ChemicalBook > CAS DataBase List > 1-BOC-3-PIPERIDINECARBOXALDEHYDE

1-BOC-3-PIPERIDINECARBOXALDEHYDE

Product Name
1-BOC-3-PIPERIDINECARBOXALDEHYDE
CAS No.
118156-93-7
Chemical Name
1-BOC-3-PIPERIDINECARBOXALDEHYDE
Synonyms
tert-butyl 3-formylpiperidine-1-carboxylate;CAS:118156-93-7;BUTTPARK 147\06-01;1-BOC-3-PIPERIDINECA;1-BOC-3-PIPERIDINECAR;1-Boc-3-formylpiperidine;N-BOC-3-FORMYLPIPERIDINE;3-ForMyl-N-BOCpiperidine;1-N-BOC-3-FORMYLPIPERIDINE;1-Boc-3-ForMyl-piperidine 97%
CBNumber
CB1362192
Molecular Formula
C11H19NO3
Formula Weight
213.27
MOL File
118156-93-7.mol
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1-BOC-3-PIPERIDINECARBOXALDEHYDE Property

Boiling point:
295.4±33.0 °C(Predicted)
Density 
1.114±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
liquid
pka
-2.29±0.40(Predicted)
color 
Clear, light yellow
Sensitive 
Air Sensitive
InChI
InChI=1S/C11H19NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h8-9H,4-7H2,1-3H3
InChIKey
CTVHINDANRPFIL-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCCC(C=O)C1
CAS DataBase Reference
118156-93-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,N,Xn
Risk Statements 
36/37/38-50-36-22
Safety Statements 
26-36/37/39-61-37
RIDADR 
UN3077
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B695105
Product name
tert-Butyl3-Formylpiperidine-1-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
069307
Product name
3-Formyl-N-(tert-butoxycarbonyl)piperidine
Purity
>95%
Packaging
5g
Price
$68
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139948
Product name
tert-Butyl 3-formylpiperidine-1-carboxylate
Packaging
2g
Price
$80
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK441378
Product name
1-Boc-3-piperidinecarboxaldehyde
Purity
97%
Packaging
250mg
Price
$43
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139948
Product name
tert-Butyl 3-formylpiperidine-1-carboxylate
Packaging
1g
Price
$50
Updated
2021/12/16
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1-BOC-3-PIPERIDINECARBOXALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

1-Boc-piperidine-3-carboxaldehyde is used as an organic chemical synthesis intermediate.

Synthesis

116574-71-1

118156-93-7

General procedure for the synthesis of 1-Boc-3-piperidinecarboxaldehyde from tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate: a solution of dimethylsulfoxide (DMSO, 0.18 mL, 2.6 mmol) in dichloromethane (CH2Cl2, 5 mL) was slowly added dropwise at -78 °C to a solution of oxalyl chloride (2 M in CH2Cl2, 0.65 mL, 1.3 mmol ) in a solution of methylene chloride (4 mL). The reaction mixture was stirred at -68 °C for 15 min. Subsequently, tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate (0.22 g, 1.0 mmol) was added dropwise to a dichloromethane (4 mL) solution. After continued stirring at -78 °C for 15 min, triethylamine (Et3N, 6 mL) was added. The reaction mixture was warmed to room temperature and stirred for 16 hours. Upon completion of the reaction, water was added to quench the reaction and the mixture was extracted with ether. The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the yellow oily product 1-Boc-3-piperidinecarboxaldehyde (0.20 g, 92% yield). The crude product could be directly used in the subsequent reaction without further purification. Mass spectrum (ESI) m/z 214 (M + 1).

References

[1] Patent: WO2006/62465, 2006, A1. Location in patent: Page/Page column 40
[2] Patent: US2004/229864, 2004, A1. Location in patent: Page/Page column 11
[3] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0560-0561
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 4, p. 1368 - 1373
[5] Patent: US2014/31354, 2014, A1. Location in patent: Paragraph 0421; 0422

1-BOC-3-PIPERIDINECARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-3-PIPERIDINECARBOXALDEHYDE Suppliers

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View Lastest Price from 1-BOC-3-PIPERIDINECARBOXALDEHYDE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N-BOC-3-piperidine carboxyaldehyde 118156-93-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08
Wuhan Xinhao Biotechnology Co., Ltd
Product
1-BOC-3-PIPERIDINECARBOXALDEHYDE 118156-93-7
Price
US $10.00-100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Metric Ton/Month
Release date
2024-03-19
Hebei Mingeng Biotechnology Co., Ltd
Product
1-Boc-3-Formylpiperidine 118156-93-7
Price
US $200.00/KG
Min. Order
10g
Purity
99%
Supply Ability
500kg/month
Release date
2021-12-17

118156-93-7, 1-BOC-3-PIPERIDINECARBOXALDEHYDERelated Search:

1-N-Boc-2-piperidinecarboxaldehyde,1-Boc-2-Piperidinecarboxaldehyde 1-BOC-4-PIPERIDINECARBOXALDEHYDE,1-N-Boc-4-piperidinecarboxaldehyde 1-TERT-BUTYL 2-METHYL PIPERIDINE-1,2-DICARBOXYLATE N-BOC-3-Aminopiperidine N-Boc-4-piperidinemethanol (+/-)-1-N-BOC-PIPERIDINE-2-CARBOXAMIDE N-BOC-piperidine-4-carboxylic acid N-Boc-2-piperidinecarboxylic acid Ethyl N-Boc-piperidine-4-carboxylate Ethyl 1-Boc-piperidine-2-carboxylate 1-Boc-3-hydroxypiperidine N-Boc-Piperidine-4-carboxylic acid methyl ester N-Boc-piperidine-3-methanol N-Boc-piperidine-2-methanol TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE 1-Boc-4-Methylaminopiperidine 1-N-BOC-PIPERIDINE-3-CARBOXAMIDE 1-Boc-3-piperidone

  • N-BOC-3-PIPERIDINYLCARBOXALDEHYDE
  • N-BOC-3-FORMYLPIPERIDINE
  • BOC-3-PIPERIDINECARBOXALDEHYDE
  • BUTTPARK 147\06-01
  • 1-BOC-3-PIPERIDINECARBOXALDEHYDE
  • 1-N-BOC-3-FORMYLPIPERIDINE
  • 3-FORMYLPIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 1-Piperidinecarboxylic acid, 3-formyl-, 1,1-dimethylethyl ester
  • Piperidine-3-carboxaldehyde, N-BOC protected
  • N-Boc-3-piperidinecarboxaldehyde
  • 1-Boc-3-formylpiperidine
  • Piperidine-3-carboxaldehyde, N-BOC protected 98%
  • tert-butyl 3-formylpiperidine-1-carboxylate
  • 1-Boc-piperidine-3-carboxaldehyde
  • tert-Butyl 3-formylpiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-formylpiperidine
  • 3-FORMYLPIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ES
  • 3-ForMyl-N-BOCpiperidine
  • 1-Boc-3-ForMyl-piperidine 97%
  • N-BOC-3-piperidine carboxyaldehyde
  • 1-BOC-3-PIPERIDINECA
  • 1-BOC-3-PIPERIDINECAR
  • 3-Formyl-N-(tert-butoxycarbonyl)piperidine
  • N-boc -3- piperidine carboxylaldehyde
  • TIANFUCHEM--118156-93-7-- 1-BOC-3-PIPERIDINECARBOXALDEHYDE factory price
  • CAS:118156-93-7
  • 118156-93-7
  • pharmacetical
  • Piperidine