 118156-93-7
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Metric Ton/Month
Release date: 2024-03-19

Hebei Mingeng Biotechnology Co., Ltd

Product: 1-Boc-3-Formylpiperidine 118156-93-7
Price: US $200.00/KG
Min. Order: 10g
Purity: 99%
Supply Ability: 500kg/month
Release date: 2021-12-17

118156-93-7, 1-BOC-3-PIPERIDINECARBOXALDEHYDERelated Search:

1-N-Boc-2-piperidinecarboxaldehyde,1-Boc-2-Piperidinecarboxaldehyde 1-BOC-4-PIPERIDINECARBOXALDEHYDE,1-N-Boc-4-piperidinecarboxaldehyde 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE N-BOC-3-Aminopiperidine N-Boc-4-piperidinemethanol (+/-)-1-N-BOC-PIPERIDINE-2-CARBOXAMIDE N-BOC-piperidine-4-carboxylic acid N-Boc-2-piperidinecarboxylic acid Ethyl N-Boc-piperidine-4-carboxylate Ethyl 1-Boc-piperidine-2-carboxylate 1-Boc-3-hydroxypiperidine N-Boc-Piperidine-4-carboxylic acid methyl ester N-Boc-piperidine-3-methanol N-Boc-piperidine-2-methanol TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE 1-Boc-4-Methylaminopiperidine 1-N-BOC-PIPERIDINE-3-CARBOXAMIDE 1-Boc-3-piperidone

N-BOC-3-PIPERIDINYLCARBOXALDEHYDE

N-BOC-3-FORMYLPIPERIDINE

BOC-3-PIPERIDINECARBOXALDEHYDE

BUTTPARK 147\06-01

1-BOC-3-PIPERIDINECARBOXALDEHYDE

1-N-BOC-3-FORMYLPIPERIDINE

3-FORMYLPIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-Piperidinecarboxylic acid, 3-formyl-, 1,1-dimethylethyl ester

Piperidine-3-carboxaldehyde, N-BOC protected

N-Boc-3-piperidinecarboxaldehyde

1-Boc-3-formylpiperidine

Piperidine-3-carboxaldehyde, N-BOC protected 98%

tert-butyl 3-formylpiperidine-1-carboxylate

1-Boc-piperidine-3-carboxaldehyde

tert-Butyl 3-formylpiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-formylpiperidine

3-FORMYLPIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ES

3-ForMyl-N-BOCpiperidine

1-Boc-3-ForMyl-piperidine 97%

N-BOC-3-piperidine carboxyaldehyde

1-BOC-3-PIPERIDINECA

1-BOC-3-PIPERIDINECAR

3-Formyl-N-(tert-butoxycarbonyl)piperidine

N-boc -3- piperidine carboxylaldehyde

TIANFUCHEM--118156-93-7-- 1-BOC-3-PIPERIDINECARBOXALDEHYDE factory price

CAS:118156-93-7

118156-93-7

pharmacetical

Piperidine